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Javaheri, A., Khajehnoori, S., Foroughi, E., Nasiri, R., Farahnak, S., Tabatabaei, R., Neamatzadeh, H. (2018). Association of MTHFR A1298C Polymorphism with Preterm Birth: A Meta-Analysis. Shahid Sadoughi University of Medical Sciences- Journal Management System, 1(1), 1-6. doi: 10.18502/wjpn.v1i1.2779
Atiyeh Javaheri; Sahel Khajehnoori; Elnaz Foroughi; Rezvan Nasiri; Soudabeh Farahnak; Razieh Sadat Tabatabaei; Hossein Neamatzadeh. "Association of MTHFR A1298C Polymorphism with Preterm Birth: A Meta-Analysis". Shahid Sadoughi University of Medical Sciences- Journal Management System, 1, 1, 2018, 1-6. doi: 10.18502/wjpn.v1i1.2779
Javaheri, A., Khajehnoori, S., Foroughi, E., Nasiri, R., Farahnak, S., Tabatabaei, R., Neamatzadeh, H. (2018). 'Association of MTHFR A1298C Polymorphism with Preterm Birth: A Meta-Analysis', Shahid Sadoughi University of Medical Sciences- Journal Management System, 1(1), pp. 1-6. doi: 10.18502/wjpn.v1i1.2779
Javaheri, A., Khajehnoori, S., Foroughi, E., Nasiri, R., Farahnak, S., Tabatabaei, R., Neamatzadeh, H. Association of MTHFR A1298C Polymorphism with Preterm Birth: A Meta-Analysis. Shahid Sadoughi University of Medical Sciences- Journal Management System, 2018; 1(1): 1-6. doi: 10.18502/wjpn.v1i1.2779

Association of MTHFR A1298C Polymorphism with Preterm Birth: A Meta-Analysis

Journal of Integrated Maternal and Pediatric Care
Volume 1, Issue 1, July 2018, Pages 1-6    PDF (374.35 K)
DOI: 10.18502/wjpn.v1i1.2779
Authors
Atiyeh Javaheri1; Sahel Khajehnoori* 2, 3; Elnaz Foroughi4; Rezvan Nasiri5; Soudabeh Farahnak6; Razieh Sadat Tabatabaei1; Hossein Neamatzadeh2, 3
1Department of Gynecology and Obstetrics, Shahid Sadoughi University of Medical Sciences, Yazd, Iran
2Department of Medical Genetics, Shahid Sadoughi University of Medical Sciences, Yazd, Iran
3Mother and Newborn Health Research Center, Shahid Sadoughi University of Medical Sciences, Yazd, Iran
4Pediatric Dentistry, Arak University of Medical Sciences, Arak, Iran
5Departments of Restorative and Esthetic, Arak University of Medical Sciences, Arak, Iran
6Department of Endodontic, Arak University of Medical Sciences, Arak, Iran
Abstract
Background: A few studies have been conducted to explore the association of MTHFR A1298C (rs1801131) polymorphism with preterm birth risk, the results remain inconsistent. Therefore, we conducted a meta-analysis to derive a more systematic estimation of the association.
 
Method: Relevant studies were searched by PubMed, EMBASE, CNKI, and Google Scholar up to June 2018. The strength of the association of MTHFR A1298C polymorphism with preterm birth was calculated by odds ratios (OR) with 95% confidence interval (95%CI).
 
Results: A total of nine case-control studies with 1,609 cases and 14,981 controls were included. Pooled results showed that there was no significant association between MTHFR A1298C polymorphism and preterm birth risk under all five genetic models in overall. However, in the stratified analysis of ethnicity, a significant association between MTHFR A1298C polymorphism and preterm birth risk was observed in the Asians under four genetic models, i.e., allele (C vs. A: OR = 0.960, 95% CI 0.543-0.871, P = 0.002), heterozygote (CA vs. AA: OR = 0.887, 95% CI 0.024-0.457, P = 0.003), dominant (CC+CA vs. AA: OR = 0.965, 95% CI 0.534 -0.935, P = 0.015) and recessive (CC vs. CA+AA: OR = 0.923, 95% CI 0.026-0491, P = 0.004), but not in Caucasians.
 
Conclusion: This meta-analysis suggested that MTHFR A1298C polymorphism is not associated with preterm birth risk in overall population. However, MTHFR A1298C polymorphism plays an important role in preterm birth development in Asian population.
Keywords
Preterm Birth; MTHFR Gene; Polymorphism; Meta-analysis
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