Akrami, Alimohammad, Dehghani Tafti, Faezeh, Razavi-Ratki, Seyed Kazem, Mohammadi, Mohsen, Sarebanhassanabadi, Mohammadtaghi, Malekpoor, Maliheh, Ghiasi Hafezi, Najmeh, Seyed Hossaini Tezerjani, Seyed Mostafa (2024). Survival benefit of ICD implantation for primary prevention in dilated cardiomyopathy. Shahid Sadoughi University of Medical Sciences- Journal Management System, 4(1), 26-30. doi: 10.18502/cbj.v4i1.16224
Alimohammad Akrami; Faezeh Dehghani Tafti; Seyed Kazem Razavi-Ratki; Mohsen Mohammadi; Mohammadtaghi Sarebanhassanabadi; Maliheh Malekpoor; Najmeh Ghiasi Hafezi; Seyed Mostafa Seyed Hossaini Tezerjani. "Survival benefit of ICD implantation for primary prevention in dilated cardiomyopathy". Shahid Sadoughi University of Medical Sciences- Journal Management System, 4, 1, 2024, 26-30. doi: 10.18502/cbj.v4i1.16224
Akrami, Alimohammad, Dehghani Tafti, Faezeh, Razavi-Ratki, Seyed Kazem, Mohammadi, Mohsen, Sarebanhassanabadi, Mohammadtaghi, Malekpoor, Maliheh, Ghiasi Hafezi, Najmeh, Seyed Hossaini Tezerjani, Seyed Mostafa (2024). 'Survival benefit of ICD implantation for primary prevention in dilated cardiomyopathy', Shahid Sadoughi University of Medical Sciences- Journal Management System, 4(1), pp. 26-30. doi: 10.18502/cbj.v4i1.16224
Akrami, Alimohammad, Dehghani Tafti, Faezeh, Razavi-Ratki, Seyed Kazem, Mohammadi, Mohsen, Sarebanhassanabadi, Mohammadtaghi, Malekpoor, Maliheh, Ghiasi Hafezi, Najmeh, Seyed Hossaini Tezerjani, Seyed Mostafa Survival benefit of ICD implantation for primary prevention in dilated cardiomyopathy. Shahid Sadoughi University of Medical Sciences- Journal Management System, 2024; 4(1): 26-30. doi: 10.18502/cbj.v4i1.16224

Survival benefit of ICD implantation for primary prevention in dilated cardiomyopathy

Cardiovascular Biomedicine
Volume 4, Issue 1, August 2024, Pages 26-30    PDF (524.29 K)
Document Type: Original articles
DOI: 10.18502/cbj.v4i1.16224
Authors
Alimohammad Akrami1; Faezeh Dehghani Tafti1; Seyed Kazem Razavi-Ratki2; Mohsen Mohammadi1; Mohammadtaghi Sarebanhassanabadi1; Maliheh Malekpoor1; Najmeh Ghiasi Hafezi1; Seyed Mostafa Seyed Hossaini Tezerjani* 1
1Yazd Cardiovascular Research Center, Non-communicable Diseases Research Institute, Shahid Sadoughi University of Medical Sciences, Yazd, Iran
2Department of Radiology, Faculty of Medicine, Shahid Sadoughi University of Medical Sciences, Yazd, Iran
Abstract
Objectives: Dilated cardiomyopathy (DCM) represents a significant cause of heart failure unrelated to ischemic heart disease, posing a high risk of sudden cardiac death (SCD) due to low left ventricular ejection fraction (LVEF). This study evaluates the survival benefits of implantable cardiac defibrillators (ICDs) for primary prevention in DCM patients.

Methods: We enrolled 52 symptomatic non-ischemic cardiomyopathy patients (LVEF ≤ 35%, NYHA class II-III) eligible for ICD implantation in Afshar Hospital, Yazd, Iran, from 2014 to 2015. Exclusion criteria included those with ischemic indications or requiring cardiac resynchronization therapy. We divided patients into ICD recipients and those on a waiting list, collected the baseline data (age, functional class, LVEF), then followed up with patients to assess mortality rates.

Results: Among 45 patients, 64.5% received ICDs while 35.5% were on the waiting list. The mean age was 57±13 years, predominantly male (67.3%). The ICD group had a significantly lower mortality rate (17.3%) than the waiting list group (42.7%, p = 0.54). Although age and functional class did not significantly predict outcomes, lower LVEF was a crucial factor for long-term survival. Despite some studies suggesting no survival benefit in non-ischemic heart failure, our findings highlight the efficacy of ICDs in reducing mortality among DCM patients.
 
Conclusions: ICD implantation in DCM patients substantially reduces all-cause mortality compared to those awaiting the procedure, underscoring the importance of timely ICD deployment for primary prevention in this population.
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