Related Links
Statistics
| Number of Journals | 8 |
| Number of Issues | 59 |
| Number of Articles | 435 |
| Article View | 155,257 |
| PDF Download | 102,530 |
Incidence of major adverse cardiac and cerebrovascular events following primary percutaneous coronary intervention in central iran | ||
| Cardiovascular Biomedicine | ||
| Article 4, Volume 4, Issue 2, December 2024, Pages 22-29 PDF (576.14 K) | ||
| Document Type: original articles | ||
| DOI: 10.18502/cbj.v4i2.17791 | ||
| Authors | ||
| Abbas Andishmand* 1; Seyedeh Mahdieh Namayandeh2; Mehraban Ziafat1 | ||
| 1Yazd Cardiovascular Research Center, Non- communicable Diseases Research Institute, Shahid Sadoughi University of Medical Sciences, Yazd, Iran | ||
| 2Yazd Cardiovascular Research Center, Non- communicable Diseases Research Institute, Shahid Sadoughi University of Medical Sciences, Yazd, Iran | ||
| Abstract | ||
| Objectives: ST-segment elevation myocardial infarction (STEMI) is a critical form of acute coronary syndrome that requires immediate myocardial reperfusion to reduce infarct size and enhance patient outcomes. Despite improvements in the management of STEMI, it continues to be a global contributor to mortality. This study aimed to evaluate the long-term prognosis and outcomes of STEMI patients by investigating the incidence of major adverse cardiac and cerebrovascular events. (MACCE). Methods: This prospective cohort study enrolled 305 patients diagnosed with STEMI between March 2016 and February 2017 in Afshar Hospital, a tertiary cardiac hospital in central Iran. The researchers performed Primary percutaneous coronary intervention (PCI) using drug-eluting stents (DES), and patients received standard medical therapy. Data on major adverse cardiac and cerebrovascular events (MACCE), demographic characteristics, clinical factors, and procedural details were collected through patient interviews, medical records, and the myocardial infarction registry database. Results: The overall success rate of primary PCI was 92.8%. Hypertension was the most prevalent risk factor for coronary artery disease (41.1%). During the one-year follow-up, the incidence of MACCE was 15.1% (46 patients), with death being the most common occurring in 33 patients (10.8%). Mortality rates were highest within the first six months. The multivariate logistic regression analysis revealed that age (P=0.001) and stent length exceeding 30 mm (P=0.036) were significant predictors of mortality. Conclusions: This study provides important insights into primary PCI outcomes in STEMI patients in central Iran. The findings indicate a high success rate for PCI and emphasize the necessity for timely and appropriate management. MACCE incidence, especially mortality, highlights the importance of ongoing surveillance and comprehensive follow-up care. | ||
| Keywords | ||
| major adverse cardiac and cerebrovascular events (MACCE); myocardial infarction; primary percutaneous coronary intervention (PPCI); ST-elevation myocardial infarction (STEMI) | ||
| References | ||
|
1.Akbar H, Foth C, Kahloon RA, et al. Acute ST-Segment Elevation Myocardial Infarction(STMI). StatPearls[Internet]. 2024.
2.Ojha N, Dhamoon AS.Myocardial Infarction. StatPearls [Internet].2024.
3.Kaila KS, Bhagirath KM, Kass M, et al. Reperfusion times for ST elevation myocardial infarction: a prospective audit. Mcgill J Med.2007; 10(2):75-80.
4.Partow-Navid R, Prasitlumkum N, Mukherjee A, et al. Management of ST Elevation Myocardial Infarction (STEMI) in Different Settings. Int J Angiol. 2021; 30(1):67-75.
5.Bagai A, Dangas GD, Stone GW, et al. Reperfusion strategies in acute coronary syndromes. Circ Res. 2014 6; 114(12):1918-28.
6.Van de Werf F.The history of coronary reperfusion. Eur Heart J.2014; 35(37):2510-5.
