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Vahedi-Zarch, H., Lookzadeh, M., Noorishadkam, M., Mirjalili, S., Gholami Banadkoki, M., Shamsi, F. (2025). Evaluation of the Effect of Inhaled Salbutamol in the Treatment of Neonates with a Diagnosis of TTN. Shahid Sadoughi University of Medical Sciences- Journal Management System, 7(2), 64-71. doi: 10.18502/wjpn.v7i2.20447
Hasan Vahedi-Zarch; Mohamad Hosein Lookzadeh; Mahmood Noorishadkam; Seyed Reza Mirjalili; Mohammadreza Gholami Banadkoki; Farimah Shamsi. "Evaluation of the Effect of Inhaled Salbutamol in the Treatment of Neonates with a Diagnosis of TTN". Shahid Sadoughi University of Medical Sciences- Journal Management System, 7, 2, 2025, 64-71. doi: 10.18502/wjpn.v7i2.20447
Vahedi-Zarch, H., Lookzadeh, M., Noorishadkam, M., Mirjalili, S., Gholami Banadkoki, M., Shamsi, F. (2025). 'Evaluation of the Effect of Inhaled Salbutamol in the Treatment of Neonates with a Diagnosis of TTN', Shahid Sadoughi University of Medical Sciences- Journal Management System, 7(2), pp. 64-71. doi: 10.18502/wjpn.v7i2.20447
Vahedi-Zarch, H., Lookzadeh, M., Noorishadkam, M., Mirjalili, S., Gholami Banadkoki, M., Shamsi, F. Evaluation of the Effect of Inhaled Salbutamol in the Treatment of Neonates with a Diagnosis of TTN. Shahid Sadoughi University of Medical Sciences- Journal Management System, 2025; 7(2): 64-71. doi: 10.18502/wjpn.v7i2.20447

Evaluation of the Effect of Inhaled Salbutamol in the Treatment of Neonates with a Diagnosis of TTN

World Journal of Peri & Neonatology
Article 3, Volume 7, Issue 2, October 2025, Pages 64-71    PDF (604.8 K)
Document Type: Original Article
DOI: 10.18502/wjpn.v7i2.20447
Authors
Hasan Vahedi-Zarch1; Mohamad Hosein Lookzadeh2; Mahmood Noorishadkam2; Seyed Reza Mirjalili* 2; Mohammadreza Gholami Banadkoki1; Farimah Shamsi3
1Student Research Committee, School of Medicine, Shahid Sadoughi University of Medical Sciences, Yazd, Iran
2Mother and Newborn Health Research Center, Comprehensive Research Institute for Maternal and Child Health, Shahid Sadoughi University of Medical Sciences, Yazd, Iran
3Department of Biostatistics and Epidemiology, School of Public Health, Shahid Sadoughi University of Medical Sciences, Yazd, Iran
Abstract
Background: Transient tachypnea of the newborn (TTN), the most common cause of transient respiratory distress in neonates, occurs due to insufficient or delayed absorption of fetal alveolar fluid immediately after birth. Given the limited number of studies evaluating the effectiveness of inhaled salbutamol in TTN patients, this study aimed to assess the therapeutic effects of inhaled salbutamol and to investigate its potential side effects.
Methods: This study was a double-blind randomized clinical trial involving 100 infants with a gestational age of at least 35 weeks, who were diagnosed with TTN. The infants were randomly assigned into two groups. Within the first 6 hours after birth, the intervention group received inhaled salbutamol, while the control group received normal saline, both administered nebulization. The effectiveness of salbutamol on clinical and laboratory parameters, as well as its potential side effects, was examined in infants with TTN.                                                                     
Results: The TTN score decreased significantly in the salbutamol group at 1 and 6 hours after the intervention compared with the control group. Additionally, the time required to initiate oral feeding was longer in the group receiving salbutamol. However, regarding the length of hospitalization, duration of oxygen therapy, and other clinical parameters, no significant difference was observed between the two groups.
Conclusion: Since no significant differences were observed in major clinical outcomes between the groups, inhaled salbutamol may be considered a safe and potentially effective therapeutic option for infants with TTN.                                                                                                                                                                  
Keywords
Transient tachypnea; Respiratory distress; Salbutamol; Oxygen therapy
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