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Zare-Ahmadabadi, A., Shajari, A., Karimi, M., Shamsi, F. (2025). Kidney function in hospitalized children (<18 years) with COVID-19 at Shahid Sadoughi Hospital, Yazd (2019-2020). Shahid Sadoughi University of Medical Sciences- Journal Management System, (), -.
Atefeh Zare-Ahmadabadi; Ahmad Shajari; Mehran Karimi; Farimah Shamsi. "Kidney function in hospitalized children (<18 years) with COVID-19 at Shahid Sadoughi Hospital, Yazd (2019-2020)". Shahid Sadoughi University of Medical Sciences- Journal Management System, , , 2025, -.
Zare-Ahmadabadi, A., Shajari, A., Karimi, M., Shamsi, F. (2025). 'Kidney function in hospitalized children (<18 years) with COVID-19 at Shahid Sadoughi Hospital, Yazd (2019-2020)', Shahid Sadoughi University of Medical Sciences- Journal Management System, (), pp. -.
Zare-Ahmadabadi, A., Shajari, A., Karimi, M., Shamsi, F. Kidney function in hospitalized children (<18 years) with COVID-19 at Shahid Sadoughi Hospital, Yazd (2019-2020). Shahid Sadoughi University of Medical Sciences- Journal Management System, 2025; (): -.

Kidney function in hospitalized children (<18 years) with COVID-19 at Shahid Sadoughi Hospital, Yazd (2019-2020)

World Journal of Peri & Neonatology
Articles in Press, Accepted Manuscript, Available Online from 12 November 2025
Document Type: Original Article
Authors
Atefeh Zare-Ahmadabadi1; Ahmad Shajari1; Mehran Karimi* 2; Farimah Shamsi3
1School of Medicine, Yazd Branch, Islamic Azad University, Yazd, Iran
2Children Growth Disorder Research Center, Shahid Sadoughi University of Medical Sciences, Yazd, Iran
3Department of Biostatistics and Epidemiology, School of Public Health, Shahid Sadoughi University of Medical Sciences, Yazd, Iran
Abstract
Background: Acute kidney injury (AKI) is a concerning complication in pediatric COVID-19. This study aimed to evaluate kidney function in hospitalized children with COVID-19 in Yazd, Iran.
Methods: This cross-sectional study retrospectively analyzed data from children (<18 years) hospitalized with COVID-19 at Shahid Sadoughi Hospital in 2019-2020. Data on demographics, clinical symptoms, laboratory results (including serum creatinine, BUN, and urinalysis), and outcomes were collected.
Results: In a cohort of 155 patients, the mean creatinine level was 0.84 mg/dL (SD=1.2). Children≤ 3 years had a mean creatinine of 0.95 mg/dL (SD = 1.51), while those> 3-18 years had 0.74 mg/dL (SD = 0.84). Overall, 16.77% (n=26) showed abnormal creatinine based on age-adjusted ranges. Creatinine levels were significantly associated with disease severity (p = 0.002); a greater proportion of severe/critical COVID-19 patients had normal creatinine. Most patients had negative proteinuria (96.3%, n = 184). Hematuria and leukocyturia were present in 33.93% and 88.23% of tested patients, respectively. Among those with BUN data, 67% (n = 70) had BUN>18. Survival was lower in patients with preexisting kidney disease (71.4%) versus those without (91.4%), but this difference was not statistically significant (p = 0.085).
Conclusions: Kidney dysfunction was observed in a subset of hospitalized children with COVID-19. Abnormal creatinine was associated with non-severe disease. Preexisting kidney disease was associated with poorer outcomes, although not statistically significant.
Keywords
COVID-19; children; kidney function; AKI; creatinine; Iran
References
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