Related Links
Statistics
| Number of Journals | 8 |
| Number of Issues | 52 |
| Number of Articles | 379 |
| Article View | 105,008 |
| PDF Download | 69,014 |
Evaluation of age-sex relationship on BUN and Cr variables; report of four-year mortality of hospitalized patients due to acute myocardial infarction | ||
| Cardiovascular Biomedicine | ||
| Volume 2, Issue 1, September 2022, Pages 51-56 PDF (351.47 K) | ||
| Document Type: original articles | ||
| DOI: 10.18502/cbj.v1i2.10593 | ||
| Authors | ||
| Shokouh Taghipour Zahir1; Seyed Hani Mosavi Bioki1; Maryam Rahimi Tesiye2; Parvin Fonooni Torshiz* 3; Negin Salehi4; Amir mohammad Babaiemahani5 | ||
| 1Faculty of Medicine Pathology Ward, Shahid Sadoughi Hospital, Shahid Sadoughi University of Medical Sciences, Yazd, Iran | ||
| 2Faculty of Life Science and Biotechnology, Shahid Beheshti University, Tehran, Iran | ||
| 3Faculty of Nursing and Midwifery, Shahid Sadoughi University, Yazd, Iran | ||
| 4School of Pharmacy and Pharmaceutical Sciences, Isfahan University of Medical Sciences, Isfahan, Iran | ||
| 5Biotechnology Research Center, International Campus, Shahid Sadoughi University of Medical Science, Yazd, Iran | ||
| Abstract | ||
| Objectives: Blood urea nitrogen (BUN) and serum creatinine (Cr) levels are the risk factors associated with prognosis in patients with the acute coronary syndrome. This study aimed to investigate whether BUN and Cr have a predictive value in patients diagnosed with acute myocardial infarction (AMI) and their mortality. Methods: This descriptive-analytical study was performed retrospectively by referring to the archives of Shahid Sadoughi Hospital in Yazd, Iran. The participants were 131 patients with acute myocardial infarction whose files were accessible from 2014 until 2018. Parameters such as age, sex, type of stroke, Cr and BUN levels at the time of admission, and outcome were examined. A questionnaire was used to collect data. Data analysis was performed using SPSS software version 21, and graphs were drawn with Sigma Plot software version 12.5. Results: Data analysis showed no significant difference between Cr and BUN levels between men and women (P = 0˃05). The levels of both of these factors elevated with age in the patients (BUN: P ≤ 0.01), (Cr: P ≤ 0.05). In addition, both Cr (P ≤ 0.05) and BUN (P ≤ 0.001) had higher levels in the deceased patients than in the discharged ones. Conclusions: The results revealed that in addition to elevated Cr and BUN, which are indicators of renal function, age is a significant risk factor in predicting mortality in AMI patients. | ||
| Keywords | ||
| Acute myocardial infarction; AMI; Blood urea nitrogen; Creatinine; Mortality | ||
| References | ||
|
1. Yao Y, Zhao J, Zhou X, et al. Potential role of a three-gene signature in predicting diagnosis in patients with myocardial infarction. Bioengineered. 2021;12(1):2734-49.
2. Boateng S, Sanborn T. Acute myocardial infarction. Dis Mon. 2013; 59(3):83-96.
3. Anderson JL, Morrow DA. Acute Myocardial Infarction. N Engl J Med. 2017;376(21):2053-64.
4. Mosa Farkhani E. Survival rate and its related factors in patients with acute myocardial infarction. Med J Mashhad Uni Med Sci. 2014;57(4): 636-46. 5. Lin H-J, Chao C-L, Chien K-L, et al. Elevated blood urea nitrogen-to-creatinine ratio increased the risk of hospitalization and all-cause death in patients with chronic heart failure. Clin Res Cardiol. 2009; 98(8):487-92.
6. Qian H, Tang C, Yan G. Predictive value of blood urea nitrogen/creatinine ratio in the long-term prognosis of patients with acute myocardial infarction complicated with acute heart failure. Medicine. 2019;98(11).
7. Richter B, Sulzgruber P, Koller L, et al. Blood urea nitrogen has additive value beyond estimated glomerular filtration rate for prediction of long-term mortality in patients with acute myocardial infarction. Eur J Intern Med. 2019; 59:84-90.
