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Alivand, R., Abdi, F., Dehghani-Ashkezari, M., Neamatzadeh, H., Ekraminasab, S. (2020). Association of +505A>G Polymorphism at TAFI Gene with Recurrent Miscarriage in Iranian Women. Shahid Sadoughi University of Medical Sciences- Journal Management System, 3(2), 62-68. doi: 10.18502/wjpn.v3i2.6156
Razieh Alivand; Fatemeh Abdi; Mahmood Dehghani-Ashkezari; Hossein Neamatzadeh; Sedigheh Ekraminasab. "Association of +505A>G Polymorphism at TAFI Gene with Recurrent Miscarriage in Iranian Women". Shahid Sadoughi University of Medical Sciences- Journal Management System, 3, 2, 2020, 62-68. doi: 10.18502/wjpn.v3i2.6156
Alivand, R., Abdi, F., Dehghani-Ashkezari, M., Neamatzadeh, H., Ekraminasab, S. (2020). 'Association of +505A>G Polymorphism at TAFI Gene with Recurrent Miscarriage in Iranian Women', Shahid Sadoughi University of Medical Sciences- Journal Management System, 3(2), pp. 62-68. doi: 10.18502/wjpn.v3i2.6156
Alivand, R., Abdi, F., Dehghani-Ashkezari, M., Neamatzadeh, H., Ekraminasab, S. Association of +505A>G Polymorphism at TAFI Gene with Recurrent Miscarriage in Iranian Women. Shahid Sadoughi University of Medical Sciences- Journal Management System, 2020; 3(2): 62-68. doi: 10.18502/wjpn.v3i2.6156

Association of +505A>G Polymorphism at TAFI Gene with Recurrent Miscarriage in Iranian Women

World Journal of Peri and Neonatology
Volume 3, Issue 2, December 2020, Pages 62-68    PDF (421.25 K)
Document Type: Original Article
DOI: 10.18502/wjpn.v3i2.6156
Authors
Razieh Alivand1; Fatemeh Abdi2; Mahmood Dehghani-Ashkezari* 1; Hossein Neamatzadeh2, 3; Sedigheh Ekraminasab3, 4
1Biology Department, Medical Biotechnology Research Center, Ashkezar Branch, Islamic Azad University, Ashkezar, Yazd, Iran
2Department of Medical Genetics, School of Medicine, Shahid Sadoughi University of Medical Sciences, Yazd, Iran
3Mother and Newborn Health Research Center, Shahid Sadoughi University of Medical Sciences, Yazd, Iran
4Laboratory Hematology and Blood Banking Department, School of Allied Medical Sciences, Shahid Beheshti University of Medical Science, Tehran, Iran
Abstract
Background: Recurrent miscarriage (RM) is one of the major problems of public health globally. The thrombin-activatable fibrinolysis inhibitor (TAFI) gene is a plasma zymogen that regulates both fibrinolysis and inflammation. Genetic variants within TAFI gene are presumed to be associated with development of RM. This case-control study aimed to investigate the association of TAFI +505A>G polymorphism with RM in Iranian women referred to Meybod Genetic Center.
Methods: Fifty women with RM (at least 2 miscarriages) and 50 healthy women with no history of miscarriage or other fertility complications were participated in this study. The TAFI +505A>G polymorphism was genotyped by allele specific PCR (AS-PCR) assay.
Results: The mean age of cases with RM and controls was 27.25 ± 4.31 and 28.42 ± 3.22 years, respectively. The frequency of GG genotype and G allele was 0.00% in patients and controls. There was no significant difference between RM cases and controls in terms of +505A>G genotypes and alleles.
Conclusion: This study results indicated that there was no significant relationship between the TAFI +505A>G polymorphism and RM risk in Iranian women. However, further rigorous, studies with a larger sample size and different ethnicity are necessary to confirm our findings.
Keywords
Recurrent Miscarriage; Abortion; TAFI Gene; Polymorphism
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