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Neamatzadeh, H., Ekraminasab, S., Bahrami, R., Asadian, F. (2023). The Mechanism of Action of Cotoneaster Manna, an Iranian Herbal Medicine, in the Treatment of Neonatal Jaundice. Shahid Sadoughi University of Medical Sciences- Journal Management System, 6(1), 49-55. doi: 10.18502/wjpn.v6i1.14252
Hossein Neamatzadeh; Sedigheh Ekraminasab; Reza Bahrami; Fatemeh Asadian. "The Mechanism of Action of Cotoneaster Manna, an Iranian Herbal Medicine, in the Treatment of Neonatal Jaundice". Shahid Sadoughi University of Medical Sciences- Journal Management System, 6, 1, 2023, 49-55. doi: 10.18502/wjpn.v6i1.14252
Neamatzadeh, H., Ekraminasab, S., Bahrami, R., Asadian, F. (2023). 'The Mechanism of Action of Cotoneaster Manna, an Iranian Herbal Medicine, in the Treatment of Neonatal Jaundice', Shahid Sadoughi University of Medical Sciences- Journal Management System, 6(1), pp. 49-55. doi: 10.18502/wjpn.v6i1.14252
Neamatzadeh, H., Ekraminasab, S., Bahrami, R., Asadian, F. The Mechanism of Action of Cotoneaster Manna, an Iranian Herbal Medicine, in the Treatment of Neonatal Jaundice. Shahid Sadoughi University of Medical Sciences- Journal Management System, 2023; 6(1): 49-55. doi: 10.18502/wjpn.v6i1.14252

The Mechanism of Action of Cotoneaster Manna, an Iranian Herbal Medicine, in the Treatment of Neonatal Jaundice

World Journal of Peri and Neonatology
Article 6, Volume 6, Issue 1, December 2023, Pages 49-55    PDF (423.37 K)
Document Type: Scientific Review
DOI: 10.18502/wjpn.v6i1.14252
Authors
Hossein Neamatzadeh1, 2; Sedigheh Ekraminasab* 1, 3; Reza Bahrami4; Fatemeh Asadian5
1Mother and Newborn Health Research Center, Shahid Sadoughi Hospital, School of Medicine, Shahid Sadoughi University of Medical Sciences, Yazd, Iran
2Department of Medical Genetics, School of Medicine, Shahid Sadoughi University of Medical Sciences, Yazd, Iran
3Department of Hematology and Blood Banking, School of Allied Medical Sciences, Shahid Beheshti University of Medical Sciences, Tehran, Iran
4Neonatal Research Center, Shiraz University of Medical Sciences, Shiraz, Iran
5Department of Medical Laboratory Sciences, School of Paramedical Science, Shiraz University of Medical Sciences, Shiraz, Iran
Abstract
Background: Neonatal jaundice is a common clinical problem caused by the deposition of bilirubin in the tissue. Natural products have long been used to treat jaundice, and Iranian medicine can be a good source of natural treatments for this purpose. In this study, we investigate the mechanism of the effect of Cotoneaster, an Iranian herbal medicine, in the treatment of jaundice in neonates.
Methods: We investigated every article that evaluated Purgative manna, Cotoneaster manna, or Cotoneaster in the treatment of neonatal jaundice. We searched the databases of PubMed, Scopus, Web of Sciences, SciELO, CNKI, and Google Scholar for English articles, and a search was also done in Persian in Magiran and Scientific Information Database (SID) published until August 2023.
Results: The exact mechanism of Cotoneaster in reducing jaundice is not known, but the following mechanisms have been suggested .The most common mechanisms include increased urination, increased bile excretion from the liver, and increased defecation, as well as neutralizing the effects of oxidative agents and free radicals.
Conclusion: Considering that most studies have stated that Cotoneaster combined with phototherapy is effective in treating jaundice and herbal medicines alone cannot treat jaundice. Therefore, identifying the mechanism of Cotoneaster in reducing jaundice can lead to the creation of methods to strengthen its effect. More detailed biochemical and pharmacological studies are needed to understand the mechanism of action of Cotoneaster in reducing neonatal jaundice.
Keywords
Jaundice; Bilirubin; Purgative manna; Infant; Oxidants; Phototherapy
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