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Javaheri, A., Ekraminasab, S., Shams, S., Neamatzadeh, H. (2024). The Complex Relationship between Stress and Gestational Diabetes: Mechanisms and Interventions for Maternal and Fetal Health. Shahid Sadoughi University of Medical Sciences- Journal Management System, 7(1), 35-44. doi: 10.18502/wjpn.v7i1.17326
Atiyeh Javaheri; Sedigheh Ekraminasab; Seyedeh Elham Shams; Hossein Neamatzadeh. "The Complex Relationship between Stress and Gestational Diabetes: Mechanisms and Interventions for Maternal and Fetal Health". Shahid Sadoughi University of Medical Sciences- Journal Management System, 7, 1, 2024, 35-44. doi: 10.18502/wjpn.v7i1.17326
Javaheri, A., Ekraminasab, S., Shams, S., Neamatzadeh, H. (2024). 'The Complex Relationship between Stress and Gestational Diabetes: Mechanisms and Interventions for Maternal and Fetal Health', Shahid Sadoughi University of Medical Sciences- Journal Management System, 7(1), pp. 35-44. doi: 10.18502/wjpn.v7i1.17326
Javaheri, A., Ekraminasab, S., Shams, S., Neamatzadeh, H. The Complex Relationship between Stress and Gestational Diabetes: Mechanisms and Interventions for Maternal and Fetal Health. Shahid Sadoughi University of Medical Sciences- Journal Management System, 2024; 7(1): 35-44. doi: 10.18502/wjpn.v7i1.17326

The Complex Relationship between Stress and Gestational Diabetes: Mechanisms and Interventions for Maternal and Fetal Health

World Journal of Peri and Neonatology
Article 6, Volume 7, Issue 1, December 2024, Pages 35-44    PDF (505.03 K)
Document Type: Scientific Review
DOI: 10.18502/wjpn.v7i1.17326
Authors
Atiyeh Javaheri1; Sedigheh Ekraminasab* 2, 3; Seyedeh Elham Shams4; Hossein Neamatzadeh2
1Department of Obstetrics and Gynecology, School of Medicine, Shahid Sadoughi University of Medical Sciences, Yazd, Iran
2Mother and Newborn Health Research Center, Shahid Sadoughi University of Medical Sciences, Yazd, Iran
3Department of Hematology and Blood Banking, School of Allied Medical Sciences, Shahid Beheshti University of Medical Sciences, Tehran, Iran
4Department of Pediatrics, Hamadan University of Medical Sciences, Hamadan, Iran
Abstract
Gestational diabetes mellitus (GDM) is a prevalent complication during pregnancy that poses risks to both maternal and fetal health. This study aims to elucidate the intricate relationship between stress and the development of GDM, highlighting how stress-related hormonal fluctuations and behavioral changes—such as increased cortisol levels, inflammation, disrupted sleep patterns, and poor dietary choices—contribute to insulin resistance and glucose dysregulation. We examine the influence of stress on hormonal and lifestyle factors associated with GDM and evaluate interventions that manage stress-related metabolic disturbances. Elevated levels of stress hormones (like cortisol and adrenaline) and inflammatory markers (such as IL-6 and TNF-α) are linked to an increased risk of GDM due to their detrimental effects on insulin sensitivity. Our findings suggest that effective interventions, including mindfulness practices, cognitive-behavioral therapy, and regular physical activity, can reduce cortisol levels and enhance glucose regulation. This underscores the necessity of addressing both the metabolic and psychological dimensions of GDM. Current evidence supports the integration of stress-reduction strategies—such as mindfulness, cognitive-behavioral therapy, and exercise—into GDM management, as they can improve glycemic control by lowering cortisol and enhancing insulin sensitivity. Recognizing stress as a modifiable risk factor for GDM is crucial for improving maternal and fetal outcomes, emphasizing the importance of incorporating stress management into GDM prevention and treatment protocols.
Keywords
Gestational diabetes; Stress; Cortisol; Inflammation; Insulin resistance; Cognitive-behavioral therapy
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