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Hajialiakbari, N., Schwartz, D., Javaheri, A., Karimi-Zarchi, M., Golshan-Tafti, M., Dastgheib, S., Bahrami, R., Zanbagh, L., Neamatzadeh, H. (2021). A Meta-Analysis for Frequency of Miscarriage in Pregnant Women with COVID-19. Shahid Sadoughi University of Medical Sciences- Journal Management System, 4(2), 104-114. doi: 10.18502/wjpn.v4i2.8648
Negin Hajialiakbari; David A. Schwartz; Atiyeh Javaheri; Mojgan Karimi-Zarchi; Mohammad Golshan-Tafti; Seyed Alireza Dastgheib; Reza Bahrami; Leila Zanbagh; Hossein Neamatzadeh. "A Meta-Analysis for Frequency of Miscarriage in Pregnant Women with COVID-19". Shahid Sadoughi University of Medical Sciences- Journal Management System, 4, 2, 2021, 104-114. doi: 10.18502/wjpn.v4i2.8648
Hajialiakbari, N., Schwartz, D., Javaheri, A., Karimi-Zarchi, M., Golshan-Tafti, M., Dastgheib, S., Bahrami, R., Zanbagh, L., Neamatzadeh, H. (2021). 'A Meta-Analysis for Frequency of Miscarriage in Pregnant Women with COVID-19', Shahid Sadoughi University of Medical Sciences- Journal Management System, 4(2), pp. 104-114. doi: 10.18502/wjpn.v4i2.8648
Hajialiakbari, N., Schwartz, D., Javaheri, A., Karimi-Zarchi, M., Golshan-Tafti, M., Dastgheib, S., Bahrami, R., Zanbagh, L., Neamatzadeh, H. A Meta-Analysis for Frequency of Miscarriage in Pregnant Women with COVID-19. Shahid Sadoughi University of Medical Sciences- Journal Management System, 2021; 4(2): 104-114. doi: 10.18502/wjpn.v4i2.8648

A Meta-Analysis for Frequency of Miscarriage in Pregnant Women with COVID-19

World Journal of Peri and Neonatology
Volume 4, Issue 2, December 2021, Pages 104-114    PDF (910.71 K)
Document Type: Systematic Review
DOI: 10.18502/wjpn.v4i2.8648
Authors
Negin Hajialiakbari1; David A. Schwartz2; Atiyeh Javaheri3; Mojgan Karimi-Zarchi4, 5; Mohammad Golshan-Tafti6; Seyed Alireza Dastgheib7; Reza Bahrami* 8; Leila Zanbagh9; Hossein Neamatzadeh10, 11
1Department of Obstetrics and Gynecology, Kermanshah University of Medical Sciences, Kermanshah, Iran
2Department of Pathology, Medical College of Georgia, Augusta, GA, USA
3Department of Obstetrics and Gynecology, Shahid Sadoughi University of Medical Sciences, Yazd, Iran
4Endometriosis Research Center, Iran University of Medical Sciences, Firoozgar Hospital, Tehran, Iran
5Department of Obstetrics and Gynecology, Iran University of Medical Sciences, Tehran, Iran
6Department of Pediatrics, Islamic Azad University of Yazd, Yazd, Iran
7Department of Medical Genetics, School of Medicine, Shiraz University of Medical Sciences, Shiraz, Iran
8Neonatal Research Center, Shiraz University of Medical Sciences, Shiraz, Iran
9Department of Obstetrics and Gynecology, Yazd Branch, Islamic Azad University, Yazd, Iran
10Mother and Newborn Health Research Center, Shahid Sadoughi University of Medical Sciences, Yazd, Iran
11Department of Medical Genetics, School of Medicine, Shahid Sadoughi University of Medical Sciences, Yazd, Iran
Abstract
Background: Most pregnant women with COVID-19 develop less severe form of the disease, with few cases of severe maternal morbidity and mortality, or perinatal deaths. This meta-analysis was conducted to evaluate the frequency of miscarriage in pregnant women affected by the SARS-COV-2 infection.
Methods: A comprehensive search was performed in online databases to identify all relevant studies published up to 5th March 2021. Case-control studies and case series reported the frequency of miscarriage in pregnant women with COVID-19 was selected.
Results: A total of 22 studies with 8591 infected pregnant women and 141 abortions were selected. The frequency of miscarriage was 3.9% (95% CI 0.023-0.063) in infected pregnant women with COVID-19. It had the highest frequency in Asian (6.3%) followed by European (2.9%), West-Asian (2.5%) and Caucasian (2.3%) infected pregnant women. Moreover, stratified analysis by country showed that the frequency of miscarriage is the highest in Chinese (11.3%) followed by Italy (11.2%), India (2.7%), Turkey (2.2%), USA (1.2%) and France (0.9%) infected pregnant women.
