Daya, Ahmad, Lookzadeh, Mohamad Hosein, Noorishadkam, Mahmood, Mirjalili, Seyed Reza, Ekraminasab, Sedigheh (2023). The Effect of the Iranian Surfactant (Beraksurf) in the Treatment of Respiratory Distress Syndrome in Premature Neonates. Shahid Sadoughi University of Medical Sciences- Journal Management System, 6(1), 10-16. doi: 10.18502/wjpn.v6i1.14248
Ahmad Daya; Mohamad Hosein Lookzadeh; Mahmood Noorishadkam; Seyed Reza Mirjalili; Sedigheh Ekraminasab. "The Effect of the Iranian Surfactant (Beraksurf) in the Treatment of Respiratory Distress Syndrome in Premature Neonates". Shahid Sadoughi University of Medical Sciences- Journal Management System, 6, 1, 2023, 10-16. doi: 10.18502/wjpn.v6i1.14248
Daya, Ahmad, Lookzadeh, Mohamad Hosein, Noorishadkam, Mahmood, Mirjalili, Seyed Reza, Ekraminasab, Sedigheh (2023). 'The Effect of the Iranian Surfactant (Beraksurf) in the Treatment of Respiratory Distress Syndrome in Premature Neonates', Shahid Sadoughi University of Medical Sciences- Journal Management System, 6(1), pp. 10-16. doi: 10.18502/wjpn.v6i1.14248
Daya, Ahmad, Lookzadeh, Mohamad Hosein, Noorishadkam, Mahmood, Mirjalili, Seyed Reza, Ekraminasab, Sedigheh The Effect of the Iranian Surfactant (Beraksurf) in the Treatment of Respiratory Distress Syndrome in Premature Neonates. Shahid Sadoughi University of Medical Sciences- Journal Management System, 2023; 6(1): 10-16. doi: 10.18502/wjpn.v6i1.14248

The Effect of the Iranian Surfactant (Beraksurf) in the Treatment of Respiratory Distress Syndrome in Premature Neonates

Journal of Integrated Maternal and Pediatric Care
Article 2, Volume 6, Issue 1, December 2023, Pages 10-16    PDF (392.29 K)
Document Type: Original Article
DOI: 10.18502/wjpn.v6i1.14248
Authors
Ahmad Daya1; Mohamad Hosein Lookzadeh* 1; Mahmood Noorishadkam1; Seyed Reza Mirjalili1; Sedigheh Ekraminasab1, 2
1Mother and Newborn Health Research Center, Shahid Sadoughi Hospital, School of Medicine, Shahid Sadoughi University of Medical Sciences, Yazd, Iran
2Department of Hematology and Blood Banking, School of Allied Medical Sciences, Shahid Beheshti University of Medical Sciences, Tehran, Iran
Abstract
Background: Respiratory distress syndrome (RDS) is a type of lung development defect that is commonly seen in preterm births. Deficiency of pulmonary surfactant due to immaturity is the principal cause of RDS in premature infants. This study was conducted with the aim of Iranian surfactant (Beraksurf)’s effect in treating RDS in premature neonates.
Methods: In this study, all infants who were premature and had RDS were included in the study. Also, the infants were examined based on primary and secondary outcomes. Primary outcomes include the duration of need for nasal continuous positive airway pressure (NCPAP), number of surfactant administration, and secondary outcomes including bronchopulmonary dysplasia (BPD), pneumothorax, and pulmonary hemorrhage.
Results: A total of 162 neonates with a mean gestational age of 31.28 ± 2.58 weeks were evaluated. The 120 people (74.1%) used medicine only on the first day, 19 people on other days, and 23 people on the first and second day. Also, 141 children (87.6%) were discharged from the hospital and unfortunately, 20 children (12.4%) died. The prevalence of pneumothorax, BPD, and pulmonary hemorrhage was 1.8%, 1.2%, and 1.2% respectively. Also, 69.7% needed less than five days of mechanical ventilation and 30.2% needed more than 5 days of mechanical ventilation.
Conclusion: Considering getting better treatment results from taking Beraksurf, as well as fewer side effects and the fact that this drug is Iranian, and due to its easier access and cheaper price, we can pay more attention to the prescription of this drug.
Keywords
Premature Birth; Respiratory Distress Syndrome; Pulmonary Surfactants; Newborn; Pneumothorax; Bronchopulmonary Dysplasia
References
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