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Exosome therapy for Cancer Treatment: Drug Delivery Tools | ||
| Advances in Pharmacology and Therapeutics Journal | ||
| Articles in Press, Accepted Manuscript, Available Online from 08 September 2025 | ||
| Document Type: Review Article | ||
| Authors | ||
| Seyed Hossein Khaleghinejad1; Marzieh Lotfi2; Seyed Hossein Shahcheraghi* 3 | ||
| 1Faculty of Biotechnology, Amol University of Special Modern Technologies, Amol, Iran | ||
| 2Abortion Research Center, Reproductive Sciences Institute, Shahid Sadoughi University of Medical Sciences, Yazd, Iran | ||
| 3Reproductive Immunology Research Center, Shahid Sadoughi University of Medical Sciences, Yazd, Iran | ||
| Abstract | ||
| Exosomes are vesicles that naturally transport molecules between cells and have emerged as promising systems for cancer therapy. Exosomes have a lipid bilayer membrane on their surface that contains glycoproteins, tetraspanins, and receptors. Inside the exosomes, there is DNA and micro RNA (miRNA) enclosed. Due to their ability to deliver drugs, proteins, and microRNAs (miRNA), they offer a selective, stable alternative to traditional cancer treatments, which often have severe side effects. Exosomes can be engineered to target cancer cells more effectively, reducing tumor growth and enhancing immune responses. The method for isolating them is broken down into three main parts: (1) initial steps before isolation that involve obtaining fluids containing exosomes, focusing on protocols for organ explants and cell cultures; (2) The actual process of exosome isolation, which includes various gradient options; and (3) procedures conducted after isolation to assess the purity and quantity of the exosomal fraction. However, challenges like production efficiency and standardization still need to be overcome. Artificial exosomes, which combine the benefits of natural and synthetic systems, are being developed to meet these needs. Future research could focus on optimizing exosome engineering techniques and exploring their applications in various cancer therapies. | ||
| Keywords | ||
| Exosome; Drug delivery; cancer therapy | ||
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