Association between Transforming Growth Factor Alpha TaqI Polymorphism and Susceptibility to the Nonsyndromic Cleft Lip and/or Palate in an Iranian Population: A Case Control Study | ||
| Journal of Integrated Maternal and Pediatric Care | ||
| Volume 2, Issue 1, April 2019, Pages 9-14 PDF (340.25 K) | ||
| DOI: 10.18502/wjpn.v2i1.2806 | ||
| Authors | ||
| Abdolhamid Amooee1; Seyed Mohammadreza Niktabar* 1; Mohammad Javad Akbarian-Bafghi2; Majid Morovati-Sharifabad3; Mohamad Hosein Lookzadeh4; Seyed Reza Mirjalili4; Sahel Khajehnoori5, 6; Hossein Neamatzadeh5, 6 | ||
| 1Department of Surgery, Shahid Sadoughi University of Medical Sciences, Yazd, Iran | ||
| 2Department of Health Care Management, Bam University of Medical Sciences, Bam, Iran | ||
| 3Department of Basic Science, Faculty of Veterinary Medicine, Ardakan University, Ardakan, Iran | ||
| 4Department of Pediatrics, Shahid Sadoughi University of Medical Sciences, Yazd, Iran | ||
| 5Department of Medical Genetics, Shahid Sadoughi University of Medical Sciences, Yazd, Iran | ||
| 6Mother and Newborn Health Research Center, Shahid Sadoughi University of Medical Sciences, Yazd, Iran | ||
| Abstract | ||
| Background: The TGF-α TaqI C >T polymorphism is a well-characterized variant for nonsyndromic cleft lip and/or palate (NS CL/P), but it has shown inconsistent results of association with nonsyndromic CL/P across a number of studies. Thus, we have performed this case-control study to clarify the association between the TGF-α TaqI C >T polymorphism and NS CL/P risk. Methods: One-hundred ten cases with NSCL/P and 110 controls were recruited to the current study. We have genotyped the TGF-α TaqI C >T polymorphism using polymerase chain reaction-restriction fragment length polymorphism (PCR-RFLP) method. The odds ratio (OR) and 95% confidence interval (CI) were applied for strength of association TGF-α TaqI C >T polymorphism with NSCL/P. Results: The TGF-α TaqI C >T polymorphism CC, CT and TT genotypes frequencies in the NSCL/P cases were 30.9%, 57.3% and 11.8%, respectively while the corresponding frequencies in the controls were 37.3%, 52.7% and 10.0%, respectively. The frequency of C and T alleles in the case were 59.5% and 40.5%, respectively while the corresponding allelic frequencies in the controls were 63.6% and 36.4%. There was no significant difference in the genotype and allele frequency for TGF-α TaqI C >T polymorphism between cases and controls. The minor allele frequency (MAF) of TGF-α TaqI C >T polymorphism among healthy controls was 0.36. Conclusion: Our study indicates that the TGF-α TaqI C>T polymorphism was not significantly associated with increased risk of NS CL/P in the Iranian population. However, our results still need to be confirmed by further large and well-designed case-control studies. | ||
| Keywords | ||
| Nonsyndromic Cleft Lip and/or Palate; TGF-α gene; TaqI C >T; Polymorphism | ||
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