Conclusion: Our pooled data revealed that the frequencies of miscarriage in pregnant women with SARS-COV-2 infection were 3.9%.
Keywords
SARS-COV-2; COVID-19; Pregnancy; Abortion; Miscarriage; Frequency
References
  1. Komine-Aizawa S, Takada K, Hayakawa S. Placental barrier against COVID-19. Placenta 2020; 99: 45-9.
  2. Karimi-Zarchi M, Neamatzadeh H, Dastgheib SA, Abbasi H, Mirjalili SR, Behforouz A, et al. Vertical transmission of coronavirus disease 19 (COVID-19) from infected pregnant mothers to neonates: a review. Fetal Pediatr Pathol 2020; 39(3): 246-50.
  3. Alkatout I, Karimi-Zarchi M, Allahqoli L. Gynecological cancers and the global COVID-19 pandemic. J Turk Ger Gynecol Assoc 2020; 21(4): 272-8.
  4. Mullins E, Evans D, Viner R, O’Brien P, Morris E. Coronavirus in pregnancy and delivery: Rapid review and expert consensus. Ultrasound Obstet Gynecol 2020; 55(5): 586-92.
  5. Panahi L, Amiri M, Pouy S. Risks of novel coronavirus disease (COVID-19) in pregnancy; a narrative review. Arch Acad Emerg Med 2020; 8(1): e34.
  6. Lee RWK, Loy SL, Yang L, Chan JKY, Tan LK. Attitudes and precaution practices towards COVID-19 among pregnant women in Singapore: a cross-sectional survey. BMC Pregnancy Childbirth 2020; 20(1): 675.
  7. Diriba K, Awulachew E, Getu E. The effect of coronavirus infection (SARS-CoV-2, MERS-CoV, and SARS-COV) during pregnancy and the possibility of vertical maternal-fetal transmission: a systematic review and meta-analysis. Eur J Med Res 2020; 25(1): 39.
  8. Wong TC, Lee ZY, Sia TLL, Chang AKW, Chua HH. Miscarriage risk in COVID-19 infection. SN Compr Clin Med 2020; 2(9): 1449-52.
  9. Bahrami R, Dastgheib SA, Niktabar SM, Amooee A, Lookzadeh MH, Mirjalili SR, et al. Association of BMP4 rs17563 polymorphism with nonsyndromic cleft lip with or without cleft palate risk: Literature review and comprehensive meta-analysis. Fetal Pediatr Pathol 2021; 40(4): 305-19.
  10. Shmakov RG, Prikhodko A, Polushkina E, Shmakova E, Pyregov A, Bychenko V, et al. Clinical course of novel COVID-19 infection in pregnant women. J Matern Fetal Neonatal Med 2020: 1-7.
  11. Sahin D, Tanacan A, Erol SA, Anuk AT, Yetiskin FDY, Keskin HL, et al. Updated experience of a tertiary pandemic center on 533 pregnant women with COVID‐19 infection: A prospective cohort study from Turkey. Int J Gynaecol Obstet 2021; 152(3): 328-34.
  12. Sentilhes L, de Marcillac F, Jouffrieau C, Kuhn P, Thuet V, Hansmann Y, et al. Coronavirus disease 2019 in pregnancy was associated with maternal morbidity and preterm birth. Am J Obstet Gynecol 2020; 223(6): 914.e1-914.e15.
  13. Woodworth KR, Olsen EO, Neelam V, Lewis EL, Galang RR, Oduyebo T, et al. Birth and infant outcomes following laboratory-confirmed SARS-COV-2 infection in pregnancy - SET-NET, 16 jurisdictions, March 29-October 14, 2020. MMWR Morb Mortal Wkly Rep 2020; 69(44): 1635-40.
  14. Buonsenso D, Costa S, Sanguinetti M, Cattani P, Posteraro B, Marchetti S, et al. Neonatal late onset infection with severe acute respiratory syndrome coronavirus 2. Am J Perinatol 2020; 37(8): 869-72.
  15. Knight M, Bunch K, Vousden N, Morris E, Simpson N, Gale C, et al. Characteristics and outcomes of pregnant women hospitalised with confirmed SARS-COV-2 infection in the UK: a national cohort study using the UK Obstetric Surveillance System (UKOSS). BMJ 2020; 369:m2107.
