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Amooee, A., Niktabar, S., Akbarian-Bafghi, M., Morovati-Sharifabad, M., Lookzadeh, M., Mirjalili, S., Khajehnoori, S., Neamatzadeh, H. (2019). Association between Transforming Growth Factor Alpha TaqI Polymorphism and Susceptibility to the Nonsyndromic Cleft Lip and/or Palate in an Iranian Population: A Case Control Study. Shahid Sadoughi University of Medical Sciences- Journal Management System, 2(1), 9-14. doi: 10.18502/wjpn.v2i1.2806
Abdolhamid Amooee; Seyed Mohammadreza Niktabar; Mohammad Javad Akbarian-Bafghi; Majid Morovati-Sharifabad; Mohamad Hosein Lookzadeh; Seyed Reza Mirjalili; Sahel Khajehnoori; Hossein Neamatzadeh. "Association between Transforming Growth Factor Alpha TaqI Polymorphism and Susceptibility to the Nonsyndromic Cleft Lip and/or Palate in an Iranian Population: A Case Control Study". Shahid Sadoughi University of Medical Sciences- Journal Management System, 2, 1, 2019, 9-14. doi: 10.18502/wjpn.v2i1.2806
Amooee, A., Niktabar, S., Akbarian-Bafghi, M., Morovati-Sharifabad, M., Lookzadeh, M., Mirjalili, S., Khajehnoori, S., Neamatzadeh, H. (2019). 'Association between Transforming Growth Factor Alpha TaqI Polymorphism and Susceptibility to the Nonsyndromic Cleft Lip and/or Palate in an Iranian Population: A Case Control Study', Shahid Sadoughi University of Medical Sciences- Journal Management System, 2(1), pp. 9-14. doi: 10.18502/wjpn.v2i1.2806
Amooee, A., Niktabar, S., Akbarian-Bafghi, M., Morovati-Sharifabad, M., Lookzadeh, M., Mirjalili, S., Khajehnoori, S., Neamatzadeh, H. Association between Transforming Growth Factor Alpha TaqI Polymorphism and Susceptibility to the Nonsyndromic Cleft Lip and/or Palate in an Iranian Population: A Case Control Study. Shahid Sadoughi University of Medical Sciences- Journal Management System, 2019; 2(1): 9-14. doi: 10.18502/wjpn.v2i1.2806

Association between Transforming Growth Factor Alpha TaqI Polymorphism and Susceptibility to the Nonsyndromic Cleft Lip and/or Palate in an Iranian Population: A Case Control Study

World Journal of Peri and Neonatology
Volume 2, Issue 1, April 2019, Pages 9-14    PDF (340.25 K)
DOI: 10.18502/wjpn.v2i1.2806
Authors
Abdolhamid Amooee1; Seyed Mohammadreza Niktabar* 1; Mohammad Javad Akbarian-Bafghi2; Majid Morovati-Sharifabad3; Mohamad Hosein Lookzadeh4; Seyed Reza Mirjalili4; Sahel Khajehnoori5, 6; Hossein Neamatzadeh5, 6
1Department of Surgery, Shahid Sadoughi University of Medical Sciences, Yazd, Iran
2Department of Health Care Management, Bam University of Medical Sciences, Bam, Iran
3Department of Basic Science, Faculty of Veterinary Medicine, Ardakan University, Ardakan, Iran
4Department of Pediatrics, Shahid Sadoughi University of Medical Sciences, Yazd, Iran
5Department of Medical Genetics, Shahid Sadoughi University of Medical Sciences, Yazd, Iran
6Mother and Newborn Health Research Center, Shahid Sadoughi University of Medical Sciences, Yazd, Iran
Abstract
Background: The TGF-α TaqI C >T polymorphism is a well-characterized variant for nonsyndromic cleft lip and/or palate (NS CL/P), but it has shown inconsistent results of association with nonsyndromic CL/P across a number of studies. Thus, we have performed this case-control study to clarify the association between the TGF-α TaqI C >T polymorphism and NS CL/P risk.
 
Methods: One-hundred ten cases with NSCL/P and 110 controls were recruited to the current study. We have genotyped the TGF-α TaqI C >T polymorphism using polymerase chain reaction-restriction fragment length polymorphism (PCR-RFLP) method. The odds ratio (OR) and 95% confidence interval (CI) were applied for strength of association TGF-α TaqI C >T polymorphism with NSCL/P.
 
Results: The TGF-α TaqI C >T polymorphism CC, CT and TT genotypes frequencies in the NSCL/P cases were 30.9%, 57.3% and 11.8%, respectively while the corresponding frequencies in the controls were 37.3%, 52.7% and 10.0%, respectively. The frequency of C and T alleles in the case were 59.5% and 40.5%, respectively while the corresponding allelic frequencies in the controls were 63.6% and 36.4%. There was no significant difference in the genotype and allele frequency for TGF-α TaqI C >T polymorphism between cases and controls. The minor allele frequency (MAF) of TGF-α TaqI C >T polymorphism among healthy controls was 0.36.
 
Conclusion: Our study indicates that the TGF-α TaqI C>T polymorphism was not significantly associated with increased risk of NS CL/P in the Iranian population. However, our results still need to be confirmed by further large and well-designed case-control studies.
Keywords
Nonsyndromic Cleft Lip and/or Palate; TGF-α gene; TaqI C >T; Polymorphism
References
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