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Effects of L- Carnitine Supplementation on Nitric Oxide Concentration in Pemphigus Vulgaris Patients: A Double-Blind Randomized Clinical Trial | ||
| Advances in Pharmacology and Therapeutics Journal | ||
| Articles in Press, Accepted Manuscript, Available Online from 08 September 2025 | ||
| Document Type: Original Article | ||
| Authors | ||
| zahra fakhri* 1; hamed mohammadi2; farnaz sepandar3; elham yaghobi3; Mohammad Hassan Javanbakht3 | ||
| 11. Instructor of Nutritional Sciences, School of Medical Sciences, Khalkhal Faculty of Medical Sciences, khalkhal, Iran. Email: z.f.fakhri@gmail.com, z.fakhry@khalums.ac.ir. ORCID ID: 0000-0002-8044-2233. | ||
| 2Assistant Professor of Nutritional Sciences Department of Clinical Nutrition, School of Nutritional Sciences & Dietetics Shariati Hospital Tehran University of Medical Sciences | ||
| 32. Department of Cellular and Molecular Nutrition, School of Nutritional Sciences and Dietetics, Tehran University of Medical Sciences, Tehran, Iran. | ||
| Abstract | ||
| ABSTRACT Background and objective: Blisters on the human skin and mucous membranes are an indicator of the extremely uncommon autoimmune disease known as Pemphigus vulgaris (PV). Elevated levels of reactive oxygen species (ROS) are linked to this condition. Nitric oxide (NO), produced by endothelial cells, is a key signaling molecule that contributes to vascular function and can act as an antioxidant by neutralizing reactive oxygen species in certain biological contexts. A substance that resembles a vitamin, L-carnitine, positively influences antioxidant levels. This study sought to determine the effects of L-carnitine supplementation on serum level of nitric oxide in Pemphigus vulgaris patients. Method and material: This clinical trial included a total of 46 patients with Pemphigus Vulgaris, aged between 30 and 65. Participants were randomly divided into two groups: one receiving L-Carnitine (n = 23) and the other a placebo (n = 23). Each group took either 2000 mg of L-Carnitine or placebo tablets daily. The intervention was conducted over an 8-week period, with serum L-Carnitine and nitric oxide (NO) levels assessed both pre- and post-intervention. Results: At baseline, in the intervention and control groups; Age, weight, height, and BMI (p > 0.05) did not differ statistically significant. By the end of the study, patients in the L-Carnitine group showed a significant increase in serum L-Carnitine levels (from 74.56±36.36 to 97.49±41.27, p<0.001) and in nitric oxide (NO) concentration (from 202.37±14.59 to 242.98±20.63, p=0.006) In contrast, the placebo group did not show any significant changes in either parameter (p>0.05). Conclusion: Daily consumption of 2 g of L-Carnitine for 8 weeks in patients with PV has positive effects on reducing oxidative stress and increasing serum nitric oxide levels. Keywords: Pemphigus vulgaris, L-carnitine, Nitric oxide, Antioxidant, Oxidative stress | ||
| Keywords | ||
| Pemphigus vulgaris; L-carnitine; Nitric oxide; Antioxidant; Oxidative stress | ||
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