Statistics

Number of Journals8
Number of Issues52
Number of Articles381
Article View111,442
PDF Download76,508
Haghaninejad, H., Banifatemeh, S., Mohammadi, H., Razavi-Ratki, S., Nafisi Moghadam, R., Namiranian, N., Taheri Asl, G. (2024). The role of serum uric acid in predicting left ventricular function and outcomes in patients with STEMI following PCI. Shahid Sadoughi University of Medical Sciences- Journal Management System, 4(1), 40-44. doi: 10.18502/cbj.v4i1.16226
Hasan Haghaninejad; Seyed Ali Banifatemeh; Hamidreza Mohammadi; Seyed Kazem Razavi-Ratki; Reza Nafisi Moghadam; Nasim Namiranian; Ghazal Taheri Asl. "The role of serum uric acid in predicting left ventricular function and outcomes in patients with STEMI following PCI". Shahid Sadoughi University of Medical Sciences- Journal Management System, 4, 1, 2024, 40-44. doi: 10.18502/cbj.v4i1.16226
Haghaninejad, H., Banifatemeh, S., Mohammadi, H., Razavi-Ratki, S., Nafisi Moghadam, R., Namiranian, N., Taheri Asl, G. (2024). 'The role of serum uric acid in predicting left ventricular function and outcomes in patients with STEMI following PCI', Shahid Sadoughi University of Medical Sciences- Journal Management System, 4(1), pp. 40-44. doi: 10.18502/cbj.v4i1.16226
Haghaninejad, H., Banifatemeh, S., Mohammadi, H., Razavi-Ratki, S., Nafisi Moghadam, R., Namiranian, N., Taheri Asl, G. The role of serum uric acid in predicting left ventricular function and outcomes in patients with STEMI following PCI. Shahid Sadoughi University of Medical Sciences- Journal Management System, 2024; 4(1): 40-44. doi: 10.18502/cbj.v4i1.16226

The role of serum uric acid in predicting left ventricular function and outcomes in patients with STEMI following PCI

Cardiovascular Biomedicine
Volume 4, Issue 1, August 2024, Pages 40-44    PDF (298.89 K)
Document Type: original articles
DOI: 10.18502/cbj.v4i1.16226
Authors
Hasan Haghaninejad1; Seyed Ali Banifatemeh2; Hamidreza Mohammadi1; Seyed Kazem Razavi-Ratki3; Reza Nafisi Moghadam3; Nasim Namiranian4; Ghazal Taheri Asl* 1
1Yazd Cardiovascular Research Center, Non-communicable Diseases Research Institute, Shahid Sadoughi University of Medical Sciences, Yazd, Iran
2Department of Internal Medicine, Shahid Sadoughi University of Medical Sciences, Yazd, Iran
3Department of Radiology, Faculty of Medicine, Shahid Sadoughi University of Medical Sciences, Yazd, Iran
4Diabetes Research Center, Shahid Sadoughi University of Medical Sciences, Yazd, Iran
Abstract
Objectives: Percutaneous coronary intervention (PCI) is the preferred treatment for ST-elevation myocardial infarction (STEMI); however, reduced left ventricular ejection fraction (LVEF) remains a critical issue post-PCI. Serum uric acid (SUA) has emerged as a biomarker linked to cardiovascular events and may be associated with LVEF. This study aims to investigate the relationship between SUA levels and LVEF in STEMI patients treated with primary PCI and identify potential biomarkers for predicting patient outcomes.
 
Methods: This prospective study was conducted at Afshar Hospital, Shahid Sadoughi University of Medical Sciences of Yazd, from September 2019 to March 2021. Participants included 254 consecutive ST-elevation myocardial infarction (STEMI) patients undergoing primary PCI. Exclusion criteria were contraindications for angiography, history of myocardial infarction, PCI, CABG, NSTEMI, thrombolytic treatment, kidney diseases, gout, or alcoholism. Demographic data, clinical history, SUA levels, and echocardiographic parameters were collected. Statistical analysis was performed using SPSS version 20.0, with significance at p<0.05.
 
