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Bahrami, R., Ekraminasab, S., Asadian, F. (2021). A Survey on Cardiac Complications of COVID-19 in Infants. Shahid Sadoughi University of Medical Sciences- Journal Management System, 4(1), 50-59. doi: 10.18502/wjpn.v4i1.7544
Reza Bahrami; Sedigheh Ekraminasab; Fatemeh Asadian. "A Survey on Cardiac Complications of COVID-19 in Infants". Shahid Sadoughi University of Medical Sciences- Journal Management System, 4, 1, 2021, 50-59. doi: 10.18502/wjpn.v4i1.7544
Bahrami, R., Ekraminasab, S., Asadian, F. (2021). 'A Survey on Cardiac Complications of COVID-19 in Infants', Shahid Sadoughi University of Medical Sciences- Journal Management System, 4(1), pp. 50-59. doi: 10.18502/wjpn.v4i1.7544
Bahrami, R., Ekraminasab, S., Asadian, F. A Survey on Cardiac Complications of COVID-19 in Infants. Shahid Sadoughi University of Medical Sciences- Journal Management System, 2021; 4(1): 50-59. doi: 10.18502/wjpn.v4i1.7544

A Survey on Cardiac Complications of COVID-19 in Infants

World Journal of Peri and Neonatology
Volume 4, Issue 1, June 2021, Pages 50-59    PDF (475.31 K)
Document Type: Scientific Review
DOI: 10.18502/wjpn.v4i1.7544
Authors
Reza Bahrami1; Sedigheh Ekraminasab* 2, 3; Fatemeh Asadian4
1Neonatal Research Center, Shiraz University of Medical Sciences, Shiraz, Iran
2Mother and Newborn Health Research Center, Shahid Sadoughi University of Medical Sciences, Yazd, Iran
3Department of Hematology and Blood Banking, School of Allied Medical Sciences, Shahid Beheshti University of Medical Sciences, Tehran, Iran
4Department of Medical Laboratory Sciences, School of Paramedical Science, Shiraz University of Medical Sciences, Shiraz, Iran
Abstract
Congenital heart disease (CHD) may have serious effects on the course of COVID-19. Limited data were available on CHD in neonates with COVID-19. This study aimed to review the cardiac complications in neonates infected with COVID-19. Some studies showed that myocardial injury in adult patients is often correlated with a fatal outcome. But, scientific evidence in infants is rare, although several reports were published with the description of cardiac involvement in COVID-19 pediatric patients. In these young subjects, a background of surgically treated CHD seems to be a predisposing factor. Numerous studies showed Multisystem inflammatory syndrome in children (MIS-c) is a deadly demonstration of COVID-19 with cardiac involvement. The underlying pathophysiology of COVID-19-associated cardiovascular complications is not fully understood, although direct viral infection of the myocardium, systemic inflammatory response, coagulation abnormalities and thrombosis and hypoxia have been suggested as possible mechanisms of cardiac complications. It seems COVID-19 can affect different parts of the heart; however, the myocardium is more involved. The mechanisms of pathogenesis of cardiovascular implications in adults and infants are similar but CHD and MIS-c in infants are more important. Further studies on the effects of COVID-19 on the neonatal cardiovascular system are needed.
Keywords
COVID-19; Cardiac; Complications; Heart Disease; Infant
References
  1. Javaheri A, Noorishadkam M, Mazaheri M, Dadbinpour A, Dastgheib SA, Bahrami R, et al. Current State of Knowledge about Transplacental Transmission of SARS-CoV-2 Infection. World J Peri Neonatol 2021; 3(2): 50-5.
  2. Zhu N, Zhang D, Wang W, Li X, Yang B, Song J, et al. A Novel Coronavirus from patients with pneumonia in China, 2019. N Engl J Med 2020; 382(8): 727-33.
  3. Noorishadkam M, Lookzadeh M, Mazaheri M, Mirjalili SR, Bahrami R, Asadian F, et al. Coronavirus Disease 2019 (COVID-19) and late pregnancy loss in infected pregnant women: A mini review. World J Peri Neonatol 2020; 2(2): 67-70.
