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From Liraglutide to Tirzepatide: New Frontiers in Anti-Obesity Pharmacotherapy | ||
| Advances in Pharmacology and Therapeutics Journal | ||
| Articles in Press, Accepted Manuscript, Available Online from 29 September 2025 PDF (394.67 K) | ||
| Document Type: Editorial Article | ||
| Author | ||
| Mohsen Zabihi* | ||
| Department of Pharmacology, Faculty of Pharmacy, Shahid Sadoughi University of Medical Sciences and Health services, Yazd, Iran | ||
| Abstract | ||
| Obesity is a global health challenge, with over one billion people affected worldwide. While lifestyle changes remain essential, pharmacological interventions have become increasingly crucial in managing this complex condition. This editorial explores the evolution of anti-obesity medications, from liraglutide to the more recent breakthroughs like semaglutide and tirzepatide. These drugs, especially the newer GLP-1 and dual GIP/GLP-1 receptor agonists, have shown remarkable efficacy—comparable to bariatric surgery in some cases. The discussion highlights not only their clinical benefits but also their mechanisms, limitations, and future potential. As science advances, the integration of these therapies into mainstream care could significantly transform obesity treatment and improve long-term health outcomes. | ||
| Keywords | ||
| Liraglutide; Tirzepatide; Obesity; GLP-1 Agonists; GIP Agonists; incretin | ||
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