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Drugs Prescribing Pattern Among Patients with Cancer in Yazd, Iran (2021): A Cross-Sectional Study | ||
| Advances in Pharmacology and Therapeutics Journal | ||
| Articles in Press, Accepted Manuscript, Available Online from 08 September 2025 | ||
| Document Type: Original Article | ||
| Authors | ||
| Golnaz Afzal1; Eftekhar Morabbi* 2; Mohsen Nabi Meybidi3 | ||
| 1Department of Clinical Pharmacy, School of Pharmacy, Shahid Sadoughi University of Medical Sciences and Health Services, Yazd, Iran. | ||
| 2Department of Clinical Pharmacy, School of Pharmacy, Shahid Sadoughi University of Medical Sciences and Health Services, Yazd, Iran | ||
| 3Department of Pharmaceutics, Faculty of Pharmacy, Shahid Sadoughi University of Medical Sciences, Yazd, Iran. | ||
| Abstract | ||
| Abstract Background: Evaluating chemotherapy prescription patterns is crucial due to the increasing use of nutritional supplements, and adjuvant alongside chemotherapy, leading to heightened drug interactions and side effects. Aim: This study aimed to assess chemotherapy prescription patterns,nutritional supplements, and adjuvant of patients with cancer in Yazd, Iran. Method: This cross-sectional study was performed on the prescriptions of all cancer patients referred to Shahid Chamran Teaching Pharmacy, affiliated to the Faculty of Pharmacy, Shahid Sadouqi University of Medical Sciences, Yazd, Iran from September to October in 2021. prescribed chemotherapy drugs, generic chemotherapy drugs, essential drug list (EDL) chemotherapy drugs, and injectable chemotherapy drugs and supplement types in each prescription were recorded. SPSS Version 22 and various statistical tests were employed for analysis. Results: On average, each prescription included 2.37 ± 1.22 prescribed chemotherapy drugs, 1.89 ± 1.28 chemotherapy drugs by generic name, 2.21 ± 1.29 chemotherapy drugs from EDL, and 1.99±1.39 injectable chemotherapy drugs. Monotherapy accounted for 29.4% of prescriptions, with the remainder being combination chemotherapy. Oral drugs comprised 10.8%, while the rest were injectables. Cyclophosphamide had the highest frequency among chemotherapy drugs, while alkylating agents dominated. Dexamethasone and granisteron were the most common adjuvants, while Granisetron is not in the Iran Essential Medicine List. Major polypharmacy prevalence was significant (P-value = 0.001). Conclusions: The average prescription included a significant number of drugs compared to international standards, with over half exhibiting major polypharmacy. Despite American guidelines discouraging supplement use, 20% of prescriptions included dietary supplements. Key terms: Chemotherapy, Drug prescription, Drug supplement, Polypharmacy | ||
| Keywords | ||
| Chemotherapy; Drug prescription; Drug supplement; Polypharmacy | ||
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