Shajari, Hamideh, Ghadyani, Mohammadamin, Hosseini-Jangjou, Seyed Hamed, Bahrami, Reza, Dastgheib, Seyed Alireza, Neamatzadeh, Hossein (2021). Association between FVL G1691A, MTHFR C677T and A1298C Polymorphisms with Risk for Retinopathy of Prematurity. Shahid Sadoughi University of Medical Sciences- Journal Management System, 4(1), 7-13. doi: 10.18502/wjpn.v4i1.7540
Hamideh Shajari; Mohammadamin Ghadyani; Seyed Hamed Hosseini-Jangjou; Reza Bahrami; Seyed Alireza Dastgheib; Hossein Neamatzadeh. "Association between FVL G1691A, MTHFR C677T and A1298C Polymorphisms with Risk for Retinopathy of Prematurity". Shahid Sadoughi University of Medical Sciences- Journal Management System, 4, 1, 2021, 7-13. doi: 10.18502/wjpn.v4i1.7540
Shajari, Hamideh, Ghadyani, Mohammadamin, Hosseini-Jangjou, Seyed Hamed, Bahrami, Reza, Dastgheib, Seyed Alireza, Neamatzadeh, Hossein (2021). 'Association between FVL G1691A, MTHFR C677T and A1298C Polymorphisms with Risk for Retinopathy of Prematurity', Shahid Sadoughi University of Medical Sciences- Journal Management System, 4(1), pp. 7-13. doi: 10.18502/wjpn.v4i1.7540
Shajari, Hamideh, Ghadyani, Mohammadamin, Hosseini-Jangjou, Seyed Hamed, Bahrami, Reza, Dastgheib, Seyed Alireza, Neamatzadeh, Hossein Association between FVL G1691A, MTHFR C677T and A1298C Polymorphisms with Risk for Retinopathy of Prematurity. Shahid Sadoughi University of Medical Sciences- Journal Management System, 2021; 4(1): 7-13. doi: 10.18502/wjpn.v4i1.7540

Association between FVL G1691A, MTHFR C677T and A1298C Polymorphisms with Risk for Retinopathy of Prematurity

Journal of Integrated Maternal and Pediatric Care
Volume 4, Issue 1, June 2021, Pages 7-13    PDF (370.99 K)
Document Type: Original Article
DOI: 10.18502/wjpn.v4i1.7540
Authors
Hamideh Shajari1; Mohammadamin Ghadyani* 2; Seyed Hamed Hosseini-Jangjou3; Reza Bahrami4; Seyed Alireza Dastgheib5; Hossein Neamatzadeh6, 7
1Department of Pediatrics, Shahid Beheshti University of Medical Sciences, Tehran, Iran
2Department of Advanced Medical Sciences and Technologies, Islamic Azad University, Science and Research Branch, Tehran, Iran
3Department of Pediatrics, Iranshahr University of Medical Sciences, Iranshahr, Iran
4Neonatal Research Center, Shiraz University of Medical Sciences, Shiraz, Iran
5Department of Medical Genetics, School of Medicine, Shiraz University of Medical Sciences, Shiraz, Iran
6Mother and Newborn Health Research Center, Shahid Sadoughi University of Medical Sciences, Yazd, Iran
7Department of Medical Genetics, School of Medicine, Shahid Sadoughi University of Medical Sciences, Yazd, Iran
Abstract
Background: Retinopathy of prematurity (ROP) is an important cause of preventable blindness in children. The aim of this study was to examine the association of the polymorphisms at Factor V Leiden (FVL) and methylene tetrahydrofolate reductase (MTHFR) gene with risk of ROP.
Methods: A total of 106 neonates with ROP and 110 healthy neonates were enrolled. The FVL G1691A and MTHFR C677T and A1298C polymorphisms were genotyped by PCR-RFLP assay.
Results: There was a significant association between FVL G1691A polymorphism and an increased risk of ROP. However, the MTHFR C677T and A1298C polymorphisms were not associated with risk of ROP.
Conclusion: FVL G1691A polymorphism may be risk factor for development of ROP in neonates. However, there was no significant association between MTHFR C677T and A1298C polymorphisms and risk of ROP. However, it is critical that larger and well-designed studies in different ethnicities are needed to confirm our conclusions.
Keywords
Retinopathy of Prematurity; Neonate; Factor V Leiden; MTHFR Gene
References
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