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Bahrami, R., Dastgheib, S., Golestanpour, H., Akbarian, E., Emarati, A., Jafari-Nedooshan, M., Neamatzadeh, H. (2020). A Meta-Analysis for Association of ACE I/D Polymorphism with Susceptibility to Preterm Birth. Shahid Sadoughi University of Medical Sciences- Journal Management System, 3(2), 69-77. doi: 10.18502/wjpn.v3i2.6157
Reza Bahrami; Seyed Alireza Dastgheib; Hossein Golestanpour; Elahe Akbarian; Alireza Emarati; Mohammad Jafari-Nedooshan; Hossein Neamatzadeh. "A Meta-Analysis for Association of ACE I/D Polymorphism with Susceptibility to Preterm Birth". Shahid Sadoughi University of Medical Sciences- Journal Management System, 3, 2, 2020, 69-77. doi: 10.18502/wjpn.v3i2.6157
Bahrami, R., Dastgheib, S., Golestanpour, H., Akbarian, E., Emarati, A., Jafari-Nedooshan, M., Neamatzadeh, H. (2020). 'A Meta-Analysis for Association of ACE I/D Polymorphism with Susceptibility to Preterm Birth', Shahid Sadoughi University of Medical Sciences- Journal Management System, 3(2), pp. 69-77. doi: 10.18502/wjpn.v3i2.6157
Bahrami, R., Dastgheib, S., Golestanpour, H., Akbarian, E., Emarati, A., Jafari-Nedooshan, M., Neamatzadeh, H. A Meta-Analysis for Association of ACE I/D Polymorphism with Susceptibility to Preterm Birth. Shahid Sadoughi University of Medical Sciences- Journal Management System, 2020; 3(2): 69-77. doi: 10.18502/wjpn.v3i2.6157

A Meta-Analysis for Association of ACE I/D Polymorphism with Susceptibility to Preterm Birth

World Journal of Peri and Neonatology
Volume 3, Issue 2, December 2020, Pages 69-77    PDF (759.13 K)
Document Type: Original Article
DOI: 10.18502/wjpn.v3i2.6157
Authors
Reza Bahrami1; Seyed Alireza Dastgheib* 2; Hossein Golestanpour3; Elahe Akbarian4; Alireza Emarati4; Mohammad Jafari-Nedooshan5; Hossein Neamatzadeh6, 7
1Neonatal Research Center, Shiraz University of Medical Sciences, Shiraz, Iran
2Department of Medical Genetics, School of Medicine, Shiraz University of Medical Sciences, Shiraz, Iran
3Department of Genetics, Marvdasht Branch, Azad University, Marvdasht, Iran
4Children Growth Disorder Research Center, Shahid Sadoughi University of Medical Sciences, Yazd, Iran
5Shahid Rahnamoun Hospital, Shahid Sadoughi University of Medical Sciences, Yazd, Iran
6Mother and Newborn Health Research Center, Shahid Sadoughi University of Medical Sciences, Yazd, Iran
7Department of Medical Genetics, School of Medicine, Shahid Sadoughi University of Medical Sciences, Yazd, Iran
Abstract
Background: Preterm birth is one of the main contributors to newborn mortality, morbidity, and hospitalization in the first year of life globally. To date, several numbers of studies have reported that Angiotensin-Converting enzyme Insertion/Deletion polymorphism (ACE I/D) is linked with preterm birth. But those results are conflicting. Thus, we carried out this meta-analysis to summarize the existing data and evaluated the association.
Methods: All eligible studies were collected from PubMed, Scopus, SciELO, MedRxiv, SID, China National Knowledge Infrastructure (CNKI), and Chinese Biomedical Literature Database (CBLD) up to 01 March 2021. The pooled odds ratios (ORs) and 95% confidence interval (CIs) under all five genetic models were calculated using either random-effects or fixed-effects models dependent on study heterogeneity.
Results: A total of five case-control studies with 480 preterm birth cases and 702 healthy subjects were included. Pooled data showed that the ACE I/D polymorphism was significantly associated with increased risk of preterm birth under the allele model (I vs. D: OR = 1.219, 95% CI 1.023-1.453, P = 0.027), homozygote model (II vs. DD: OR = 0.662, 95% CI 1.149-2.385, P = 0.007), and recessive model (DD vs. DI+II: OR = 0.707, 95% CI 1.082-1.948, P = 0.013). Stratified analysis by ethnicity indicated that the ACE I/D polymorphism was significantly associated with preterm birth in Caucasian descendants.
Conclusion: Our pooled data revealed that ACE I/D polymorphism is associated with the risk of preterm birth. However, larger and more rigorous studies among different populations are needed to evaluate the association with preterm birth.
Keywords
Preterm Birth; Delivery; ACE; Polymorphism; Meta-Analysis
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