Statistics

Number of Journals8
Number of Issues47
Number of Articles342
Article View77,832
PDF Download49,623
Ekraminasab, S., Manzourolhojeh, M. (2021). Prevalence of Sepsis among Iranian Newborns with Jaundice: A Meta-Analysis Based on Cross-Sectional Studies. Shahid Sadoughi University of Medical Sciences- Journal Management System, 4(2), 115-123. doi: 10.18502/wjpn.v4i2.8649
Sedigheh Ekraminasab; Mohammad Manzourolhojeh. "Prevalence of Sepsis among Iranian Newborns with Jaundice: A Meta-Analysis Based on Cross-Sectional Studies". Shahid Sadoughi University of Medical Sciences- Journal Management System, 4, 2, 2021, 115-123. doi: 10.18502/wjpn.v4i2.8649
Ekraminasab, S., Manzourolhojeh, M. (2021). 'Prevalence of Sepsis among Iranian Newborns with Jaundice: A Meta-Analysis Based on Cross-Sectional Studies', Shahid Sadoughi University of Medical Sciences- Journal Management System, 4(2), pp. 115-123. doi: 10.18502/wjpn.v4i2.8649
Ekraminasab, S., Manzourolhojeh, M. Prevalence of Sepsis among Iranian Newborns with Jaundice: A Meta-Analysis Based on Cross-Sectional Studies. Shahid Sadoughi University of Medical Sciences- Journal Management System, 2021; 4(2): 115-123. doi: 10.18502/wjpn.v4i2.8649

Prevalence of Sepsis among Iranian Newborns with Jaundice: A Meta-Analysis Based on Cross-Sectional Studies