7.Sanchis-Gomar F, Perez-Quilis C, Leischik R, et al. Epidemiology of coronary heart disease and acute coronary syndrome. Ann Transl Med. 2016; 4(13):256.
8.Goff DC Jr, Khan SS, Lloyd-Jones D, et al. Bending the Curve in Cardiovascular Disease Mortality: Bethesda + 40 and Beyond. Circulation.2021; 143(8):837-851.
9.Sachdeva P, Kaur K, Fatima S, et al. Advancements in Myocardial Infarction Management: Exploring Novel Approaches an Strategies.Cureus.2023;15(9):e45578.
10.Bayat S, Hashemi Nazari SS, Mehrabi Y, et al. Long-term Survival Rate Following Myocardial Infarction and the Effect of Discharge Medications on the Survival Rate. J Res Health Sci. 2022; 22(4):e00567.
11.Santos IS, Goulart AC, Brandão RM, et al. One-year Mortality after an Acute Coronary Event and its Clinical Predictors: The ERICO Study. Arq Bras Cardiol. 2015; 105(1):53-64.
12.Mozaffarian S, Etemad K, Aghaali M, et al. Short and Long-Term Survival Rates Following Myocardial Infarction and Its Predictive Factors: A Study Using National Registry Data. J Tehran Heart Cent. 2021; 16(2):68-74.
13.Chacko L, P Howard J, Rajkumar C, et al. Effects of Percutaneous Coronary Intervention on Death and Myocardial Infarction Stratified by Stable and Unstable Coronary Artery Disease: A Meta-Analysis of Randomized Controlled Trials. Circ Cardiovasc Qual Outcomes.2020; 13(2):e006363.
14.Polańska-Skrzypczyk M, Karcz M, Rużyłło W, et al.Successful primary percutaneous coronary intervention determines the very long-term prognosis in ST-segment elevation myocardial infarction even in survivors of the acute phase.The ANIN Myocardial Infarction Registry. Postepy Kardiol Interwencyjnej. 2019; 15(3):283-291.
15.Singh IM, Filby SJ, El Sakr F, et al. Drug-eluting stents versus bare-metal stents for treatment of bare-metal in-stent restenosis.Catheter Cardiovasc Interv. 2010;76(2): 257-62.
16.Wang C, Zhou L, Liang Y, et al. Interactions of ST-elevation myocardial infarction, age, and sex and the risk of major adverse cardiovascular events among Chinese adults: a secondary analysis of a single-centre prospective cohort. BMJ Open.2022; 12(7):e058494.
17.Millett ERC, Peters SAE, Woodward M. Sex differences in risk factors for myocardial infarction: cohort study of UK Biobank participants. BMJ.2018; 363:k4247.
18.Anand SS, Islam S, Rosengren A, et al. Risk factors for myocardial infarction in women and men: insights from the INTERHEART study. Eur Heart J.2008;29(7):932-40.
19.Nedkoff L, Briffa T, Murray K, et al. Risk of early recurrence and mortality in high-risk myocardial infarction patients: A population-based linked data study. Int J Cardiol Cardiovasc Risk Prev.2023;17: 200185.
20.Shah JA, Kumar R, Solangi BA, et al. One-year major adverse cardiovascular events among same-day discharged patients after primary percutaneous coronary intervention at a tertiary care cardiac centre in Karachi, Pakistan: a prospective observational study. BMJ Open.2023;13(4):e067971.
21.Yeh RW, Sidney S, Chandra M, et al. Population trends in the incidence and outcomes of acute myocardial infarction. N Engl J Med. 2010;362(23):2155-65.
22.Reed GW, Rossi JE, Cannon CP. Acute myocardial infarction. Lancet.2017;389 (10065):197-210.
23.Zimarino M, Ruggieri B, De Caterina R. Patient management and care after primary percutaneous coronary intervention: reinforcing a continuum of care after primary percutaneous coronary intervention. Am Heart J. 2010; 160(6 Suppl):S42-7. | ||
|
Statistics Article View: 150 PDF Download: 136 |
||