Statistics

Number of Journals8
Number of Issues52
Number of Articles383
Article View118,381
PDF Download87,156
Mirhosseini, N., Noorishadkam, M., Mohammad Amoli, M., Khosravinejad, A. (2024). Four Patients with Neonatal Diabetes Mellitus and their Outcomes: A Case Series. Shahid Sadoughi University of Medical Sciences- Journal Management System, 6(2), 107-112. doi: 10.18502/wjpn.v6i2.15492
Naser Ali Mirhosseini; Mahmood Noorishadkam; Mahsa Mohammad Amoli; Amir Hossein Khosravinejad. "Four Patients with Neonatal Diabetes Mellitus and their Outcomes: A Case Series". Shahid Sadoughi University of Medical Sciences- Journal Management System, 6, 2, 2024, 107-112. doi: 10.18502/wjpn.v6i2.15492
Mirhosseini, N., Noorishadkam, M., Mohammad Amoli, M., Khosravinejad, A. (2024). 'Four Patients with Neonatal Diabetes Mellitus and their Outcomes: A Case Series', Shahid Sadoughi University of Medical Sciences- Journal Management System, 6(2), pp. 107-112. doi: 10.18502/wjpn.v6i2.15492
Mirhosseini, N., Noorishadkam, M., Mohammad Amoli, M., Khosravinejad, A. Four Patients with Neonatal Diabetes Mellitus and their Outcomes: A Case Series. Shahid Sadoughi University of Medical Sciences- Journal Management System, 2024; 6(2): 107-112. doi: 10.18502/wjpn.v6i2.15492

Four Patients with Neonatal Diabetes Mellitus and their Outcomes: A Case Series

Journal of Research in Maternal and Child Health
Volume 6, Issue 2, June 2024, Pages 107-112    PDF (553.63 K)
Document Type: Case Report
DOI: 10.18502/wjpn.v6i2.15492
Authors
Naser Ali Mirhosseini1, 2, 3; Mahmood Noorishadkam3; Mahsa Mohammad Amoli4; Amir Hossein Khosravinejad* 2
1Children Growth Disorder Research Center, Shahid Sadoughi University of Medical Sciences, Yazd, Iran
2Department of Pediatrics, School of Medicine, Shahid Sadoughi University of Medical Sciences, Yazd, Iran
3Mother and Newborn Health Research Center, Shahid Sadoughi University of Medical Sciences, Yazd, Iran
4Metabolic Disorders Research Center, Endocrinology and Metabolism Mulecular-Cellular Sciences Institute, Tehran University of Medical Sciences, Tehran, Iran
Abstract
Background: Neonatal diabetes mellitus (NDM) is a severe type of glucose metabolism disorder that appears in the first months of life and mostly presents with symptoms such as dehydration, inability to gain weight, and in extreme cases, ketoacidosis and coma. Strong evidence shows the benefits of early molecular tests that investigate variability in kATP channels such as KCNJ11, ABCC8, INS gene mutations, and 6q24 abnormalities. In the presence of these genomics changes, switching from Insulin treatment toward high-dose oral sulfonylurea can enhance the course of treatment, prognosis, and quality of life.
Case Report: In this study, we report four cases of neonatal diabetes with different symptoms who were referred to Shahid Sadoughi Medical Center in Yazd, Iran.
Conclusion: The diagnosis and treatment of NDM is a good model for implementing patient-centered and personalized medicine. For all patients with diabetes diagnosed before the 6th month of their age (even the 12th month), genetic testing should be considered.
Keywords
Neonatal diabetes mellitus; Glucose metabolism disorder; Insulin; Genetic testing
References
  1. Ambler GR, Cameron FJ, Joshi K, Wherrett DK. Diabetes Mellitus. In: Dattani MT, Brook CGD, editors. Brook’s clinical pediatric endocrinology. 7th Hoboken, New Jersey: Wiley; 2019. p. 642.
  2. Greeley SAW, McCauley MK, Philipson LH, Sperling MA. Monogenic diabetes mellitus: Neonatal diabetes and maturity-onset diabetes of the young. In: Sperling MA, editor. Sperling pediatric endocrinology. 5th Amsterdam, Netherlands: Elsevier; 2020. p. 279.
  3. Nansseu JRN, Ngo-Um SS, Balti E V. Incidence, prevalence and genetic determinants of neonatal diabetes mellitus: a systematic review and meta-analysis protocol. Syst Rev 2016; 5(1): 188.
  4. Wirth M, Jellimann JM, Jellimann S, Hascoët JM. Neonatal diabetes mellitus: improved screening and early management of an underestimated disease. Clin Case Rep 2017; 6(1): 18-22.
  5. De Franco E, Flanagan SE, Houghton JAL, Allen HL, MacKay DJG, Temple IK, et al. The effect of early, comprehensive genomic testing on clinical care in neonatal diabetes: an international cohort study. Lancet 2015; 386(9997): 957-63.
  6. Poon SWY, Chung BHY, Tsang MHY, Tung JYL. Successful transition from insulin to sulphonylurea in a child with neonataldiabetes mellitus diagnosed beyond six months of age due to C42R mutation in theKCNJ11 gene. Clin Pediatr Endocrinol 2022; 31(3): 168-71.
  7. Sagen JV, Ræder H, Hathout E, Shehadeh N, Gudmundsson K, Bævre H, et al. Permanent neonatal diabetes due to mutations in KCNJ11 encoding Kir6.2: patient characteristics and initial response to sulfonylurea therapy. Diabetes 2004; 53(10): 2713-8.
  8. Greeley SAW, Tucker SE, Naylor RN, Bell GI, Philipson LH. Neonatal diabetes mellitus: A model for personalized medicine. Trends Endocrinol Metab 2010; 21(8): 464-72.
Statistics
Article View: 168
PDF Download: 123


Journal Management System. Powered by Sinaweb