World Journal of Peri and Neonatology
Volume 4, Issue 2, December 2021, Pages 115-123    PDF (457.3 K)
Document Type: Systematic Review
DOI: 10.18502/wjpn.v4i2.8649
Authors
Sedigheh Ekraminasab* 1, 2; Mohammad Manzourolhojeh3
1Mother and Newborn Health Research Center, Shahid Sadoughi University of Medical Sciences, Yazd, Iran
2Department of Hematology and Blood Banking, School of Allied Medical Sciences, Shahid Beheshti University of Medical Sciences, Tehran, Iran
3Department of Medical Laboratory Sciences, Gorgan Branch, Islamic Azad University, Gorgan, Iran
Abstract
Background: Jaundice is a common life-threatening disease in the neonates. Several factors play a role in the etiology of jaundice. Sepsis is a possible cause of jaundice after blood group incompatibility. Bacterial infection and jaundice may be associated with higher morbidity. To date there exists no systematic review and meta-analysis that evaluated the Prevalence of sepsis in Iranian newborns with jaundice. Thus, in this study we evaluated the prevalence of sepsis among Iranian newborns with jaundice.
Methods: A comprehensive literature search in Persian and English was performed on PubMed, Web of Sciences, Scopus, Google Scholar, Magiran and Scientific Information Database (SID) till July 2021. Data analysis was done by CMA version 2.0 software.
Results: A total of eight publications with 4434 newborns with jaundice out of approximately 105 retrieved articles were selected. 211 neonates had sepsis. Pooled data revealed that the overall prevalence of sepsis among Iranian newborns with jaundice was 4.7% (95% CI 0.041-0.202, P ≤ 0.001) and there was no publication bias.
Conclusion: This study showed that the prevalence of sepsis among Iranian newborns with jaundice was 4.7% and sepsis was a plausible reason of unexplained Hyperbilirubinemia among newborns with jaundice. To better understand the relationship between jaundice and sepsis, more studies with large sample sizes are needed.
Keywords
Sepsis; Neonates; Jaundice; Hyperbilirubinemia; Iranian; Prevalence
References
  1. Boskabadi H, Rakhshanizadeh F, Zakerihamidi M. Evaluation of maternal risk factors in neonatal hyperbilirubinemia. Arch Iran Med 2020; 23(2): 128-40.
  2. Olusanya BO, Ogunlesi TA, Kumar P, Boo NY, Iskander IF, de Almeida MF, et al. Management of late-preterm and term infants with hyperbilirubinaemia in resource-constrained settings. BMC Pediatr 2015; 15(1): 1-12.
  3. Zahed Pasha Y, Alizadeh-Tabari S, Zahed Pasha E, Zamani M. Etiology and therapeutic management of neonatal jaundice in Iran : a systematic review and meta-analysis. World J Pediatr 2020; 16(5): 480-93.
  4. Hossain M, Begum M, Ahmed S, Absar MN. Causes, Management and immediate complications of management of neonatal jaundice - A hospital-based study. J Enam Med Coll 2015; 5(2): 104-9.
  5. Olusanya BO, Teeple S, Kassebaum NJ. The contribution of neonatal jaundice to global child mortality: Findings from the GBD 2016 study. Pediatrics 2018; 141(2): e20171471.
  6. Olusanya BO, Osibanjo FB, Slusher TM. Risk factors for severe neonatal hyperbilirubinemia in low and middle-income countries: A systematic review and meta-analysis. PLoS One 2015; 10(2): e0117229.
  7. Das S, van Landeghem FKH. Clinicopathological spectrum of bilirubin encephalopathy/kernicterus. Diagnostics (Basel) 2019; 9(1): 24.
  8. Boskabadi H, Omidian M, Mafinejad S. Prevalence and clinical manifestation of glucose-6-phosphate dehydrogenase deficiency in newborns with hyperbilirubinemia in Mashhad, Iran. Maced J Med Sci 2010; 3(4): 383-7.
  9. Boskabadi H, Rakhshanizadeh F, Moradi A, Zakerihamidi M. Risk factors and causes of neonatal hyperbilirubinemia: A systematic review study. J Pediatr Rev 2020; 8(4): 211-22.
  10. Wan ASL, Mat Daud S, Teh SH, Choo YM, Kutty FM. Management of neonatal jaundice in primary care. Malaysian Fam Physician 2016; 11(2-3): 16-9.
  11. Kawasaki T. Update on pediatric sepsis: A review. J Intensive Care 2017; 5(1): 1-12.
  12. Singer M, Deutschman CS, Seymour C, Shankar-Hari M, Annane D, Bauer M, et al. The third international consensus definitions for sepsis and septic shock (sepsis-3). JAMA 2016; 315(8): 801-10.
  13. Fleischmann C, Scherag A, Adhikari NKJ, Hartog CS, Tsaganos T, Schlattmann P, et al. Assessment of global incidence and mortality of hospital-treated sepsis current estimates and limitations. Am J Respir Crit Care Med 2016; 193(3): 259-72.
  14. Ferdosian F, Jarahzadeh MH, Bahrami R, Nafei Z, Jafari M, Raee-ezzabadi A, et al. Association of IL-6 -174G > C polymorphism with susceptibility to childhood sepsis : A systematic review and meta-analysis. Fetal Pediatr Pathol 2021; 40(6): 638-652.
  15. Fleischmann-Struzek C, Goldfarb DM, Schlattmann P, Schlapbach LJ, Reinhart K, Kissoon N. The global burden of paediatric and neonatal sepsis: a systematic review. Lancet Respir Med 2018; 6(3): 223-30.
  16. Jarahzadeh MH, Jafari M, Seifi- N, Ferdosian F, Bahrami R, Raee-ezzabadi A, et al. Association of PAI-1 4G/5G and ACE I/D polymorphisms with susceptibility to pediatric sepsis : Evidence from a meta-analysis. Fetal Pediatr Pathol 2020:1-17.
  17. Chand N, Sanyal AJ. Sepsis-induced cholestasis. Hepatology 2007; 45(1): 230-41.
  18. Maamouri G, Khatami F, Mohammadzadeh A, Saeidi R, Farhat AS, Kiani MA, et al. Hyperbilirubinemia and neonatal infection. Int J Pediatr 2013; 1(1): 5-12.
  19. Shiva F, Ghotbi F. Neonatl jaundice and essential to evaluation sepsis in icterus neonatal. Research in Medicine 2002; 26(2):111-14. [In Persian].
  20. Hajebrahim Tehrani F, Valaie N. Incidence of septicemia and urinary tract infection in newborns with jaundice hospitalized in Mofid hospital. Feyz 2004; 7(4): 58-63. [In Persian].
  21. Javadi T, Mohsenzadeh A. Evaluation of the causes of jaundice in neonates admitted to Shahid Madani Hospital in Khorramabad in 2001. Yafte 2006; 7(4): 73-8. [In Persian].
  22. Koosha A, Rafizadeh B. Evaluation of neonatal indirect hyperbilirubinaemia at Zanjan Province of Iran in 2001-2003: prevalence of glucose-6-phosphate dehydrogenase deficiency. Singapore Med J 2007; 48(5): 424-8.
  23. Fallahi M, Basir MF, Ahmadpour Ghadi Kolaei M. Incidence of sepsis in neonates with indirect hyperbilirubinemia in Shohadaye Tajrish Hospital. Pajoohande 2009; 14 (1): 27-30. [In Persian].
  24. Mirfazeli A, Najafi l, et al. Causes of severe and indirect hyperbilirubinemia in neonates admitted to Taleghani Children's Hospital in Gorgan. J Gorgan Univ Med Sci 2010, 11(4): 82-86. [In Persian].
  25. Najib KS, Saki F, Hemmati F, Inaloo S. Incidence, risk factors and causes of severe neonatal hyperbilirubinemia in South of Iran (Fars Province). Iran Red Crescent Med J 2013;15(3):260–3.
  26. Boskabadi H, Zakerihamidi M, Bagheri F, Boskabadi A. Evaluation of the causes of neonatal jaundice, based on the infant’s age at disease onset and age at hospital admission. Tehran Univ Med J 2016; 73(10): 724-31. [In Persian].
  27. Lookzadeh MH, Bahrami R, Ekraminasab S. Prevalence of urinary tract infection in Iranian newborns with jaundice: A meta-analysis. World J Peri & Neonatol 2021; 4(1): 40-9.
  28. Hansen TWR, Wong RJ, Stevenson DK. Molecular physiology and pathophysiology of bilirubin handling by the blood, liver, intestine, and brain in the newborn. Physiol Rev 2020; 100(3): 1291-346.
  29. Liu Y, Sun X, Wang Y, Xing C, Li L, Zhou S. Evaluation of associated markers of neonatal pathological jaundice due to bacterial infection. Iran J Public Health 2021; 50(2): 333-40.
  30. Akbarian-Rad Z, Riahi SM, Abdollahi A, Sabbagh P, Ebrahimpour S, Javanian M, et al. Neonatal sepsis in Iran: A systematic review and meta-analysis on national prevalence and causative pathogens. PLoS One 2020; 15(1): e0227570.
  31. Hansen R, Gibson S, De Paiva Alves E, Goddard M, MacLaren A, Karcher AM, et al. Adaptive response of neonatal sepsis-derived Group B Streptococcus to bilirubin. Sci Rep 2018; 8(1): 6470.
Statistics
Article View: 321
PDF Download: 126


Journal Management System. Powered by Sinaweb