Hajialiakbari, Negin, Schwartz, David A., Javaheri, Atiyeh, Karimi-Zarchi, Mojgan, Golshan-Tafti, Mohammad, Dastgheib, Seyed Alireza, Bahrami, Reza, Zanbagh, Leila, Neamatzadeh, Hossein (2021). A Meta-Analysis for Frequency of Miscarriage in Pregnant Women with COVID-19. Shahid Sadoughi University of Medical Sciences- Journal Management System, 4(2), 104-114. doi: 10.18502/wjpn.v4i2.8648
Negin Hajialiakbari; David A. Schwartz; Atiyeh Javaheri; Mojgan Karimi-Zarchi; Mohammad Golshan-Tafti; Seyed Alireza Dastgheib; Reza Bahrami; Leila Zanbagh; Hossein Neamatzadeh. "A Meta-Analysis for Frequency of Miscarriage in Pregnant Women with COVID-19". Shahid Sadoughi University of Medical Sciences- Journal Management System, 4, 2, 2021, 104-114. doi: 10.18502/wjpn.v4i2.8648
Hajialiakbari, Negin, Schwartz, David A., Javaheri, Atiyeh, Karimi-Zarchi, Mojgan, Golshan-Tafti, Mohammad, Dastgheib, Seyed Alireza, Bahrami, Reza, Zanbagh, Leila, Neamatzadeh, Hossein (2021). 'A Meta-Analysis for Frequency of Miscarriage in Pregnant Women with COVID-19', Shahid Sadoughi University of Medical Sciences- Journal Management System, 4(2), pp. 104-114. doi: 10.18502/wjpn.v4i2.8648
Hajialiakbari, Negin, Schwartz, David A., Javaheri, Atiyeh, Karimi-Zarchi, Mojgan, Golshan-Tafti, Mohammad, Dastgheib, Seyed Alireza, Bahrami, Reza, Zanbagh, Leila, Neamatzadeh, Hossein A Meta-Analysis for Frequency of Miscarriage in Pregnant Women with COVID-19. Shahid Sadoughi University of Medical Sciences- Journal Management System, 2021; 4(2): 104-114. doi: 10.18502/wjpn.v4i2.8648

A Meta-Analysis for Frequency of Miscarriage in Pregnant Women with COVID-19

Journal of Integrated Maternal and Pediatric Care
Volume 4, Issue 2, December 2021, Pages 104-114    PDF (910.71 K)
Document Type: Systematic Review
DOI: 10.18502/wjpn.v4i2.8648
Authors
Negin Hajialiakbari1; David A. Schwartz2; Atiyeh Javaheri3; Mojgan Karimi-Zarchi4, 5; Mohammad Golshan-Tafti6; Seyed Alireza Dastgheib7; Reza Bahrami* 8; Leila Zanbagh9; Hossein Neamatzadeh10, 11
1Department of Obstetrics and Gynecology, Kermanshah University of Medical Sciences, Kermanshah, Iran
2Department of Pathology, Medical College of Georgia, Augusta, GA, USA
3Department of Obstetrics and Gynecology, Shahid Sadoughi University of Medical Sciences, Yazd, Iran
4Endometriosis Research Center, Iran University of Medical Sciences, Firoozgar Hospital, Tehran, Iran
5Department of Obstetrics and Gynecology, Iran University of Medical Sciences, Tehran, Iran
6Department of Pediatrics, Islamic Azad University of Yazd, Yazd, Iran
7Department of Medical Genetics, School of Medicine, Shiraz University of Medical Sciences, Shiraz, Iran
8Neonatal Research Center, Shiraz University of Medical Sciences, Shiraz, Iran
9Department of Obstetrics and Gynecology, Yazd Branch, Islamic Azad University, Yazd, Iran
10Mother and Newborn Health Research Center, Shahid Sadoughi University of Medical Sciences, Yazd, Iran
11Department of Medical Genetics, School of Medicine, Shahid Sadoughi University of Medical Sciences, Yazd, Iran
Abstract
Background: Most pregnant women with COVID-19 develop less severe form of the disease, with few cases of severe maternal morbidity and mortality, or perinatal deaths. This meta-analysis was conducted to evaluate the frequency of miscarriage in pregnant women affected by the SARS-COV-2 infection.
Methods: A comprehensive search was performed in online databases to identify all relevant studies published up to 5th March 2021. Case-control studies and case series reported the frequency of miscarriage in pregnant women with COVID-19 was selected.
Results: A total of 22 studies with 8591 infected pregnant women and 141 abortions were selected. The frequency of miscarriage was 3.9% (95% CI 0.023-0.063) in infected pregnant women with COVID-19. It had the highest frequency in Asian (6.3%) followed by European (2.9%), West-Asian (2.5%) and Caucasian (2.3%) infected pregnant women. Moreover, stratified analysis by country showed that the frequency of miscarriage is the highest in Chinese (11.3%) followed by Italy (11.2%), India (2.7%), Turkey (2.2%), USA (1.2%) and France (0.9%) infected pregnant women.
Conclusion: Our pooled data revealed that the frequencies of miscarriage in pregnant women with SARS-COV-2 infection were 3.9%.
Keywords
SARS-COV-2; COVID-19; Pregnancy; Abortion; Miscarriage; Frequency
References
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