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Golshan-Tafti, M., Ekraminasab, S., Bahrami, R., Asadian, F. (2022). Mortality Rate in Hospitalized Pediatric Patients with COVID-19 Infection in Iran: A Systematic Review and Meta-Analysis. Shahid Sadoughi University of Medical Sciences- Journal Management System, 5(1), 30-39. doi: 10.18502/wjpn.v5i1.10126
Mohammad Golshan-Tafti; Sedigheh Ekraminasab; Reza Bahrami; Fatemeh Asadian. "Mortality Rate in Hospitalized Pediatric Patients with COVID-19 Infection in Iran: A Systematic Review and Meta-Analysis". Shahid Sadoughi University of Medical Sciences- Journal Management System, 5, 1, 2022, 30-39. doi: 10.18502/wjpn.v5i1.10126
Golshan-Tafti, M., Ekraminasab, S., Bahrami, R., Asadian, F. (2022). 'Mortality Rate in Hospitalized Pediatric Patients with COVID-19 Infection in Iran: A Systematic Review and Meta-Analysis', Shahid Sadoughi University of Medical Sciences- Journal Management System, 5(1), pp. 30-39. doi: 10.18502/wjpn.v5i1.10126
Golshan-Tafti, M., Ekraminasab, S., Bahrami, R., Asadian, F. Mortality Rate in Hospitalized Pediatric Patients with COVID-19 Infection in Iran: A Systematic Review and Meta-Analysis. Shahid Sadoughi University of Medical Sciences- Journal Management System, 2022; 5(1): 30-39. doi: 10.18502/wjpn.v5i1.10126

Mortality Rate in Hospitalized Pediatric Patients with COVID-19 Infection in Iran: A Systematic Review and Meta-Analysis

World Journal of Peri and Neonatology
Article 6, Volume 5, Issue 1, July 2022, Pages 30-39    PDF (463.92 K)
Document Type: Systematic Review
DOI: 10.18502/wjpn.v5i1.10126
Authors
Mohammad Golshan-Tafti1; Sedigheh Ekraminasab* 2, 3; Reza Bahrami4; Fatemeh Asadian5
1Department of Pediatrics, Islamic Azad University of Yazd, Yazd, Iran
2Mother and Newborn Health Research Center, Shahid Sadoughi University of Medical Sciences, Yazd, Iran
3Department of Hematology and Blood Banking, School of Allied Medical Sciences, Shahid Beheshti University of Medical Sciences, Tehran, Iran
4Neonatal Research Center, Shiraz University of Medical Sciences, Shiraz, Iran
5Department of Medical Laboratory Sciences, School of Paramedical Science, Shiraz University of Medical Sciences, Shiraz, Iran
Abstract
Background: There is little data on the mortality rate and severity of COVID-19 infection among pediatrics. This knowledge is particularly significant because pneumonia is the main underlying cause of death in children worldwide. This systematic review and meta-analysis aims to evaluate the mortality rate of COVID-19 in the pediatric population in Iran.
Methods: A systematic review and meta-analysis of the publications was conducted based on the PRISMA guidelines to search for COVID-19 child mortality. PubMed, Google Scholar, Embase, Medline databases, and Persian database were searched for publications on pediatric COVID-19 infections published in Iran with a focus on mortality in children with COVID -19 infection in Iran between January 1st to April 30th, 2021. Articles representing at least one Pediatric with and without comorbidities, COVID-19 infection, and informed outcomes were examined.
Results: Eight studies including three case series, and five retrospective cross-sectional studies altogether representing a total of 238 pediatric patients with COVID-19 were included in this meta-analysis. Of this population, 14 patients had died. In this study, the mean age of the study sample was 6.7 years. The mortality rate among children hospitalized with COVID-19 was 9% (95% CI 0.055-0.146). Also, children with comorbidities had a higher risk of COVID-19 related mortality.
Conclusion: Unlike adults, most infected children are asymptomatic and are not usually hospitalized. Children with underlying conditions are at increased risk of severe COVID-19 related mortality than children without underlying illness. More attention should be paid to children with comorbidities and children of young age.
Keywords
Mortality rate; COVID-19 Infection; Pediatric; Comorbidity; Meta-Analysis
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