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Neamatzadeh, H., Zare-Shehneh, M., Mazaheri, M., Daliri, K., Akbarian, E., Sheikhpour, E. (2021). Association of IRF6 rs2235371 Polymorphism with Non-Syndromic Cleft Lip/Palate: A Meta-analysis. Shahid Sadoughi University of Medical Sciences- Journal Management System, 4(1), 14-22. doi: 10.18502/wjpn.v4i1.7541
Hossein Neamatzadeh; Masoud Zare-Shehneh; Mahta Mazaheri; Karim Daliri; Elahe Akbarian; Elnaz Sheikhpour. "Association of IRF6 rs2235371 Polymorphism with Non-Syndromic Cleft Lip/Palate: A Meta-analysis". Shahid Sadoughi University of Medical Sciences- Journal Management System, 4, 1, 2021, 14-22. doi: 10.18502/wjpn.v4i1.7541
Neamatzadeh, H., Zare-Shehneh, M., Mazaheri, M., Daliri, K., Akbarian, E., Sheikhpour, E. (2021). 'Association of IRF6 rs2235371 Polymorphism with Non-Syndromic Cleft Lip/Palate: A Meta-analysis', Shahid Sadoughi University of Medical Sciences- Journal Management System, 4(1), pp. 14-22. doi: 10.18502/wjpn.v4i1.7541
Neamatzadeh, H., Zare-Shehneh, M., Mazaheri, M., Daliri, K., Akbarian, E., Sheikhpour, E. Association of IRF6 rs2235371 Polymorphism with Non-Syndromic Cleft Lip/Palate: A Meta-analysis. Shahid Sadoughi University of Medical Sciences- Journal Management System, 2021; 4(1): 14-22. doi: 10.18502/wjpn.v4i1.7541

Association of IRF6 rs2235371 Polymorphism with Non-Syndromic Cleft Lip/Palate: A Meta-analysis

World Journal of Peri and Neonatology
Volume 4, Issue 1, June 2021, Pages 14-22    PDF (434.85 K)
Document Type: Systematic Review
DOI: 10.18502/wjpn.v4i1.7541
Authors
Hossein Neamatzadeh1, 2; Masoud Zare-Shehneh* 2; Mahta Mazaheri1, 2, 3; Karim Daliri4; Elahe Akbarian5; Elnaz Sheikhpour6
1Mother and Newborn Health Research Center, Shahid Sadoughi University of Medical Sciences, Yazd, Iran
2Department of Medical Genetics, School of Medicine, Shahid Sadoughi University of Medical Sciences, Yazd, Iran
3Stem Cell Biology Research Center, Yazd Reproductive Sciences Institute, Shahid Sadoughi University of Medical Sciences, Yazd, Iran
4Department of Medical Genetics, School of Medicine, Shiraz University of Medical Sciences, Shiraz, Iran
5Children Growth Disorder Research Center, Shahid Sadoughi University of Medical Sciences, Yazd, Iran
6Hematology and Oncology Research Center, Shahid Sadoughi University of Medical Science, Yazd, Iran
Abstract
Background: The previous published data on the association between interferon regulatory factor 6 (IRF6) polymorphisms and non-syndromic Cleft Lip/Palate (NSCL ± P) risk remained inconclusive. The aim of this study was to conduct a meta-analysis to further assess the associations.
Methods: A comprehensivesearch in PubMed, EMBASE, Web of Science, and CNKI for all eligible studies up July 2021.
Results: A total of 23 studies with 6,161 cases and 8,919 controls were selected for this meta-analysis. Overall pooled analysis suggest a significant association between IRF6 rs2235371 polymorphism and CL±P risk under all the five genetic models, i.e., allele (A vs. G: OR=0.754, 95% CI 0.628-0.905, P=0.002), homozygote (AA vs. GG: OR=0.621 95% 0.405-0.953, P=0.029), heterozygote (AC vs. GG: OR=0.619, 95% CI 0.485-0.791, P≤0.001), dominant (AA+AG vs. GG: OR=0.550, 95% CI 0.381-0.794, P=0.001) and recessive model (AA vs. AG+GG: OR=0.583, 95% CI 0.423-0.804, P=0.001). Subgroup analysis by ethnicity showed that rs2235371 was associated with NSCL±P risk in Asians.
Conclusion: This meta-analysis provides strong evidences that IRF6 rs2235371 might be associated with risk of NSCL ± P.
Keywords
Cleft Lip and Palate; Craniofacial; IRF6 gene; polymorphism; meta-analysis
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