Main Molecular Factors and Pathways in the Anti-cancer Act of Crocin | ||
| Advances in Pharmacology and Therapeutics Journal | ||
| Article 3, Volume 3, Issue 2 - Serial Number 5, Summer 2023, Pages 84-86 PDF (215.13 K) | ||
| Document Type: Letter to editor | ||
| DOI: 10.18502/aptj.v3i2.13460 | ||
| Authors | ||
| Marzieh Lotfi; Seyed Hossein Shahcheraghi* | ||
| Abstract | ||
| One of the herbal materials with several anti-inflammatory and antioxidant characteristics is crocin, an effective component derived from saffron, which can be applied to cure a range of diseases. It has been demonstrated that crocin has an important impact on controlling pathological situations such as inflammation, oxidative stress, neurodegenerative diseases, metabolic disorders, and cancer. Notch, PI3K/AKT/mTOR, and cyclic-AMP response element-connecting factor pathways may all be involved in crocin's neuroprotective properties. With its inhibitory effect on toll-like receptors, crocin also preserves the cardiovascular system. Treatment of metabolic problems may be performed by crocin's regulatory influence on the PI3K pathway, mitogen-activated protein kinases, and peroxisome proliferator-stimulated receptor pathways. This letter has investigated effective molecular factors in the anticancer act of crocin. | ||
| Keywords | ||
| Crocin; Anticancer; Molecular factors | ||
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