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Dastgheib, S., Asadian, F., Tahooni, A., Bahrami, R., Noorishadkam, M., Mirjalili, S., Neamatzadeh, H. (2022). Genetic Association between ITPKC rs28493229 Polymorphism and Susceptibility to Kawasaki Disease: A Meta-Analysis. Shahid Sadoughi University of Medical Sciences- Journal Management System, 5(2), 83-95. doi: 10.18502/wjpn.v5i2.11995
Seyed Alireza Dastgheib; Fatemeh Asadian; Azadeh Tahooni; Reza Bahrami; Mahmood Noorishadkam; Seyed Reza Mirjalili; Hossein Neamatzadeh. "Genetic Association between ITPKC rs28493229 Polymorphism and Susceptibility to Kawasaki Disease: A Meta-Analysis". Shahid Sadoughi University of Medical Sciences- Journal Management System, 5, 2, 2022, 83-95. doi: 10.18502/wjpn.v5i2.11995
Dastgheib, S., Asadian, F., Tahooni, A., Bahrami, R., Noorishadkam, M., Mirjalili, S., Neamatzadeh, H. (2022). 'Genetic Association between ITPKC rs28493229 Polymorphism and Susceptibility to Kawasaki Disease: A Meta-Analysis', Shahid Sadoughi University of Medical Sciences- Journal Management System, 5(2), pp. 83-95. doi: 10.18502/wjpn.v5i2.11995
Dastgheib, S., Asadian, F., Tahooni, A., Bahrami, R., Noorishadkam, M., Mirjalili, S., Neamatzadeh, H. Genetic Association between ITPKC rs28493229 Polymorphism and Susceptibility to Kawasaki Disease: A Meta-Analysis. Shahid Sadoughi University of Medical Sciences- Journal Management System, 2022; 5(2): 83-95. doi: 10.18502/wjpn.v5i2.11995

Genetic Association between ITPKC rs28493229 Polymorphism and Susceptibility to Kawasaki Disease: A Meta-Analysis

Journal of Research in Maternal and Child Health
Article 5, Volume 5, Issue 2, December 2022, Pages 83-95    PDF (774.73 K)
Document Type: Systematic Review
DOI: 10.18502/wjpn.v5i2.11995
Authors
Seyed Alireza Dastgheib1; Fatemeh Asadian2; Azadeh Tahooni3; Reza Bahrami* 4; Mahmood Noorishadkam5, 6; Seyed Reza Mirjalili5, 6; Hossein Neamatzadeh6, 7
1Department of Medical Genetics, School of Medicine, Shiraz University of Medical Sciences, Shiraz, Iran
2Department of Medical Laboratory Sciences, School of Paramedical Science, Shiraz University of Medical Sciences, Shiraz, Iran
3Department of Cardiology, Firoozgar Hospital Research Center, Iran University of Medical Sciences, Tehran, Iran
4Neonatology Research Center, Shiraz University of Medical Sciences, Shiraz, Iran
5Department of Pediatrics, Shahid Sadoughi University of Medical Sciences, Yazd, Iran
6Mother and Newborn Health Research Center, Shahid Sadoughi University of Medical Sciences, Yazd, Iran
7Department of Medical Genetics, Shahid Sadoughi University of Medical Sciences, Yazd, Iran
Abstract
Background: Studies investigating the association between ITPKC rs28493229 polymorphisms and Kawasaki disease (KD) risk found inconsistent data. Thus, we performed this meta-analysis to combine and analyze the available studies to get a precise estimation of the association.
Methods: Relevant studies identified in the PubMed, Web of Science, Scopus, and CNKI databases were used to perform a meta-analysis. Pooled odds ratios (OR) with a 95% confidence interval (95% CI) were calculated under fixed- and random-effects models to appraise the association.
Results: A total of eight case-control studies with 2,721 KD cases and 5,307 controls were selected. The results showed a statistically significant association between ITPKC rs28493229 polymorphism and an increased risk of KD under all five genetic models, i.e., allele (C vs. G: OR = 1.434, 95% CI 1.209-1.700, P ≤ 0.001), homozygote (CC vs. GG: OR = 2.085, 95% CI 1.423-3.055, P ≤ 0.001), heterozygote (CG vs. GG: OR = 1.530, 95% CI 1.359-1.722, P ≤ 0.001), dominant (CC+CG vs. GG: OR = 1.490, 95% CI 1.229-1.806, P ≤ 0.001), and recessive (CC vs. CG + GG: OR = 1.799, 95% CI 1.231-2.629, P = 0.002) in the overall population. When stratified by country, there was a significant association among Taiwanese.
Conclusion: Our meta-analysis results supported that the ITPKC rs28493229 polymorphism is strongly associated with susceptibility to KD.
Keywords
Kawasaki Disease; ITPKC Gene; Vasculitis; Polymorphism; Association
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