  4. Clerkin KJ, Fried JA, Raikhelkar J, Sayer G, Griffin JM, Masoumi A, et al. COVID-19 and cardiovascular disease. Circulation 2020; 141(20): 1648-55.
  5. Bahrami R, Neamatzadeh H, Akbarian E. COVID-19 and renal complications in neonates and pediatrics. World J Peri Neonatol 2021; 3(2): 48-9.
  6. Dong Y, Mo X, Hu Y, Qi X, Jiang F, Jiang Z, et al. Epidemiology of COVID-19 among children in China. Pediatrics 2020; 145(6): e20200702.
  7. Tan W, Aboulhosn J. The cardiovascular burden of coronavirus disease 2019 (COVID-19) with a focus on congenital heart disease. Int J Cardiol 2020; 309: 70-7.
  8. Zimmermann P, Curtis N. Coronavirus infections in children including COVID-19: An overview of the epidemiology, clinical features, diagnosis, treatment and prevention options in children. Pediatr Infect Dis J 2020; 39(5): 355-68.
  9. Sanna G, Serrau G, Bassareo PP, Neroni P, Fanos V, Marcialis MA. Children’s heart and COVID-19: Up-to-date evidence in the form of a systematic review. Eur J Pediatr 2020; 179(7): 1079-87.
  10. Siebach MK, Piedimonte G, Ley SH. COVID-19 in childhood: Transmission, clinical presentation, complications and risk factors. Pediatr Pulmonol 2021; 56(6): 1342-56.
  11. Elbehery M, Munshi FA, Alzahrani A, Bakhsh M, Alariefy M. COVID-19 in an intrauterine growth restriction (IUGR) infant with congenital heart disease: Case report and literature review. Cureus 2020; 12(9): e10294.
  12. Farshidfar F, Koleini N, Ardehali H. Cardiovascular complications of COVID-19 Cardiovascular complications of COVID-19. JCI Insight 2021; 6(13): e148980.
  13. Caforio ALP, Pankuweit S, Arbustini E, Basso C, Gimeno-Blanes J, Felix SB, et al. Current state of knowledge on aetiology, diagnosis, management, and therapy of myocarditis: A position statement of the European Society of Cardiology Working Group on Myocardial and Pericardial Diseases. Eur Heart J 2013; 34(33): 2636-48.
  14. Lee CCE, Ali K, Connell D, Mordi IR, George J, Lang EMSL. COVID-19-Associated cardiovascular complications. Diseases 2021; 9(3): 47.
  15. Guo T, Fan Y, Chen M, Wu X, Zhang L, He T, et al. Cardiovascular implications of fatal outcomes of patients with coronavirus disease 2019 (COVID-19). JAMA Cardiol 2020; 5(7): 811-8.
  16. Zhou F, Yu T, Du R, Fan G, Liu Y, Liu Z, et al. Clinical course and risk factors for mortality of adult inpatients with COVID-19 in Wuhan, China: a retrospective cohort study. Lancet 2020; 395(10229): 1054-62.
  17. Chang WT, Siong Toh H, Liao CT, Yu WL. Cardiac involvement of COVID-19: A comprehensive review. Am J Med Sci 2021; 361(1): 14-22.
  18. Liu K, Fang YY, Deng Y, Liu W, Wang MF, Ma JP, et al. Clinical characteristics of novel coronavirus cases in tertiary hospitals in Hubei Province. Chin Med J (Engl) 2020; 133(9): 1025-31.
  19. Turagam MK, Musikantow D, Goldman ME, Bassily-Marcus A, Chu E, Shivamurthy P, et al. Malignant arrhythmias in patients with COVID-19: Incidence, mechanisms, and outcomes. Circ Arrhythm Electrophysiol 2020; 13(11): e008920.
  20. Nishiga M, Wang DW, Han Y, Lewis DB, Wu JC. COVID-19 and cardiovascular disease: from basic mechanisms to clinical perspectives. Nat Rev Cardiol 2020; 17(9): 543-58.
