Related Links
Statistics
| Number of Journals | 8 |
| Number of Issues | 52 |
| Number of Articles | 384 |
| Article View | 119,696 |
| PDF Download | 87,868 |
The predictive significance of red cell distribution width in anterior ST- elevation myocardial infarction and its relationship with hospital mortality | ||
| Cardiovascular Biomedicine | ||
| Article 3, Volume 4, Issue 2, December 2024, Pages 14-21 PDF (510.2 K) | ||
| Document Type: original articles | ||
| DOI: 10.18502/cbj.v4i2.17790 | ||
| Authors | ||
| Haleh Bodagh1; Amin Ghanivash1; Shabnam Boudagh2; Mohammad bagher Bodagh3; Erfan Banisefid1; Arshiya Sakhaei4; Shima Mosadeghi Khiavi5; Razieh Parizad* 1 | ||
| 1Cardiovascular Research Center, Tabriz University of Medical Sciences, Tabriz, Iran | ||
| 2Echocardiography Research Center, Rajaie Cardiovascular Institute, Tehran, Iran | ||
| 3Faculty of Medicine, Tabriz Medical Sciences, Islamic Azad University, Tabriz, Iran | ||
| 4School of Medicine, Kermanshah University of Medical Sciences, Kermanshah, Iran | ||
| 5Student Research Committee, Tabriz University of Medical Sciences, Tabriz, Iran | ||
| Abstract | ||
| Objectives: The clinical diagnosis of acute myocardial infarction (AMI) involves assessing the patient's medical history and indirect evidence of myocardial necrosis using biochemical, electrocardiogram (ECG), or imaging methods. Ischemia, hypoxia, and myocardial necrosis result from a disrupted blood supply to the coronary arteries, typically due to atherosclerosis, thrombosis, and coronary artery obstruction. Given the rising incidence and healthcare costs of ST-elevation myocardial infarction (STEMI), particularly anterior STEMI (ant-STEMI), this study examines the diagnostic value of red cell distribution width (RDW) in ant-STEMI patients and its impact on hospital and one-year mortality post-primary angioplasty. Methods: This study focused on patients with ant-STEMI undergoing primary angioplasty at Shahid Madani Hospital, Tabriz, Iran, from 2018 to 2019. Exclusion criteria included patients receiving drug or antithrombotic treatment, undergoing coronary artery bypass grafting (CABG), not receiving primary percutaneous coronary intervention (PPCI), suffering from STEMI types other than anterior STEMI, having a history of thalassemia or anemia, and those with incomplete patient records. In-hospital complications, such as cardiogenic shock, hematoma, bleeding, and heart failure (HF), were recorded and analyzed using SPSS 23. Results: In this retrospective and analytical study of 300 patients, there was no significant relationship between RDW levels and in-hospital (P-value=0.59) and one-year mortality (P-value=0.68). However, RDW was significantly associated with hospital complications such as HF, cardiogenic shock, angio-hematoma, gastrointestinal bleeding, and stent thrombosis (P-value<0.01). Conclusions: Our study showed that RDW is not a reliable prognostic factor for mortality in anterior STEMI patients. | ||
| Keywords | ||
| Acute myocardial infarction; Red cell distribution width; Hospital mortality | ||
| References | ||
|
1.Kushner FG, Hand M, Smith SC, et al. 2009 focused updates: ACC/AHA guidelines for the management of patients with ST-elevation myocardial infarction (updating the 2004 guideline and 2007 focused update) and ACC/AHA/SCAI guidelines on percutaneous coronary intervention (updating the 2005 guideline and 2007 focused update) a report of the American College of Cardiology Foundation/American Heart Association Task Force on Practice Guidelines. J Am Coll Cardiol.2009;54(23):2205-41.
2.Barefoot JC, Schroll M. Symptoms of depression, acute myocardial infarction, and total mortality in a community sample.Circulation.1996;93(11):1976-80.
3.The effects of tissue plasminogen activator, streptokinase, or both on coronary-artery patency, ventricular function, and survival after acute myocardial infarction.N Engl J Med. 1993;329(22):1615-22.
4.Stone GW, Witzenbichler B, Guagliumi G, et al.Bivalirudin during primary PCI in acute myocardial infarction. N Engl J Med.2008;358(21):2218-30.
5.Keeley EC, Boura JA, Grines CL.Primary angioplasty versus intravenous thrombolytic therapy for acute myocardial infarction: a quantitative review of 23 randomised trials. Lancet.2003;361(9351):13-20.
6.Patel KV, Ferrucci L, Ershler WB, et al. Red blood cell distribution width and the risk of death in middle-aged and older adults. Arch Intern Med. 2009;169(5):515-23.
7.García-Escobar A, Lázaro-García R, Goicolea-Ruigómez J, et al. Red Blood Cell Distribution Width is a Biomarker of Red Cell Dysfunction Associated with High Systemic Inflammation and a Prognostic Marker in Heart Failure and Cardiovascular Disease: A Potential Predictor of Atrial Fibrillation Recurrence. High Blood Press Cardiovasc Prev. 2024;31(5):437-449.
8.Ikuta KS, Swetschinski LR, Aguilar GR, et al. Global mortality associated with 33 bacterial pathogens in 2019: a systematic analysis for the Global Burden of Disease Study 2019. Lancet.2022;400(10369): 2221-2248.
9.Fava C,Cattazzo F,Hu Z-D,et al.The role of red blood cell distribution width (RDW) in cardiovascular risk assessment: useful or hype? Ann Transl Med. 2019;7(20):581.
