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Inflammatory biomarkers as predictors of calcific aortic stenosis severity: examining platelet to lymphocyte and neutrophil to lymphocyte ratios | ||
| Cardiovascular Biomedicine | ||
| Volume 3, Issue 2, December 2023, Pages 18-24 PDF (903.92 K) | ||
| Document Type: original articles | ||
| DOI: 10.18502/cbj.v3i2.15174 | ||
| Authors | ||
| Allahyar Golabchi1; Davoud Gharakhani2; Maryam Baghbeheshti3; Hamidreza Gilasi4; Amirmasoud Jafari1; Amir Mir-Mohammad Sadeghi5; Hamidreza Mohammadi* 3; Seyed Mohammad Mirhosseini3 | ||
| 1Department of Cardiology, Shahid Beheshti Hospital, Kashan University of Medical Sciences, Kashan, Iran | ||
| 2Department of Surgery, school of medicine, Kashan University of Medical Sciences, Kashan, Iran | ||
| 3Yazd Cardiovascular Research Center, Non-communicable Diseases Research Institute, Shahid Sadoughi University of Medical Sciences, Yazd, Iran | ||
| 4Department of Biostatistics and Epidemiology, Faculty of Health, Kashan University of Medical Sciences, Kashan, Iran | ||
| 5Department of Surgery, Isfahan University of Medical Sciences, Isfahan, Iran | ||
| Abstract | ||
| Objectives: Platelet-to-lymphocyte ratio (PLR) and neutrophil-to-lymphocyte ratio (NLR) are novel inflammatory markers known for inflammatory and cardiovascular diseases. This study aimed to examine PLR and NLR as predictors of calcification aortic stenosis (CAS) severity. Methods: This study investigated a total of 155 individuals who were referred to Chamran Heart Center in Esfahan, Iran between 2018 and 2019. The participants included 53 patients with severe AS, 50 patients with mild to moderate AS, and 52 individuals as a control group. The severity of aortic stenosis was evaluated in all participants using echocardiography. The study also calculated the PLR and NLR from CBC. Results: The results of this study indicate that there was no significant difference in PLR among those with severe AS (108±66), mild to moderate AS (103±43), and the control group (110±50) (p=0.813). However, the NLR was significantly higher in those with severe AS (3.13±2.3) compared to mild to moderate AS (2.08±0.7) and the control group (2.1±1.3) (p=0.019). Age and diabetes mellitus were found to be significant and independent factors correlated with PLR, while the severity of AS was not. Additionally, severe AS was found to be an independent predictor of NLR, along with age and sex. Conclusions: This study elucidated the intricate relationship between inflammatory markers and CAS, emphasizing the significance of NLR as an indicator of pro-inflammatory and anti-inflammatory contrast. Surprisingly, PLR exhibited no relationship with CAS severity. we suggest that future studies examine the effect of ethnic variation on the relationship between inflammatory markers and CAS. Also, explore the potential impact of additional inflammatory markers on new indices that may provide stronger predictive value for CAS severity. | ||
| Keywords | ||
| Calcific aortic stenosis; Platelet to lymphocyte ratio; Neutrophil to lymphocyte ratio; echocardiography | ||
| References | ||
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1.Erdoğan M, Öztürk S, Kardeşler B, et al. The relationship between calcific severe aortic stenosis and systemic immune-inflammation index. Echocardiography. 2021;38(5):737-744.
2.Chan KL, Dumesnil JG, Tam J, et al. Effect of rosuvastatin on C-reactive protein and progression of aortic stenosis. Am Heart J. 2011;161(6):1133-9.
3.Shvartz V, Sokolskaya M, Ispiryan A, et al. The Role of Novel Biomarkers of Systemic Inflammation in the Development of Early Hospital Events after Aortic Valve Replacement in Patients with Aortic Stenosis. Life. 2023;13(6):1395.
4.Erkhem-Ochir B, Tatsuishi W, Yokobori T, et al. Inflammatory and immune checkpoint markers are associated with the severity of aortic stenosis. JTCVS Open. 2020;5:1-12.
5.Efe TH, Gayretli Yayla K, Yayla C, et al. Calcific aortic stenosis and its correlation with a novel inflammatory marker, the lymphocyte/monocyte ratio. Rev Port Cardiol. 2016;35(11):573-578.
