Association of TCF7L2 Polymorphisms with Susceptibility to Gestational Diabetes Mellitus: A Systematic Review and Meta-analysis | ||
| Journal of Integrated Maternal and Pediatric Care | ||
| Volume 4, Issue 2, December 2021, Pages 88-103 PDF (1.59 M) | ||
| Document Type: Systematic Review | ||
| DOI: 10.18502/wjpn.v4i2.8647 | ||
| Authors | ||
| Maryam Motamadinasab1, 2; Seyed Alireza Dastgheib* 3; Mohammad Golshan-Tafti4; Reza Bahrami5; Atiyeh Javaheri1; Razieh Sadat Tabatabaie1; Mahtab Ordooei6, 7; Hossein Neamatzadeh7, 8 | ||
| 1Department of Obstetrics and Gynecology, Shahid Sadoughi University of Medical Sciences, Yazd, Iran | ||
| 2Department of Obstetrics and Gynecology, Ahvaz Jundishapur University of Medical Science, Ahvaz, Iran | ||
| 3Department of Medical Genetics, School of Medicine, Shiraz University of Medical Sciences, Shiraz, Iran | ||
| 4Department of Pediatrics, Islamic Azad University of Yazd, Yazd, Iran | ||
| 5Neonatal Research Center, Shiraz University of Medical Sciences, Shiraz, Iran | ||
| 6Hematology and Oncology Research Center, Shahid Sadoughi University of Medical Sciences, Yazd, Iran | ||
| 7Mother and Newborn Health Research Center, Shahid Sadoughi University of Medical Sciences, Yazd, Iran | ||
| 8Department of Medical Genetics, School of Medicine, Shahid Sadoughi University of Medical Sciences, Yazd, Iran | ||
| Abstract | ||
| Background: Gestational diabetes mellitus (GDM) is a complex metabolic disorder of pregnancy with a strong genetic predisposition. GDM is associated with complications during pregnancy and increased risk of type 2 diabetes later in mothers and develops a vicious cycle of metabolic diseases for future generations. Evidence is accumulating that women with genetic variants at transcription factor 7-like 2 (TCF7L2) gene are more susceptible to GDM. The aim of the current meta-analysis was to assess the association of the TCF7L2 polymorphisms with GDM risk. Methods: PubMed, Web of Science, Embase, SID and CNKI databases were searched to identify relevant studies up to November 01, 2020. Using the fixed-effect or random-effect model, the pooled odds ratio and its corresponding 95% confidence interval were computed. Results: A total of 38 case-control studies including 24 studies with 6021 cases and 13289 controls on rs7903146, eight studies with 2404 cases and 2615 controls on rs12255372 and six studies with 1357 cases and 2858 controls on rs7901695 polymorphism were selected. Pooled data showed that there was a significant association between the TCF7L2 rs7903146, rs12255372 and rs7901695 polymorphisms and an increased risk of GDM in whole population. Stratified analysis showed that the TCF7L2 rs7903146 polymorphism was associated with GDM in Caucasian, mixed and Chinese women, but not in Asians. Moreover, the TCF7L2 rs12255372 polymorphism was associated with GDM in Asians and Caucasians women with GDM. Conclusion: The combined data indicated that the TCF7L2 rs7903146, rs12255372 and rs7901695 polymorphisms were associated with a significant risk of GDM in whole population, especially in Caucasian women. | ||
| Keywords | ||
| Gestational Diabetes Mellitus; Metabolic Disorder; TCF7L2; Risk; Polymorphism | ||
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