10.Saad H, Soliman HA, Mahmoud B, et al. The pathogenic role of oxidative stress, cytokine expression, and impaired hematological indices in diabetic cardiovascular diseases. Inflammation. 2023;46(1):146-160.
11.Tunçez A, Çetin MS, Çetin E, et al. Association between RDW and stent thrombosis in patients with ST-elevation myocardial infarction undergoing primary percutaneous coronary intervention.Medicine (Baltimore).2017;96(5):e5986.
12.Poludasu S, Marmur JD, Weedon J, et al.Red cell distribution width (RDW) as a predictor of long-term mortality in patients undergoing percutaneous coronary intervention.Thromb Haemost. 2009;102(3):581-7.
13.Marković Boras M, Brizić I, Mikulić I.The significance of red cell distribution width and homocysteine values in STEMI patients undergoing PCI in the population of Bosnia and Herzegovina.Eur Rev Med Pharmacol Sci.2021;25(10):3791-3797.
14.Karakas MS, Korucuk N, Tosun V, et al. Red cell distribution width and neutrophil-to-lymphocyte ratio predict left ventricular dysfunction in acute anterior ST-segment elevation myocardial infarction. J Saudi Heart Assoc.2016;28(3):152 -8.
15.Ming L, Cao H-l, Li Q, et al. Red blood cell distribution width as a predictive marker for coronary artery lesions in patients with kawasaki disease. Pediatr Cardiol. 2021;42(7):1496-1503.
16.Jian W, Shen X, Zheng Z, et al. Association between red blood cell distribution width and coronary calcification in patients referred for invasive coronary angiography. Angiology.2024:33197241238509.
17.Uyarel H, Ergelen M, Cicek G, et al.Red cell distribution width as a novel prognostic marker in patients undergoing primary angioplasty for acute myocardial infarction.Coron Artery Dis. 2011;22(3):138-44.
18.Chang XW, Zhang SY, Wang H, et al. Combined value of red blood cell distribution width and global registry of acute coronary events risk score on predicting long-term major adverse cardiac events in STEMI patients undergoing primary PCI. Oncotarget. 2018;9(17):13971-13980.
19.Akboga MK, Yayla C, Yilmaz S, et al. Increased red cell distribution width predicts occlusion of the infarct-related artery in STEMI.Scand Cardiovasc J.2016;50(2):114-8.
20.Osadnik T, Strzelczyk J, Hawranek M, et al.Red cell distribution width is associated with long-term prognosis in patients with stable coronary artery disease. BMC Cardiovasc Disord. 2013;13:113.
21.Liu XM, Ma CS, Liu XH, et al. Relationship between red blood cell distribution width and intermediate-term mortality in elderly patients after percutaneous coronary intervention. J Geriatr Cardiol.2015;12(1):17-22.
22.Khaki S, Mortazavi SH, Bozorgi A, et al. Relationship Between Red Blood Cell Distribution Width and Mortality of Patients with Acute Myocardial Infarction Referring to Tehran Heart Center.Crit Pathw Cardiol.2015;14(3):112-5.
23.Sun XP, Chen WM, Sun ZJ, et al. Impact of red blood cell distribution width on long-term mortality in patients with ST-elevation myocardial infarction.Cardiology.2014;128(4):343-8.
24.Arbel Y, Shacham Y, Finkelstein A, et al. Red blood cell distribution width (RDW) and long-term survival in patients with ST elevation myocardial infarction.Thromb Res. 2014;134(5):976-9.
25.Lippi G, Turcato G, Cervellin G, et al. Red blood cell distribution width in heart failure: A narrative review.World J Cardiol. 2018;10(2):6-14.
26.Cole J, Ertoy D, Lin H, et al. Lack of angiotensin II-facilitated erythropoiesis causes anemia in angiotensin-converting enzyme-deficient mice. J Clin Invest.2000;106(11): 1391-8.
27.Prondzinsky R, Unverzagt S, Lemm H, et al. Interleukin-6, -7, -8 and -10 predict outcome in acute myocardial infarction complicated by cardiogenic shock. Clin Res Cardiol.2012;101(5):375-84.
28.Pierce CN, Larson DF. Inflammatory cytokine inhibition of erythropoiesis in patients implanted with a mechanical circulatory assist device. Perfusion.2005;20(2):83-90.
29.He Y, Liu C, Zeng Z, et al. Red blood cell distribution width: a potential laboratory parameter for monitoring inflammation in rheumatoid arthritis.Clin Rheumatol.2018; 37(1):161-167.
30.Liao Y, Zhang R, Shi S, et al. Red blood cell distribution width predicts gastrointestinal bleeding after coronary artery bypass grafting.BMC Cardiovasc Disord.2022;22(1):436.
31.Gurbuz O, Kumtepe G, Ozkan H, et al. Red blood cell distribution width predicts long term cardiovascular event after on-pump beating coronary artery bypass grafting. J Cardiothorac Surg. 2016;11:48.
32.Allen LA, Felker GM, Mehra MR, et al.Validation and potential mechanisms of red cell distribution width as a prognostic marker in heart failure. J Card Fail.2010;16(3): 230-8.
33.Li N, Zhou H, Tang Q. Red Blood Cell Distribution Width: A Novel Predictive Indicator for Cardiovascular and Cerebrovascular Diseases. Dis Markers.2017;2017: 7089493. | ||
|
Statistics Article View: 127 PDF Download: 126 |
||