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Moghimi-Moghadam, S., Cheraghinik, A., Ahmadnia, Z., Hoseini, S., Montazeri, F. (2025). Multi-Tissue ceRNA Network Elucidates Exosome-Mediated Pathogenesis of Premature Ovarian Insufficiency with Implications for the Stem Cell Niche. Shahid Sadoughi University of Medical Sciences- Journal Management System, 1(4), 250-266. doi: 10.22034/jrb.2025.12.V1I4A1
Seyedeh Mahdieh Moghimi-Moghadam; Amirreza Cheraghinik; Zahra Ahmadnia; Seyed Mehdi Hoseini; Fateme Montazeri. "Multi-Tissue ceRNA Network Elucidates Exosome-Mediated Pathogenesis of Premature Ovarian Insufficiency with Implications for the Stem Cell Niche". Shahid Sadoughi University of Medical Sciences- Journal Management System, 1, 4, 2025, 250-266. doi: 10.22034/jrb.2025.12.V1I4A1
Moghimi-Moghadam, S., Cheraghinik, A., Ahmadnia, Z., Hoseini, S., Montazeri, F. (2025). 'Multi-Tissue ceRNA Network Elucidates Exosome-Mediated Pathogenesis of Premature Ovarian Insufficiency with Implications for the Stem Cell Niche', Shahid Sadoughi University of Medical Sciences- Journal Management System, 1(4), pp. 250-266. doi: 10.22034/jrb.2025.12.V1I4A1
Moghimi-Moghadam, S., Cheraghinik, A., Ahmadnia, Z., Hoseini, S., Montazeri, F. Multi-Tissue ceRNA Network Elucidates Exosome-Mediated Pathogenesis of Premature Ovarian Insufficiency with Implications for the Stem Cell Niche. Shahid Sadoughi University of Medical Sciences- Journal Management System, 2025; 1(4): 250-266. doi: 10.22034/jrb.2025.12.V1I4A1

Multi-Tissue ceRNA Network Elucidates Exosome-Mediated Pathogenesis of Premature Ovarian Insufficiency with Implications for the Stem Cell Niche

Regenerative Biomedicine
Volume 1, Issue 4, December 2025, Pages 250-266    PDF (2.43 M)
Document Type: Original Article
DOI: 10.22034/jrb.2025.12.V1I4A1
Authors
Seyedeh Mahdieh Moghimi-Moghadam1, 2; Amirreza Cheraghinik1; Zahra Ahmadnia1; Seyed Mehdi Hoseini3, 4; Fateme Montazeri* 5
1Abortion Research Center, Yazd Reproductive Sciences Institute, Shahid Sadoughi University of Medical Sciences, Yazd, Iran
2Department of Biology, Yazd University, Yazd, Iran
3Hematology and Oncology Research Center, Non-communicable Diseases Research Institute, Shahid Sadoughi University of Medical Sciences, Yazd, Iran
4Biotechnology Research Center, Yazd Reproductive Sciences Institute, Shahid Sadoughi University of Medical Sciences, Yazd, Iran
5Abortion Research Center, Yazd Reproductive Sciences Institute, Shahid Sadoughi University of Medical Sciences and Health Services, Yazd, Iran
Abstract
Premature Ovarian Insufficiency (POI) remains a significant cause of female infertility, yet its molecular mechanisms are incompletely understood. This study employed an integrative bioinformatics approach using multiple GEO datasets to construct a comprehensive ceRNA network across granulosa cells, cumulus cells, and exosomal miRNAs in POI. We identified distinct molecular signatures: granulosa cells showed cell cycle disruption, while cumulus cells exhibited differentiation pathway dysregulation. The core ceRNA network revealed 4 lncRNAs potentially regulating 31 mRNAs through sponging 4 key miRNAs (miR-423-5p, miR-106b-5p, miR-452-5p, and miR-3613-5p). Functional enrichment of these mRNAs implicated key stem cell-related pathways, including pluripotency and Hippo signaling. These findings provide novel insights into POI pathogenesis through exosome-mediated regulatory mechanisms, suggesting potential therapeutic targets for ovarian dysfunction and highlighting specific implications for the ovarian stem cell niche.
Keywords
Bioinformatics Analysis; ceRNA Network; Exosomal miRNAs; Premature Ovarian Insufficiency (POI); Stem Cell Niche
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