Results: 81.49% of patients were male, with a mean age of 57.7±11.47 years. Hypertension was the most prevalent condition (42.9%). SUA levels did not significantly differ between patients with LVEF below and above 40% (p=0.39). However, smoking was significantly associated with reduced LVEF (p<0.001). A weak negative correlation between SUA and LVEF was observed in males (p=0.012) but not in females (p=0.097). Overall, a weak negative correlation between SUA and LVEF was statistically significant (p=0.05).
 
Conclusions: Our findings revealed a weak but statistically significant overall negative correlation between SUA and EF. Further research with larger, more diverse populations is necessary to elucidate the relationship between SUA and cardiac function in STEMI patients.
Keywords
ST-elevation myocardial infarction; Serum uric acid; percutaneous coronary intervention
References
1.Thygesen K, Alpert JS, White HD, et al. Universal definition of myocardial infarction.Circulation. 2007;116(22):2634-53.

2.Tang N, Chen X, Li K, et al. Myocardial Perfusion in ST-Segment Elevation Myocardial Infarction Patients After Percutaneous Coronary Intervention: Influencing Factors and Intervention Strategies.Cureus. 2023;15(8):e42841.

3.Wang R, Mei B, Liao X, et al. Determination of risk factors affecting the in-hospital prognosis of patients with acute ST segment elevation myocardial infarction after percutaneous coronary intervention.BMC Cardiovasc Disord.2017;17(1):243.

4.Wu AH, Gladden JD, Ahmed M, et al. Relation of serum uric acid to cardiovascular disease. Int J Cardiol. 2016;213:4-7.

5.Nieto FJ, Iribarren C, Gross MD, et al. Uric acid and serum antioxidant capacity: a reaction to atherosclerosis?Atherosclerosis. 2000;148(1):131-9.

6.Cox P, Gupta S, Zhao S, et al. The incidence and prevalence of cardiovascular diseases in gout: a systematic review and meta-analysis. Rheumatol Int.2021;41(7): 1209-1219.

7.Strasak A, Ruttmann E, Brant L, et al. Serum Uric Acid and Risk of Cardiovascular Mortality: A Prospective Long-Term Study of 83 683 Austrian Men. Clin Chem.2008; 54(2):273-84.

8.Yan F, Zhang Y, Pan Y, et al. Prevalence and associated factors of mortality after percutaneous coronary intervention for adult patients with ST-elevation myocardial infarction:A systematic review and meta-analysis.J Res Med Sci. 2023;28:17.

9.Tanik VO, Cinar T, Arugaslan E, et al. The Predictive Value of PRECISE-DAPT Score for In-Hospital Mortality in Patients  With ST-Elevation Myocardial Infarction Undergoing Primary Percutaneous Coronary Intervention. Angiology.2019;70(5) :440-447.

10.Regitz-Zagrosek V, Gebhard C.Gender medicine: effects of sex and gender on cardiovascular disease manifestation and outcomes. Nat Rev Cardiol. 2023;20(4):236-247.

11.Feig DI, Kang DH, Johnson RJ. Uric acid and cardiovascular risk. N Engl J Med. 2008;359(17):1811-21.  

12.Yamamoto H, Nagatomo Y, Mahara K, et al. In-Hospital Serum Uric Acid Change Predicts Adverse Outcome in Patients With Heart Failure. J Card Fail.2020;26(11):968 -976.

13.Hsu PF, Chuang SY, Yu WC, et al. The Impacts of Serum Uric Acid on arterial hemodynamics and Cardiovascular Risks. Acta Cardiol Sin. 2013;29(2): 142-50.

14.Münzel T, Camici GG, Maack C, et al. Impact of Oxidative Stress on the Heart and Vasculature: Part 2 of a 3-Part Series. J Am Coll Cardiol.2017;70(2):212-229.

15.Ndrepepa G, Braun S, Haase HU, et al. Prognostic value of uric acid in patients with acute coronary syndromes. Am J Cardiol. 2012;109(9):1260-5.

16.Kojima S, Sakamoto T, Ishihara M, et al. Prognostic usefulness of serum uric acid after acute myocardial infarction (the Japanese Acute Coronary Syndrome Study). Am J Cardiol.2005; 96(4):489-95.

17.Kanbay M, Segal M, Afsar B, et al.The role of uric acid in the pathogenesis of human cardiovascular disease.Heart.2013;99(11):759-766.

Statistics
Article View: 142
PDF Download: 97


Journal Management System. Powered by Sinaweb