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Lookzadeh, M., Jafari Abeshoori, E., Noorishadkam, M., Mirjalili, S., Mohammadi, H., Emambakhshsani, F. (2019). Caffeine versus Aminophylline for Apnea of Prematurity: A Randomized Clinical Trial. Shahid Sadoughi University of Medical Sciences- Journal Management System, 2(2), 47-53. doi: 10.18502/wjpn.v2i2.4338
Mohamad Hosein Lookzadeh; Elaha Jafari Abeshoori; Mahmood Noorishadkam; Seyed Reza Mirjalili; Hamid Reza Mohammadi; Fatemeh Emambakhshsani. "Caffeine versus Aminophylline for Apnea of Prematurity: A Randomized Clinical Trial". Shahid Sadoughi University of Medical Sciences- Journal Management System, 2, 2, 2019, 47-53. doi: 10.18502/wjpn.v2i2.4338
Lookzadeh, M., Jafari Abeshoori, E., Noorishadkam, M., Mirjalili, S., Mohammadi, H., Emambakhshsani, F. (2019). 'Caffeine versus Aminophylline for Apnea of Prematurity: A Randomized Clinical Trial', Shahid Sadoughi University of Medical Sciences- Journal Management System, 2(2), pp. 47-53. doi: 10.18502/wjpn.v2i2.4338
Lookzadeh, M., Jafari Abeshoori, E., Noorishadkam, M., Mirjalili, S., Mohammadi, H., Emambakhshsani, F. Caffeine versus Aminophylline for Apnea of Prematurity: A Randomized Clinical Trial. Shahid Sadoughi University of Medical Sciences- Journal Management System, 2019; 2(2): 47-53. doi: 10.18502/wjpn.v2i2.4338

Caffeine versus Aminophylline for Apnea of Prematurity: A Randomized Clinical Trial

Journal of Integrated Maternal and Pediatric Care
Volume 2, Issue 2, October 2019, Pages 47-53    PDF (510.14 K)
Document Type: Original Article
DOI: 10.18502/wjpn.v2i2.4338
Authors
Mohamad Hosein Lookzadeh1, 2; Elaha Jafari Abeshoori* 2; Mahmood Noorishadkam1, 2; Seyed Reza Mirjalili1, 2; Hamid Reza Mohammadi3; Fatemeh Emambakhshsani2
1Department of Pediatrics, Shahid Sadoughi University of Medical Sciences, Yazd, Iran
2Mother and Newborn Health Research Center, Shahid Sadoughi University of Medical Sciences, Yazd, Iran
3Cardiovascular Research Center, Shahid Sadoughi University of Medical Sciences, Yazd, Iran
Abstract
 
Background: Apnea of prematurity is often found in preterm neonates with gestational age less than 34-37 weeks or birth weight (BW) less than 1000 grams. The American Academy of Pediatrics defines apnea as a respiratory halt lasting at least 20 seconds, with bradycardia or cyanosis. Methylxanthines reduce the incidence of apnea. The purpose of this study was to compare the effect of caffeine and aminophylline on the incidence of the apnea in premature infants.
Methods: This randomized clinical trial study was conducted on 80 premature neonates at Shahid Sadoughi hospital in Yazd. The first group received the initial dose of 5 mg/kg aminophylline diluted in 5% dextrose with a maintenance dose of 2 mg/kg every 8 hours, while the second group received 30 mg/kg of caffeine diluted in 5% dextrose with a 24-hour maintenance dose of 10 mg/kg.
Results: There was no significant difference infrequency of apnea between the two groups (P = 0.121). However there was a significant difference in respiratory status between the two groups so that in caffeine group, oxyhood was less necessary for neonates (P = 0.012) and using continuous positive airway pressure (CPAP) was significantly less in aminophylline group (P = 0.012).
Conclusion: Our study showed that the frequency of apnea was less in the caffeine group, but there was no significant difference between the two groups. Aminophylline treatment in comparison with caffeine can reduce the need for CPAP in neonates with apnea.
Keywords
Aminophylline; Caffeine; Apnea; Prematurity
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