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Lookzadeh, M., Alipour, M., Vakili Zarch, A., Ekraminasab, S. (2022). Prevalence of Hypertrophic Cardiomyopathy in Neonates of Diabetic Mothers: A Six-month Follow-up Study. Shahid Sadoughi University of Medical Sciences- Journal Management System, 5(2), 58-64. doi: 10.18502/wjpn.v5i2.11992
Mohamad Hosein Lookzadeh; Mohammad Reza Alipour; Abbas Vakili Zarch; Sedigheh Ekraminasab. "Prevalence of Hypertrophic Cardiomyopathy in Neonates of Diabetic Mothers: A Six-month Follow-up Study". Shahid Sadoughi University of Medical Sciences- Journal Management System, 5, 2, 2022, 58-64. doi: 10.18502/wjpn.v5i2.11992
Lookzadeh, M., Alipour, M., Vakili Zarch, A., Ekraminasab, S. (2022). 'Prevalence of Hypertrophic Cardiomyopathy in Neonates of Diabetic Mothers: A Six-month Follow-up Study', Shahid Sadoughi University of Medical Sciences- Journal Management System, 5(2), pp. 58-64. doi: 10.18502/wjpn.v5i2.11992
Lookzadeh, M., Alipour, M., Vakili Zarch, A., Ekraminasab, S. Prevalence of Hypertrophic Cardiomyopathy in Neonates of Diabetic Mothers: A Six-month Follow-up Study. Shahid Sadoughi University of Medical Sciences- Journal Management System, 2022; 5(2): 58-64. doi: 10.18502/wjpn.v5i2.11992

Prevalence of Hypertrophic Cardiomyopathy in Neonates of Diabetic Mothers: A Six-month Follow-up Study

World Journal of Peri and Neonatology
Article 2, Volume 5, Issue 2, December 2022, Pages 58-64    PDF (267.94 K)
Document Type: Original Article
DOI: 10.18502/wjpn.v5i2.11992
Authors
Mohamad Hosein Lookzadeh1; Mohammad Reza Alipour* 2; Abbas Vakili Zarch3; Sedigheh Ekraminasab1, 4
1Mother and Newborn Health Research Center, Shahid Sadoughi University of Medical Sciences, Yazd, Iran
2Yazd Cardiovascular Research Center, Shahid Sadoughi University of Medical Sciences, Yazd, Iran
3Department of Surgery, School of Medicine, Shahid Sadoughi University of Medical Sciences, Yazd, Iran
4Laboratory Hematology and Blood Banking Department, School of Allied Medical Sciences, Shahid Beheshti University of Medical Sciences, Tehran, Iran
Abstract
Background: Hypertrophic cardiomyopathy (HCM) is known to be the most common cardiac disorder in fetuses of diabetic mothers, especially when diabetes is not controlled in pregnancy. This study aimed as to estimate the prevalence of HCM in neonates born to diabetic mothers and to evaluate therapeutic interventions with follow-up after six months. We also focused on the possible association of neonatal HCM with the maternal type of diabetes.
Methods: A cross-sectional study was conducted between October 2016, and September 2017, in the Cardiac Clinic of Yazd, a city in the center of Iran. The subjects were 150 neonates of mothers with diabetes. We determined HCM through fetal echocardiography before treatment and assessed the maternal and fetal factors. Finally, after a 6-month follow-up period, the data were analyzed statistically.
Results: According to the results, the prevalence of HCM in neonates of diabetic mothers was 14% (P < 0.0001). The results showed that there is a relationship between maternal uncontrolled diabetes and the incidence of HCM in the infant (P < 0.0001), but there is no relationship between the type of diabetes and the incidence of HCM. Our results also showed that propranolol was effective in improving HCM, and spontaneous recovery of HCM was low in infants.
Conclusion: We concluded that controlling maternal diabetes has the greatest effect on the prevention of HCM in neonates. Also, neonates of diabetic mothers need more heart tests and follow-ups. Therefore, more studies on the effects of maternal diabetes-induced HCM in neonates are needed.
Keywords
Cardiomyopathy; Diabetes mellitus; Heart diseases; Fetal echocardiography; Propranolol; Gestational diabetes
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