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Mirhosseini, N., Noorishadkam, M., Mohammad Amoli, M., Khosravinejad, A. (2024). Four Patients with Neonatal Diabetes Mellitus and their Outcomes: A Case Series. , 6(2), 107-112. doi: 10.18502/wjpn.v6i2.15492
Naser Ali Mirhosseini; Mahmood Noorishadkam; Mahsa Mohammad Amoli; Amir Hossein Khosravinejad. "Four Patients with Neonatal Diabetes Mellitus and their Outcomes: A Case Series". , 6, 2, 2024, 107-112. doi: 10.18502/wjpn.v6i2.15492
Mirhosseini, N., Noorishadkam, M., Mohammad Amoli, M., Khosravinejad, A. (2024). 'Four Patients with Neonatal Diabetes Mellitus and their Outcomes: A Case Series', , 6(2), pp. 107-112. doi: 10.18502/wjpn.v6i2.15492
Mirhosseini, N., Noorishadkam, M., Mohammad Amoli, M., Khosravinejad, A. Four Patients with Neonatal Diabetes Mellitus and their Outcomes: A Case Series. , 2024; 6(2): 107-112. doi: 10.18502/wjpn.v6i2.15492

Four Patients with Neonatal Diabetes Mellitus and their Outcomes: A Case Series

World Journal of Peri and Neonatology
Volume 6, Issue 2, June 2024, Pages 107-112    PDF (553.63 K)
Document Type: Case Report
DOI: 10.18502/wjpn.v6i2.15492
Authors
Naser Ali Mirhosseini1, 2, 3; Mahmood Noorishadkam3; Mahsa Mohammad Amoli4; Amir Hossein Khosravinejad* 2
1Children Growth Disorder Research Center, Shahid Sadoughi University of Medical Sciences, Yazd, Iran
2Department of Pediatrics, School of Medicine, Shahid Sadoughi University of Medical Sciences, Yazd, Iran
3Mother and Newborn Health Research Center, Shahid Sadoughi University of Medical Sciences, Yazd, Iran
4Metabolic Disorders Research Center, Endocrinology and Metabolism Mulecular-Cellular Sciences Institute, Tehran University of Medical Sciences, Tehran, Iran
Abstract
Background: Neonatal diabetes mellitus (NDM) is a severe type of glucose metabolism disorder that appears in the first months of life and mostly presents with symptoms such as dehydration, inability to gain weight, and in extreme cases, ketoacidosis and coma. Strong evidence shows the benefits of early molecular tests that investigate variability in kATP channels such as KCNJ11, ABCC8, INS gene mutations, and 6q24 abnormalities. In the presence of these genomics changes, switching from Insulin treatment toward high-dose oral sulfonylurea can enhance the course of treatment, prognosis, and quality of life.
Case Report: In this study, we report four cases of neonatal diabetes with different symptoms who were referred to Shahid Sadoughi Medical Center in Yazd, Iran.
Conclusion: The diagnosis and treatment of NDM is a good model for implementing patient-centered and personalized medicine. For all patients with diabetes diagnosed before the 6th month of their age (even the 12th month), genetic testing should be considered.
Keywords
Neonatal diabetes mellitus; Glucose metabolism disorder; Insulin; Genetic testing
References
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