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Clinicopathological Features of Fungal Infections in COVID-19 Patients: A retrospective study in Yazd, Iran | ||
| Advances in Pharmacology and Therapeutics Journal | ||
| Articles in Press, Accepted Manuscript, Available Online from 08 September 2025 | ||
| Document Type: Original Article | ||
| Authors | ||
| marayam vajihinejad* 1; Faezesadat Heidari2; mohammad ali aghaei3; ali sartipzadeh4 | ||
| 1Department of Pathology, School of Medicine , Shahid Sadoughi University of Medical Sciences, Yazd, Iran | ||
| 2Department of Infectious Disease, School of Medicine, Infectious Disease Research Center, Shahid Sadoughi University of Medical Sciences, Yazd, Iran | ||
| 3Department of Otolaryngology-Head and Neck Surgery, Shahid Sadoughi University of Medical Sciences, Yazd, Iran. | ||
| 4Medical Doctor, Shahid Sadoughi University of Medical Sciences, Yazd, Iran. | ||
| Abstract | ||
| Introduction: Patients with COVID-19 due to unspecified medical treatment, hospitalization in the intensive care unit, need for invasive or non-invasive ventilation, prescription of broad-spectrum antibiotics, use of corticosteroids, and suffering from other underlying diseases, especially diabetes, are opportunistic to fungal infection. This study investigated the clinicopathology of fungal infections in patients with COVID-19 in samples sent to the pathology department of Shahid Sadoughi Hospital in Yazd, Iran from 2020 to 2022. Methods: This is an analytical cross-sectional. The information related to patients with COVID-19 and fungal infections who were referred to the pathology department of Shahid Sadoughi Hospital in Yazd, Iran from March 2020 to March 2022 was analyzed. Age, gender, clinical manifestations, type of fungal infection, site of involvement, mortality, duration of hospitalization and hospitalization department, need for mechanical ventilation, and clinical symptoms were extracted from patients’ files and recorded in a researcher-made questionnaire. The data were statistically analyzed using SPSS version 26. Results: In this study, fungal infections were confirmed in 53 patients with COVID-19 based on pathological diagnosis. Among them, 30 (56.6%) were men and 23 (43.4%) were women. The average age of the patients was 54.26 ± 18.07 years. In the pathological examination of fungal samples, 50 (94.3%) cases of mucormycosis, 2 (3.8%) cases of Aspergillus, and 1 (1.9%) case of simultaneous mucormycosis and Aspergillus were reported. Fungal infections involved the nasal cavity in 31 (58.5%) cases and paranasal sinuses in 18 (34%) cases. After the treatment period, the patients were discharged, and 14 (26.4%) patients died. Conclusion: we concluded that fungal infections following COVID-19 infection are associated with serious complications and have a high mortality rate; therefore, it is recommended that patients who are liable to suffer from fungal infections should avoid over-treatment and treat them more carefully for COVID-19 to prevent possible fungal infection. | ||
| Keywords | ||
| COVID-19; fungus infection; mucormycosis | ||
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