6.Edem E, Reyhanoğlu H, Küçükukur M, et al. Predictive value of platelet-to-lymphocyte ratio in severe degenerative aortic valve stenosis. J Res Med Sci. 2016;21:93.
7.Akboga MK, Canpolat U, Yayla C, et al. Association of Platelet to Lymphocyte Ratio With Inflammation and Severity of Coronary Atherosclerosis in Patients With Stable Coronary Artery Disease. Angiology. 2016;67(1):89-95.
8.Erre GL, Paliogiannis P, Castagna F, et al. Meta-analysis of neutrophil-to lymphocyte and platelet-to-lymphocyte ratio in rheumatoid arthritis. Eur J Clin Invest. 2019;49(1):e13037.
9.Li B, Zhou P, Liu Y, et al. Platelet-to-lymphocyte ratio in advanced Cancer: Review and meta-analysis. Clin Chim Acta. 2018;483:48-56.
10.Qin B, Ma N, Tang Q, et al. Neutrophil to lymphocyte ratio (NLR) and platelet to lymphocyte ratio (PLR) were useful markers in assessment of inflammatory response and disease activity in SLE patients. Mod Rheumatol. 2016;26(3):372-6.
11.Yolbas S, Yildirim A, Gozel N, et al. Hematological Indices May Be Useful in the Diagnosis of Systemic Lupus Erythematosus and in Determining Disease Activity in Behçet's Disease. Med Princ Pract. 2016;25(6):510-516.
12.Zengin O, Onder ME, Kalem A, et al. New inflammatory markers in early rheumatoid arthritis. Z Rheumatol. 2018;77(2):144-150.
13.Mercan R, Bitik B, Tufan A, et al. The Association Between Neutrophil/Lymphocyte Ratio and Disease Activity in Rheumatoid Arthritis and Ankylosing Spondylitis. J Clin Lab Anal. 2016;30(5):597-601.
14.Fihn SD, Gardin JM, Abrams J, et al. 2012 ACCF/AHA/ACP/AATS/PCNA/SCAI/STS Guideline for the diagnosis and management of patients with stable ischemic heart disease: a report of the American College of Cardiology Foundation/American Heart Association Task Force on Practice Guidelines, and the American College of Physicians, American Association for Thoracic Surgery, Preventive Cardiovascular Nurses Association, Society for Cardiovascular Angiography and Interventions, and Society of Thoracic Surgeons. J Am Coll Cardiol. 2012;60(24):e44-e164.
15.Baumgartner HC, Hung JC-C, Bermejo J, et al. Recommendations on the echocardiographic assessment of aortic valve stenosis: a focused update from the European Association of Cardiovascular Imaging and the American Society of Echocardiography. Eur Heart J Cardiovasc Imaging. 2017;18(3):254-275.
16.Nishimura RA, Otto CM, Bonow RO, et al. 2014 AHA/ACC guideline for the management of patients with valvular heart disease: a report of the American College of Cardiology/American Heart Association Task Force on Practice Guidelines. J Am Coll Cardiol. 2014;63(22):e57-185.
17.Yayla Ç, Açikgöz SK, Yayla KG, et al. The association between platelet-to-lymphocyte ratio and inflammatory markers with the severity of aortic stenosis. Biomark Med. 2016;10(4):367-73.
18.Mertoglu C, Gunay M. Neutrophil-Lymphocyte ratio and Platelet-Lymphocyte ratio as useful predictive markers of prediabetes and diabetes mellitus. Diabetes Metab Syndr. 2017;11:S127-S131.
19.Küçükseymen S, Çağırcı G, Güven R, et al. Is neutrophyl to lymphocyte ratio really a useful marker for all grades of degenerative aortic stenosis? Turk Kardiyol Dern Ars. 2017;45(6): 506-513.
20.Edem E, Reyhanoğlu H, Küçükukur M, et al. Predictive value of platelet-to-lymphocyte ratio in severe degenerative aortic valve stenosis. J Res Med Sci. 2016;21:93.
21.Ghasemi AA. Comparison of Laminectomy Alone and Laminectomy with Fusion in Patients with Lumbar Canal Stenosis. JBUMS. 2014;16(5):20-24.
22.Im Cho K, Cho SH, Her A-Y, et al. Prognostic utility of neutrophil-to-lymphocyte ratio on adverse clinical outcomes in patients with severe calcific aortic stenosis. PloS one. 2016;11(8):e0161530. | ||
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