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Bahrami, R., Asadian, F., Golshan-Tafti, M. (2023). Evaluation of Immune Response to COVID-19 in Neonates. Shahid Sadoughi University of Medical Sciences- Journal Management System, 6(1), 40-48. doi: 10.18502/wjpn.v6i1.14251
Reza Bahrami; Fatemeh Asadian; Mohammad Golshan-Tafti. "Evaluation of Immune Response to COVID-19 in Neonates". Shahid Sadoughi University of Medical Sciences- Journal Management System, 6, 1, 2023, 40-48. doi: 10.18502/wjpn.v6i1.14251
Bahrami, R., Asadian, F., Golshan-Tafti, M. (2023). 'Evaluation of Immune Response to COVID-19 in Neonates', Shahid Sadoughi University of Medical Sciences- Journal Management System, 6(1), pp. 40-48. doi: 10.18502/wjpn.v6i1.14251
Bahrami, R., Asadian, F., Golshan-Tafti, M. Evaluation of Immune Response to COVID-19 in Neonates. Shahid Sadoughi University of Medical Sciences- Journal Management System, 2023; 6(1): 40-48. doi: 10.18502/wjpn.v6i1.14251

Evaluation of Immune Response to COVID-19 in Neonates

World Journal of Peri and Neonatology
Article 5, Volume 6, Issue 1, December 2023, Pages 40-48    PDF (516.99 K)
Document Type: Scientific Review
DOI: 10.18502/wjpn.v6i1.14251
Authors
Reza Bahrami1; Fatemeh Asadian* 2; Mohammad Golshan-Tafti3
1Department of Pediatrics, Neonatal Research Center, Shiraz University of Medical Sciences, Shiraz, Iran
2Department of Medical Laboratory Sciences, School of Paramedical Science, Shiraz University of Medical Sciences, Shiraz, Iran
3Department of Pediatrics, Islamic Azad University of Yazd, Yazd, Iran
Abstract
Background: During the COVID-19 epidemic, many neonates were involved, but they had fewer complications and deaths than adults. Therefore, in this review study, we investigated the immune mechanisms of neonates in response to COVID-19.
Methods: We reviewed articles that evaluated the immune system, COVID-19, or SARS-COV2 in neonates. We searched the databases of Google Scholar, PubMed, Scopus, Web of Sciences, SciELO, and CNKI databases published up to December 2022.
Results: There are different immune mechanisms in response to COVID-19 in infants, which lead to a different response to COVID-19 compared to adults. The important mechanisms include lower expression of ACE2 receptor, abundant of naive T cells, absence of cytokine storm, abundant of immunosuppressive cells, less inflammatory reactions, breastmilk secretory IgA, transfer of IgG through the placenta, and absence of chronic comorbidities. Also, in comparison with pediatrics multisystem inflammatory syndrome in children (MIS‐C) doesn’t observe in neonates.
Conclusion: The exact immune mechanisms in response to COVID-19 in infants have not yet been discovered, but knowing the exact mechanisms can be effective in future treatments, the production of effective vaccines, and other viral treatments, so there is a need for more investigations in this field.
Keywords
COVID-19; Immune System; T-cell; Neonate; Inflammation; Immunosuppressive
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