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The Relationship between Obsessive-Compulsive Disorder and Irritable Bowel Syndrome: A Systematic Review and Meta-Analysis | ||
| Critical Comments in Biomedicine | ||
| Articles in Press, Accepted Manuscript, Available Online from 26 March 2022 | ||
| Document Type: Article | ||
| Authors | ||
| Omran Davarinejad1; Tahereh Mohammadi Majd2; Yahya Salimi* 3; Masoumeh Abbasi4; Maryam Shirzadi5; Ehsan Zereshki6 | ||
| 1Clinical Research Development Center, Imam Khomeini and Mohammad Kermanshahi and Farabi Hospitals, Kermanshah University of Medical Sciences, Kermanshah, Iran | ||
| 2Department of Biostatistics, School of Health, Kermanshah University of Medical Sciences, Kermanshah, Iran | ||
| 3Social Developing and Health Promotion Research Center, Health Institute, Kermanshah University of Medical Sciences, Kermanshah, Iran | ||
| 4Department of Health Information Technology, School of Paramedical, Kermanshah University of Medical Sciences, Kermanshah, Iran | ||
| 5Clinical Research Development Center Imam Khomeini and Mohammad Kermanshahi and Farabi Hospitals, Kermanshah University of Medical Sciences, Kermanshah, Iran | ||
| 6Student Research Committee, School of Public Health, Kermanshah University of Medical Sciences, Kermanshah, Iran | ||
| Abstract | ||
| Introduction: Irritable bowel syndrome (IBS) is often associated with psychiatric disorders such as obsessive-compulsive disorder (OCD). This meta-analysis was conducted to compare the rate of OCD among patients with IBS and a control group. Methods: This study was conducted using a meta-analysis approach. International databases including PubMed, Web of Science, and Scopus, as well as the Google Scholar search engine from 1985 to August 2020 were searched to find the related studies. The standardized mean difference (SMD) of OCD between the case and control groups was calculated and analyzed by a random-effects model. In addition, meta-regression and sub-group analysis were performed to identify possible causes of heterogeneity. All statistical analyses were performed through Stata 11.0. Results: A total of 5167 patients including 1451 IBS patients for case and 3716 for control group collected from 15 studies entered the analysis. Based on the results of the random effects analysis, the rate of obsessive-compulsive disorder in IBS patients in case group was higher than the control group (Pooled SMD, 0.76, I2 = 87.8%; 95% CI, 0.54-0.98; P <0.001). Egger (P = 0.083) and Begg (P = 0.09) tests did not show significant publication bias. Subgroup analysis also revealed that the type of studies and IBS diagnostic criteria were identified as factors affecting heterogeneity. Conclusion: The present meta-analysis demonstrated that the rate of obsessive-compulsive disorder in IBS patients was higher than the control group, regardless of subgroup analysis or meta-regression. Due to the significant relationship between these two disorders, psychiatrists and gastroenterologists can provide strategies and techniques for individual or group treatment of obsessive-compulsive disorder in patients with IBS based on the cognitive-behavioral therapy. | ||
| Keywords | ||
| Irritable Bowel Syndrome; Obsessive-Compulsive; OCD; IBS; Meta-Analysis | ||
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