Statistics

Number of Journals8
Number of Issues52
Number of Articles381
Article View114,178
PDF Download81,042
Dalili, H., Nayeri, F., Mirjalili, S., Hosseini, S., Abdollahi, A., Shariat, M., Hantoushzadeh, S. (2019). The Relationship of Intrauterine Growth Restriction with Placental Pathologic Changes in Newborns. Shahid Sadoughi University of Medical Sciences- Journal Management System, 2(1), 15-20. doi: 10.18502/wjpn.v2i1.2807
Hossein Dalili; Fatemeh Sadat Nayeri; Seyed Reza Mirjalili; Seyyed Nasrollah Hosseini; Alireza Abdollahi; Mamak Shariat; Sedigheh Hantoushzadeh. "The Relationship of Intrauterine Growth Restriction with Placental Pathologic Changes in Newborns". Shahid Sadoughi University of Medical Sciences- Journal Management System, 2, 1, 2019, 15-20. doi: 10.18502/wjpn.v2i1.2807
Dalili, H., Nayeri, F., Mirjalili, S., Hosseini, S., Abdollahi, A., Shariat, M., Hantoushzadeh, S. (2019). 'The Relationship of Intrauterine Growth Restriction with Placental Pathologic Changes in Newborns', Shahid Sadoughi University of Medical Sciences- Journal Management System, 2(1), pp. 15-20. doi: 10.18502/wjpn.v2i1.2807
Dalili, H., Nayeri, F., Mirjalili, S., Hosseini, S., Abdollahi, A., Shariat, M., Hantoushzadeh, S. The Relationship of Intrauterine Growth Restriction with Placental Pathologic Changes in Newborns. Shahid Sadoughi University of Medical Sciences- Journal Management System, 2019; 2(1): 15-20. doi: 10.18502/wjpn.v2i1.2807

The Relationship of Intrauterine Growth Restriction with Placental Pathologic Changes in Newborns

World Journal of Peri and Neonatology
Volume 2, Issue 1, April 2019, Pages 15-20    PDF (393.94 K)
DOI: 10.18502/wjpn.v2i1.2807
Authors
Hossein Dalili1; Fatemeh Sadat Nayeri1; Seyed Reza Mirjalili* 1, 2; Seyyed Nasrollah Hosseini3; Alireza Abdollahi4; Mamak Shariat1; Sedigheh Hantoushzadeh5
1Maternal, Fetal and Neonatal Research Center, Tehran University of Medical Sciences, Tehran, Iran
2Mother and Newborn Health Research Center, Shahid Sadoughi University of Medical Sciences and Health Services, Yazd, Iran
3Faculty of Ministry of Health and Medical Education, Tehran University of Medical Sciences, Tehran, Iran
4Department of Pathology, Tehran University of Medical Sciences, Tehran, Iran
5Department of obstetrics and gynecology, Tehran University of Medical Sciences, Tehran, Iran
Abstract
Introduction: Intrauterine growth restriction is a multifaceted problem and is associated with a significant increase in the level of morbidity and perinatal mortality. According to some studies, failure of the placenta is responsible for the most cases of intrauterine growth restriction. The aim of this study was to evaluate the placental pathologic changes in the intrauterine growth restriction (IUGR) samples and compare them with normal cases.
 
Methods: A study population consisted of 60 intrauterine growth restriction neonates and 60 normalized neonates born at Tehran Imam Khomeini Hospital between June 2016 and July 2017. The placenta was weighed, immediately after delivery, and the umbilical cord was separated, then stored in 10% formalin and sent for pathological examination as soon as possible. Data collection was performed according to the following items: the pathologist's report, the results of the infants' examination, and the data in the neonatal cases.
 
Results: The intrauterine growth restriction group showed a high frequency of placenta infarction (P < 0.001), inflammation of the villous (P < 0.001), villous fibrosis (P = 0.044), villous vascularization disorder (P = 0.001), prevalence of chorioamnionitis (P = 0.027), prevalence of Syncytiotrophoblastic knots (P < 0.001) and placental necrosis (P = 0.048) than normal group. However, the mean weight of the placenta (P < 0.001), the length and width of the macroscopic placenta changes was less (P < 0.001).
 
Conclusion: The results of the current study showed that a major part of the macroscopic and histological changes are detectable in the intrauterine growth restriction samples, which are considerably more common than normal, although they are not pathognomonic, but in the future, more accurate results can be obtained from more extensive studies.
References
1. Battaglia FC, Lubchenco LO. A practical classification of newborn infants by weight and gestational age. J Pediatr 1967; 71(2): 159-63.
2. Mansour E, Eissa AN, Nofal LM, Salam IF. Incidence and factors leading to low birth weight in Egypt. Int J Pediatr. 2002; 17(4): 223-30.
3. Anderson MS, Hay WW. intrauterine growth restriction and the small-for-gestational-age infant. In: Neonatology pathophysiology and management of the newborn. 5th ed. Philadelphia, PA: Lippincott Williams and Wilkins; 1999.
4. Ananth CV, Peltier MR, Chavez MR, Kirby RS, Getahun D, Vintzileos AM. Recurrence of ischemic placental disease. Obstet Gynecol 2007; 110(1): 128-33.
5. Williams RL. Intrauterine growth curves: intra-and international comparisons with different ethnic groups in California. Prev Med 1975; 4(2): 163-72.
6. Lissauer T, Fanaroff AA, Miall L, Fanaroff J. Neonatology at a Glance. Hoboken, NJ: John Wiley & Sons; 2015.
7. Labarrere C, Althabe O, Telenta M. Chronic villitis of unknown aetiology in placentae of idiopathic small for gestational age infants. Placenta 1982; 3(3): 309-17.
8. van der Veen F, Fox H. The human placenta in idiopathic intrauterine growth retardation: a light and electron microscopic study. Placenta 1983; 4(1): 65-77.
9. Teasdale F. Idiopathic intrauterine growth retardation: histomorphometry of the human placenta. Placenta 1984; 5(1): 83-92.
10. Salafia CM, Minior VK, Pezzullo JC, Popek EJ, Rosenkrantz TS, Vintzileos AM. Intrauterine growth restriction in infants of less than thirty-two weeks’ gestation: associated placental pathologic features. Am J Obstet Gynecol 1995; 173(4): 1049-57.
11. Stallmach T, Hebisch G, Meier K, Dudenhausen JW, Vogel M. Rescue by birth: defective placental maturation and late fetal mortality. Obstet Gynecol 2001; 97(4): 505-9.
12. Sato Y, Benirschke K, Marutsuka K, Yano Y, Hatakeyama K, Iwakiri T, et al. Associations of intrauterine growth restriction with placental pathological factors, maternal factors and fetal factors; clinicopathological findings of 257 Japanese cases. Histol Histopathol 2013; 28(1): 127-32.
13. Yu KM. [Relation between placental morphometry and fetal growth]. Zhonghua Fu Chan Ke Za Zhi 1992; 27(4): 217-9, 250.
[In Chinese].
14. Aherne W, Dunnill MS. Quantitative aspects of placental structure. J Pathol Bacteriol 1966; 91(1): 123-39.
15. Thorne J, Downey P, Mooney EE. Placental pathology associated with small for gestational age infants. Ir Med J 2014; 107(8): 249-50.

Statistics
Article View: 223
PDF Download: 148


Journal Management System. Powered by Sinaweb