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Javaheri, A., Noorishadkam, M., Mazaheri, M., Dadbinpour, A., Dastgheib, S., Bahrami, R., Karimi-Zarchi, M., Asadian, F., Neamatzadeh, H. (2020). Current State of Knowledge about Transplacental Transmission of SARS-CoV-2 Infection. Shahid Sadoughi University of Medical Sciences- Journal Management System, 3(2), 50-55. doi: 10.18502/wjpn.v3i2.6154
Atiyeh Javaheri; Mahmood Noorishadkam; Mahta Mazaheri; Ali Dadbinpour; Seyed Alireza Dastgheib; Reza Bahrami; Mojgan Karimi-Zarchi; Fatemeh Asadian; Hossein Neamatzadeh. "Current State of Knowledge about Transplacental Transmission of SARS-CoV-2 Infection". Shahid Sadoughi University of Medical Sciences- Journal Management System, 3, 2, 2020, 50-55. doi: 10.18502/wjpn.v3i2.6154
Javaheri, A., Noorishadkam, M., Mazaheri, M., Dadbinpour, A., Dastgheib, S., Bahrami, R., Karimi-Zarchi, M., Asadian, F., Neamatzadeh, H. (2020). 'Current State of Knowledge about Transplacental Transmission of SARS-CoV-2 Infection', Shahid Sadoughi University of Medical Sciences- Journal Management System, 3(2), pp. 50-55. doi: 10.18502/wjpn.v3i2.6154
Javaheri, A., Noorishadkam, M., Mazaheri, M., Dadbinpour, A., Dastgheib, S., Bahrami, R., Karimi-Zarchi, M., Asadian, F., Neamatzadeh, H. Current State of Knowledge about Transplacental Transmission of SARS-CoV-2 Infection. Shahid Sadoughi University of Medical Sciences- Journal Management System, 2020; 3(2): 50-55. doi: 10.18502/wjpn.v3i2.6154

Current State of Knowledge about Transplacental Transmission of SARS-CoV-2 Infection

World Journal of Peri and Neonatology
Volume 3, Issue 2, December 2020, Pages 50-55    PDF (415.35 K)
Document Type: Scientific Review
DOI: 10.18502/wjpn.v3i2.6154
Authors
Atiyeh Javaheri1; Mahmood Noorishadkam2; Mahta Mazaheri2, 3, 4; Ali Dadbinpour3; Seyed Alireza Dastgheib5; Reza Bahrami* 6; Mojgan Karimi-Zarchi7, 8; Fatemeh Asadian9; Hossein Neamatzadeh2, 3
1Department of Obstetrics and Gynecology, Shahid Sadoughi University of Medical Sciences, Yazd, Iran
2Mother and Newborn Health Research Center, Shahid Sadoughi University of Medical Sciences, Yazd, Iran
3Department of Medical Genetics, School of Medicine, Shahid Sadoughi University of Medical Sciences, Yazd, Iran
4Stem Cell Biology Research Center, Yazd Reproductive Sciences Institute, Shahid Sadoughi University of Medical Sciences, Yazd, Iran
5Department of Medical Genetics, School of Medicine, Shiraz University of Medical Sciences, Shiraz, Iran
6Neonatal Research Center, Shiraz University of Medical Sciences, Shiraz, Iran
7Endometriosis Research Center, Iran University of Medical Sciences, Tehran, Iran
8Department of Obstetrics and Gynecology, Iran University of Medical Sciences, Tehran, Iran
9Department of Medical Laboratory Sciences, School of Paramedical Science, Shiraz University of Medical Sciences, Shiraz, Iran
Abstract
Background: To date, some cases of perinatal transmission of severe acute respiratory syndrome coronavirus-2 (SARS‐CoV‐2) have been reported. However, it is unanswered if these occurred via the trans-placental or the trans-cervical route or through environmental exposure.
Methods: To address this question, we conducted this study to review the current state of knowledge about the transplacental transmission of COVID-19.
Results: There are no known placental findings associated with the COVID-19 infection. The possibility of intrauterine infection has been based mainly on the detection of IgM in the neonatal blood. Real time-PCR tests on amniotic fluid, placenta, and cord blood are required to ascertain the possibility of intrauterine vertical transmission.
Conclusion: There is currently no sufficient and convincing evidence about the transplacental transmission of SARS-COV-2 infection in pregnant mothers. However, the paucity of placental expression of ACE-2 involved in the cytoplasmic entry of SARS-CoV-2 may explain its relative insensitivity to transplacental infection.
Keywords
COVID-19; SARS‐CoV‐2; Placenta; Intrauterine Transmission; Transplacental Transmission; Neonates
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