  21. Garazzino S, Montagnani C, Donà D, Meini A, Felici E, Vergine G, et al. Multicentre Italian study of SARS-CoV-2 infection in children and adolescents, preliminary data as at 10 April 2020. Euro Surveill 2020; 25(18): 1-4.
  22. Zachariah P, Johnson CL, Halabi KC, Ahn D, Sen AI, Fischer A, et al. Epidemiology, clinical features, and disease severity in patients with coronavirus disease 2019 (COVID-19) in a children’s hospital in New York City, New York. JAMA Pediatr 2020; 174(10): e202430.
  23. Grimaud M, Starck J, Levy M, Marais C, Chareyre J, Khraiche D, et al. Acute myocarditis and multisystem inflammatory emerging disease following SARS-CoV-2 infection in critically ill children. Ann Intensive Care 2020; 10(1): 69.
  24. Riollano-Cruz M, Akkoyun E, Briceno-Brito E, Kowalsky S, Reed J, Posada R, et al. Multisystem inflammatory syndrome in children related to COVID-19: A New York City experience. J Med Virol 2021; 93(1): 424-33.
  25. McCrindle BW, Rowley AH, Newburger JW, Burns JC, Bolger AF, Gewitz M, et al. Diagnosis, treatment, and long-term management of Kawasaki disease: A scientific statement for health professionals from the American Heart Association. Circulation 2017; 135(17): e927-99.
  26. Rodriguez-Gonzalez M, Castellano-Martinez A, Cascales-Poyatos HM, Perez-Reviriego AA. Cardiovascular impact of COVID-19 with a focus on children: A systematic review. World J Clin Cases 2020; 8(21): 5250-283.
  27. Soleimani A, Soleimani Z. Presentation and outcome of congenital heart disease during Covid-19 pandemic: A review. Curr Probl Cardiol 2021; 100905
  28. Smith SW, Strobel AM, Saenger AK, Apple FS. Laboratory fi ndings in a child with SARS-CoV-2 (COVID-19) multisystem in fl ammatory syndrome. Clin Chem Lab Med 2021; 59(6): e259-61.
  29. Wu W, He J, Shao X. Incidence and mortality trend of congenital heart disease at the global, regional, and national level, 1990-2017. Medicine (Baltimore) 2020; 99(23): e20593.
  30. Bouma BJ, Mulder BJM. Changing landscape of congenital heart disease. Circ Res 2017; 120(6): 908-22.
  31. Haji Esmaeil Memar E, Pourakbari B, Gorgi M, Sharifzadeh Ekbatani M, Navaeian A, Khodabandeh M, et al. COVID-19 and congenital heart disease: a case series of nine children. World J Pediatr 2021; 17(1): 71-8.
  32. Zheng YY, Ma YT, Zhang JY, Xie X. COVID-19 and the cardiovascular system. Nat Rev Cardiol 2020; 17(5): 259-60.
  33. Xu Z, Shi L, Wang Y, Zhang J, Huang L, Zhang C, et al. Pathological findings of COVID-19 associated with acute respiratory distress syndrome. Lancet Respir Med 2020; 8(4): 420-2.
  34. Salamanna F, Maglio M, Landini MP, Fini M. Body Localization of ACE-2: On the Trail of the Keyhole of SARS-CoV-2. Front Med 2020; 7(12): 1-24.
  35. Xiong TY, Redwood S, Prendergast B, Chen M. Coronaviruses and the cardiovascular system: Acute and long-term implications. Eur Heart J 2020; 41(19): 179-800.
  36. Basu-Ray B, Almaddah NK, Adeboye A, Soos MP. Cardiac manifestations of coronavirus (COVID-19). StatPearls 2021; (5)19.
  37. Young BE, Ong SWX, Kalimuddin S, Low JG, Tan SY, Loh J, et al. Epidemiologic features and clinical course of patients infected with SARS-CoV-2 in Singapore. JAMA 2020; 323(15): 1488-94.