  16. Cosma S, Carosso AR, Cusato J, Borella F, Carosso M, Bovetti M, et al. Coronavirus disease 2019 and first-trimester spontaneous abortion: a case-control study of 225 pregnant patients. Am J Obstet Gynecol 2021; 224(4): 391.e1-391.e7.
  17. Delahoy MJ, Whitaker M, O’Halloran A, Chai SJ, Kirley PD, Alden N, et al. Characteristics and Maternal and Birth Outcomes of Hospitalized Pregnant Women with Laboratory-Confirmed COVID-19 - COVID-NET, 13 States, March 1-August 22, 2020. MMWR Morb Mortal Wkly Rep 2020; 69(38): 1347-54.
  18. WAPM (World Association of Perinatal Medicine) Working Group on COVID-19. Maternal and perinatal outcomes of pregnant women with SARS‐COV‐2 infection. Ultrasound Obstet Gynecol 2021; 57(2): 232-41.
  19. Wu X, Sun R, Chen J, Xie Y, Zhang S, Wang X. Radiological findings and clinical characteristics of pregnant women with COVID‐19 pneumonia. Int J Gynaecol Obstet 2020; 150(1): 58-63.
  20. Yan J, Guo J, Fan C, Juan J, Yu X, Li J, et al. Coronavirus disease 2019 in pregnant women: a report based on 116 cases. Am J Obstet Gynecol 2020; 223(1): 111.e1-111.e14.
  21. Ayed A, Embaireeg A, Benawadh A, Al-Fouzan W, Hammoud M, Al-Hathal M, et al. Maternal and perinatal characteristics and outcomes of pregnancies complicated with COVID-19 in Kuwait. BMC Pregnancy Childbirth 2020; 20(1): 754.
  22. Pirjani R, Hosseini R, Soori T, Rabiei M, Hosseini L, Abiri A, et al. Maternal and neonatal outcomes in COVID-19 infected pregnancies: a prospective cohort study. J Travel Med 2020; 27(7): taaa158.
  23. Qiancheng X, Jian S, Lingling P, Lei H, Xiaogan J, Weihua L, et al. Coronavirus disease 2019 in pregnancy. Int J Infect Dis 2020; 95: 376-83.
  24. Chen L, Li Q, Zheng D, Jiang H, Wei Y, Zou L, et al. Clinical characteristics of pregnant women with Covid-19 in Wuhan, China. N Engl J Med 2020; 382(25): e100.
  25. Lei G, Tian J, Peng S, Hu X, Zhang P, Wu W, et al. Clinical observation of different treatment strategies in pregnant women with COVID-19: a retrospective study. [Online]. Cited 2020 June 4. Avilable from: URL: https://www.researchgate.net/publication/341916963_Clinical_observation_of_different_treatment_strategies_in_pregnant_women_with_COVID-19_a_retrospective_study/fulltext/5ed99697458515294536f2ad/Clinical-observation-of-different-treatment-strategies-in-pregnant-women-with-COVID-19-a-retrospective-study.pdf 
  1. Wong SF, Chow KM, Leung TN, Ng WF, Ng TK, Shek CC, et al. Pregnancy and perinatal outcomes of women with severe acute respiratory syndrome. Am J Obstet Gynecol 2004; 191(1): 292-7.
  2. Chen S, Huang B, Luo DJ, Li X, Yang F, Zhao Y, et al. Pregnant women with new coronavirus infection: a clinical characteristics and placental pathological analysis of three cases. Zhonghua Bing Li Xue Za Zhi 2020; 49(5): 418-23. [In Chinese].
  3. Erol SA, Tanacan A, Anuk AT, Tokalioglu EO, Biriken D, Keskin HL, et al. Evaluation of maternal serum afamin and vitamin E levels in pregnant women with COVID‐19 and its association with composite adverse perinatal
    J Med Virol 2021; 93(4): 2350-8.
  4. Tsatsaris V, Mariaggi AA, Launay O, Couffignal C, Rousseau J, Ancel PY, et al. SARS-COV-2 IgG antibody response in pregnant women at delivery. J Gynecol Obstet Hum Reprod 2021; 50(7): 102041.
  5. Kayem G, Lecarpentier E, Deruelle P, Bretelle F, Azria E, Blanc J, et al. A snapshot of the Covid-19 pandemic among pregnant women in France. J Gynecol Obstet Hum Reprod 2020; 49(7): 101826.