8. Horiuchi Y, Aoki J, Tanabe K, et al. A high level of blood urea nitrogen is a significant predictor for in-hospital mortality in patients with acute myocardial infarction. Int Heart J. 2018; 59(2): 263-271. 9. Rubinstein J, Sanford D. Treatment of Cardiorenal Syndrome. Cardiol Clin. 2019;37(3): 267-73.
10. Tung Y-C, Chang C-H, Chen Y-C, et al. Combined biomarker analysis for risk of acute kidney injury in patients with ST-segment elevation myocardial infarction. PloS one. 2015;10(4):e0125282.
11. Takaya Y, Yoshihara F, Yokoyama H, et al. Risk stratification of acute kidney injury using the blood urea nitrogen/creatinine ratio in patients with acute decompensated heart failure. Circ J. 2015;79(7): 1520-5.
12. Shiba N. Blood urea nitrogen/creatinine ratio in acute heart failure patients. Circulation Journal. 2015;79(7):1446-7.
13. Patschan D, Marahrens B, Jansch M, et al. Experimental Cardiorenal Syndrome Type 3: What Is Known so Far? J Clin Med Res. 2022; 14(1):22-27.
14. Schefold JC, Lainscak M, Hodoscek LM, et al. Single baseline serum creatinine measurements predict mortality in critically ill patients hospitalized for acute heart failure. ESC Heart Failure. 2015;2(4):122-8.
15. Murata A, Kasai T, Matsue Y, Matsumoto H, et al. Relationship between blood urea nitrogen-to-creatinine ratio at hospital admission and long-term mortality in patients with acute decompensated heart failure. Heart and vessels. 2018;33(8):877-85.
16. Saygitov RT, Glezer MG, Semakina SV. Blood urea nitrogen and creatinine levels at admission for mortality risk assessment in patients with acute coronary syndromes. Emerg Med J. 2010; 27(2):105-9.
17. Smith GL, Shlipak MG, Havranek EP, et al. Serum urea nitrogen, creatinine, and estimators of renal function: mortality in older patients with cardiovascular disease. Arch Intern Med. 2006; 166(10):1134-42.
18. Aronson D, Hammerman H, Beyar R, et al. Serum blood urea nitrogen and long-term mortality in acute ST-elevation myocardial infarction. Int J Cardiol. 2008; 127(3):380-5.
19. Kirtane AJ, Leder DM, Waikar SS, et al. Serum blood urea nitrogen as an independent marker of subsequent mortality among patients with acute coronary syndromes and normal to mildly reduced glomerular filtration rates. J Am Coll Cardiol. 2005; 45(11):1781-6.
20. Yamaguchi J, Kasanuki H, Ishii Y, et al. Serum Creatinine on Admission Predicts Long-Term Mortality in Acute Myocardial Infarction Patients Undergoing Successful Primary Angioplasty Data From the Heart Institute of Japan Acute Myocardial Infarction (HIJAMI) Registry. Circ J. 2007; 71(9): 1354-9.
21. Granger CB, Goldberg RJ, Dabbous O, et al. Predictors of hospital mortality in the global registry of acute coronary events. Archives of internal medicine. Arch Intern Med. 2003; 163(19):2345-53.
22. Núñez J, Miñana G, Santas E, et al. Cardiorenal syndrome in acute heart failure: revisiting paradigms. Rev Esp Cardiol (Engl Ed). 2015; 68(5):426-35.
23. Metra M, Davison B, Bettari L, et al. Is worsening renal function an ominous prognostic sign in patients with acute heart failure? The role of congestion and its interaction with renal function. Circ Heart Fail. 2012;5(1):54-62.
24. Brisco MA, Coca SG, Chen J, et al. Blood urea nitrogen/creatinine ratio identifies a high-risk but potentially reversible form of renal dysfunction in patients with decompensated heart failure. Circ Heart Fail. 2013; 6(2):233-9.
25. Aronson D, Mittleman MA, Burger AJ. Elevated blood urea nitrogen level as a predictor of mortality in patients admitted for decompensated heart failure. Am J Med. 2004; 116(7): 466-73.
26. Massari F, Scicchitano P, Iacoviello M, et al. Multiparametric approach to congestion for predicting long-term survival in heart failure. J Cardiol. 2020; 75(1): 47-52.
27. Matsue Y, van der Meer P, Damman K, et al. Blood urea nitrogen-to-creatinine ratio in the general population and in patients with acute heart failure. Heart. 2017;103(6):407-13. | ||
|
Statistics Article View: 263 PDF Download: 102 |
||