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Tissue Engineering Approaches for Restoring Ovarian Function in Premature Ovarian Insufficiency: Current Advances and Future Perspectives | ||
| Regenerative Biomedicine | ||
| Volume 1, Issue 4, December 2025, Pages 303-332 PDF (1.12 M) | ||
| Document Type: Review Article | ||
| DOI: 10.22034/jrb.2025.12.V1I4A5 | ||
| Author | ||
| Fatemeh Kuchakzade* | ||
| Biotechnology Research Center, Yazd Reproductive Sciences Institute, Shahid Sadoughi University of Medical Sciences, Yazd, Iran | ||
| Abstract | ||
| POI is a complex disorder characterized by the loss of normal ovarian function before the age of 40, profoundly affecting fertility, hormonal regulation, and overall quality of life. Current therapeutic approaches, including hormone replacement therapy and oocyte donation, primarily manage symptoms and are unable to restore the physiological function of the ovaries. Despite notable advancements, several challenges remain, such as ensuring the long-term safety of cell transplantation, achieving precise control over stem cell differentiation, and minimizing the potential risk of malignancies. Tissue engineering, as a rapidly evolving field in regenerative medicine, offers a promising strategy to overcome these limitations. By integrating stem cells, biomaterial scaffolds, and growth factors, tissue engineering aims to reconstruct the natural architecture and function of ovarian tissue. This approach holds potential for addressing hormonal imbalances, metabolic disturbances, and infertility issues caused by POI. This review examines the latest progress in ovarian tissue engineering, highlighting the roles of different components in ovarian regeneration and discussing remaining technical and clinical challenges. By providing a comprehensive overview, this work emphasizes the potential of tissue engineering to form the basis for future regenerative therapies, ultimately improving reproductive health and enhancing the quality of life for women affected by POI. | ||
| Keywords | ||
| Biomaterial scaffolds; Growth factors; Premature ovarian insufficiency (POI); Stem cells; Tissue engineering | ||
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