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A Mini Review on Testicular Tissue Engineering: A Roadmap for Future Research | ||
| Regenerative Biomedicine | ||
| Volume 1, Issue 3, July 2025, Pages 229-234 PDF (664.53 K) | ||
| Document Type: Mini-Review | ||
| DOI: 10.22034/jrb.2025.546.1026 | ||
| Authors | ||
| Mahin Izadi* 1; Serajoddin Vahidi Vahidi1; Mohammad Ebrahim Rezvani2 | ||
| 1Research and Clinical Center for Infertility, Yazd Reproductive Sciences Institute, Shahid Sadoughi University of medical sciences, Yazd, Iran | ||
| 2Department of Physiology, School of Medicine, Shahid Sadoughi University of Medical Sciences and Health Services, Yazd, Iran | ||
| Abstract | ||
| Testicular tissue engineering (TTE) is an emerging interdisciplinary field combining principles of regenerative medicine, biomaterials, and stem cell therapy to address male infertility caused by testicular dysfunction. The aim of this study is to investigate recent advancements, challenges, and future directions in TTE, focusing on scaffold-based approaches, stem cell therapies, and 3D culture systems, by integrating recent studies, up to December 2024 in databases including PubMed, Scopus, and Web of Science. Search terms included “testicular tissue engineering,” “male infertility,” “spermatogenesis,” “scaffolds,” and “stem cell therapy.” Present study highlights novel strategies, such as 3D bioprinting and decellularized testicular matrices, and justifies their originality in overcoming limitations of traditional fertility preservation methods. By integrating findings from diverse academic sources, and an overview of TTE’s potential to revolutionize male reproductive health, while identifying critical areas for current theoretical gaps and future research. | ||
| Keywords | ||
| Infertility; Regenerative medicine; Scaffolds; Testicular tissue engineering; 3D culture | ||
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