  38. Hu H, Ma F, Wei X, Fang Y. Coronavirus fulminant myocarditis treated with glucocorticoid and human immunoglobulin. Eur Heart J 2021; 42(2): 206.
  39. Tay MZ, Poh CM, Rénia L, MacAry PA, Ng LFP. The trinity of COVID-19: immunity, inflammation and intervention. Nat Rev Immunol 2020; 20(6): 363-74.
  40. Fu Y, Cheng Y, Wu Y. Understanding SARS-CoV-2-Mediated inflammatory responses: From mechanisms to potential therapeutic tools. Virol Sin 2020; 35(3): 266-71.
  41. Russell CD, Millar JE, Baillie JK. Clinical evidence does not support corticosteroid treatment for 2019-nCoV lung injury. Lancet 2020; 395(10223): 473-5.
  42. Liu B, Li M, Zhou Z, Guan X, Xiang Y. Can we use interleukin-6 (IL-6) blockade for coronavirus disease 2019 (COVID-19)-induced cytokine release syndrome (CRS)? J Autoimmun 2020; 111: 102452.
  43. Abou-ismail MY, Diamond A, Kapoor S, Arafah Y, Nayak L. The hypercoagulable state in COVID-19: Incidence, pathophysiology, and management. Thromb Res 2020; 194: 101-15.
  44. Dehghan H, Soleimani A. Pulmonary thromboembolism with multiple right heart mural thrombus in a patient with COVID-19. J Echocardiogr 2020; (0123456789): 1-2.
  45. Mansueto G, Niola M, Napoli C. Can COVID 2019 induce a specific cardiovascular damage or it exacerbates pre-existing cardiovascular diseases? Pathol Res Pract 2020; 216(9): 153086.
  46. De Rosa S, Spaccarotella C, Basso C, Calabrò MP, Curcio A, Filardi PP, et al. Reduction of hospitalizations for myocardial infarction in Italy in the COVID-19 era. Eur Heart J 2020; 41(22): 2083-8.
  47. Wang T, Chen R, Liu C, Liang W, Guan W, Tang R, et al. Attention should be paid to venous thromboembolism prophylaxis in the management of COVID-19. Lancet Haematol 2020; 7(5): e362-3.
  48. Loo J, Spittle DA, Newnham M. COVID-19, immunothrombosis and venous thromboembolism: Biological mechanisms. Thorax 2021; 76(4): 412-20.
  49. Wang J, Hajizadeh N, Moore EE, McIntyre RC, Moore PK, Veress LA, et al. Tissue plasminogen activator (tPA) treatment for COVID-19 associated acute respiratory distress syndrome (ARDS): A case series. J Thromb Haemost 2020; 18(7): 1752-5.
  50. Mirjalili H, Dastgheib SA, Shaker SH, Bahrami R, Mazaheri M, Sadr-Bafghi SMH, et al. Proportion and mortality of Iranian diabetes mellitus, chronic kidney disease, hypertension and cardiovascular disease patients with COVID-19: a meta-analysis. J Diabetes Metab Disord 2021; 20(1): 1-13.
  51. Topjian A, Aziz K, Kamath-Rayne BD, Atkins DL, Becker L, Berg RA, et al. Interim guidance for basic and advanced life support in children and neonates with suspected or confirmed COVID-19. Pediatrics 2020; e20201405.
  52. Belhadjer Z, Méot M, Bajolle F, Khraiche D, Legendre A, Abakka S, et al. Acute heart failure in multisystem inflammatory syndrome in children in the context of global SARS-CoV-2 pandemic. Circulation 2020; 142(5): 429-36.
  53. Ranucci M, Ballotta A, Di Dedda U, Bayshnikova E, Dei Poli M, Resta M, et al. The procoagulant pattern of patients with COVID-19 acute respiratory distress syndrome. J Thromb Haemost 2020; 18(7): 1747-51.
  54. Shi S, Qin M, Shen B, Cai Y, Liu T, Yang F, et al. Association of cardiac injury with mortality in hospitalized patients with COVID-19 in Wuhan, China. JAMA Cardiol 2020; 5(7): 802-10. 
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