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Eskandary, A., Moazedi, A. (2023). The Combined Effect of Donepezil and Lovastatin on the Electrical Activity of Hippocampal Pyramidal Neurons in a rat model of Alzheimer’s disease. Shahid Sadoughi University of Medical Sciences- Journal Management System, 3(2), 87-96. doi: 10.18502/aptj.v3i2.13461
Azade Eskandary; Ahmad Ali Moazedi. "The Combined Effect of Donepezil and Lovastatin on the Electrical Activity of Hippocampal Pyramidal Neurons in a rat model of Alzheimer’s disease". Shahid Sadoughi University of Medical Sciences- Journal Management System, 3, 2, 2023, 87-96. doi: 10.18502/aptj.v3i2.13461
Eskandary, A., Moazedi, A. (2023). 'The Combined Effect of Donepezil and Lovastatin on the Electrical Activity of Hippocampal Pyramidal Neurons in a rat model of Alzheimer’s disease', Shahid Sadoughi University of Medical Sciences- Journal Management System, 3(2), pp. 87-96. doi: 10.18502/aptj.v3i2.13461
Eskandary, A., Moazedi, A. The Combined Effect of Donepezil and Lovastatin on the Electrical Activity of Hippocampal Pyramidal Neurons in a rat model of Alzheimer’s disease. Shahid Sadoughi University of Medical Sciences- Journal Management System, 2023; 3(2): 87-96. doi: 10.18502/aptj.v3i2.13461

The Combined Effect of Donepezil and Lovastatin on the Electrical Activity of Hippocampal Pyramidal Neurons in a rat model of Alzheimer’s disease

Advances in Pharmacology and Therapeutics Journal
Article 4, Volume 3, Issue 2 - Serial Number 5, August 2023, Pages 87-96    PDF (544.77 K)
Document Type: Original Article
DOI: 10.18502/aptj.v3i2.13461
Authors
Azade Eskandary* ; Ahmad Ali Moazedi
Abstract
Background: Donepezil, a noncompetitive acetylcholinesterase inhibitor, is prescribed to treat mild to moderate Alzheimer's disease but it only has moderate performance. Therefore, combination therapies are more effective. There is much evidence suggesting that statins have neuroprotective effects on neurological disorders including Alzheimer's disease. The present study aimed to investigate the combined effects of Donepezil and Lovastatin on the activity of the pyramidal neurons of the CA1 hippocampus.
Methods: In the present experiment study, adult male rats were divided into 3 groups: Nucleus Basalis Magnocellularis (NBM) lesion (which received electrically- induced lesion (0.5 mA, 3s) in NBM) group, NBM lesion + injection Donepezil 5mg/kg-Lovastatin 10mg/kg, NBM lesion+ injection Donepezil 15mg/kg-Lovastatin 30mg/kg. Spontaneous activity of pyramidal neurons in CA1 region to injection of Donepezil-Lovastatin was investigated in a rat model of Alzheimer's disease.
Results: The results of this study showed that electrical lesion of NBM leads to a decrease in the activity frequency of pyramidal neurons in the CA1 region. Administration of Donepezil 5mg/kg-Lovastatin 10mg/kg increased the frequency of pyramidal neurons in rat model of Alzheimer's disease.
Conclusion: The results of this study suggest that co-administration of Donepezil-Lovastatin (low doses) increases the activity of the CA1 pyramidal neurons in a rat model of Alzheimer’s disease.
Keywords
Alzheimer’s Disease; Single Unit Recording; Hippocampus; Donepezil; Lovastatin; Rat
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