  6. Nayak AH, Kapote DS, Fonseca M, Chavan N, Mayekar R, Sarmalkar M, et al. Impact of the coronavirus infection in pregnancy: a preliminary study of 141 patients. J Obstet Gynaecol India 2020; 70(4): 256-61.
  7. Mahajan NN, Ansari M, Gaikwad C, Jadhav P, Tirkey D, Pophalkar MP, et al. Impact of SARS-CoV-2 on multiple gestation pregnancy. Int J Gynaecol Obstet 2021; 152(2): 220-5.
  8. Linnakaari R, Helle N, Mentula M, Bloigu A, Gissler M, Heikinheimo O, et al. Trends in the incidence, rate and treatment of miscarriage - Nationwide register-study in Finland, 1998-2016. Hum Reprod 2019; 34(11): 2120-8.
  9. Seyedhassani SM, Houshmand M, Kalantar SM, Aflatoonian A, Modabber G, Hashemi-Gorji F, et al. BAX pro-apoptotic gene alterations in repeated pregnancy loss. Arch Med Sci 2011; 7(1): 117-22.
  10. Patki A, Chauhan N. An epidemiology study to determine the prevalence and risk factors associated with recurrent spontaneous miscarriage in India. J Obstet Gynaecol India 2016; 66(5): 310-5.
  11. Harb HM, Al-rshoud F, Dhillon R, Harb M, Coomarasamy A. Ethnicity and miscarriage: a large prospective observational study and meta-analysis. Fertility and Sterility 2014; 102(3): e81.
  12. Hachem R, Markou GA, Veluppillai C, Poncelet C. Late miscarriage as a presenting manifestation of COVID-19. Eur J Obstet Gynecol Reprod Biol 2020; 252: 614.
  13. Omer S, Ali S, Babar ZD. Preventive measures and management of COVID-19 in pregnancy. Drugs Ther Perspect 2020; 36(6): 246-9.
  14. de Sousa ÁFL, de Carvalho HEF, de Oliveira LB, Schneider G, Camargo ELS, Watanabe E, et al. Effects of COVID-19 infection during pregnancy and neonatal prognosis: What is the evidence? Int J Environ Res Public Health
    2020; 17(11): 4176.
  15. Goyal M, Singh P, Melana N. Review of care and management of pregnant women during COVID-19 pandemic. Taiwan J Obstet Gynecol 2020; 59(6): 791-4.
  16. López M, Gonce A, Meler E, Plaza A, Hernández S, Martinez-Portilla RJ, et al. Coronavirus disease 2019 in pregnancy: a clinical management protocol and considerations for practice. Fetal Diagn Ther 2020; 47(7): 519-28.
  17. Baud D, Greub G, Favre G, Gengler C, Jaton K, Dubruc E, et al. Second-trimester miscarriage in a pregnant woman with SARS-CoV-2 infection. JAMA 2020; 323(21): 2198-200.
  18. Rana MS, Usman M, Alam MM, Khalid A, Ikram A, Salman M, et al. First trimester miscarriage in a pregnant woman infected with COVID-19 in Pakistan. J Infect 2020; 82(1): e27-e28.
  19. Castro P, Matos AP, Werner H, Lopes FP, Tonni G, Araujo Júnior E. Covid-19 and pregnancy: an overview. Rev Bras Ginecol Obstet 2020; 42(7): 420-6.
  20. Di Mascio D, Khalil A, Saccone G, Rizzo G, Buca D, Liberati M, et al. Outcome of coronavirus spectrum infections (SARS, MERS, COVID-19) during pregnancy: a systematic review and meta-analysis. Am J Obstet Gynecol MFM 2020; 2(2): 100107.
  21. Dashraath P, Wong JLJ, Lim MXK, Lim LM, Li S, Biswas A, et al. Coronavirus disease 2019 (COVID-19) pandemic and pregnancy. Am J Obstet Gynecol 2020; 222(6): 521-31.
  22. Selim M, Mohamed S, Abdo M, Abdelhaffez A. Is COVID-19 similar in pregnant and non-pregnant women? Cureus 2020; 12(6): e8888.
  23. do Amaral WN, de Moraes CL, Rodrigues AP, Noll M, Arruda JT, Mendonça CR. Maternal coronavirus infections and neonates born to mothers with SARS-CoV-2: a systematic review. Healthcare 2020; 8(4): 511.
  24. Ghayda RA, Li H, Lee KH, Lee HW, Hong SH, Kwak M, et al. COVID-19 and adverse pregnancy outcome: a systematic review of 104 cases. J Clin Med 2020; 9(11): 3441.
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