Therapeutic Potential of Exosomes in Wound Healing with A Focus on Fibroblast-Derived Exosomes: A Mini Review | ||
| Regenerative Biomedicine | ||
| Volume 1, Issue 1, Summer 2024, Pages 23-31 PDF (1.02 M) | ||
| Document Type: Mini-Review | ||
| DOI: 10.22034/jrb.2024.114 | ||
| Authors | ||
| Niloofar Shokrollah1; Behrouz Aflatoonian2, 3, 4; Amirhossein Ahmadieh-Yazdi* 2 | ||
| 1Al-Zahra Educational and Remedial Center, Guilan University of Medical Sciences, Rasht, Iran | ||
| 2Stem Cell Biology Research Center, Yazd Reproductive Sciences Institute, Shahid Sadoughi University of Medical Sciences, Yazd, Iran | ||
| 3Research and Clinical Center for Infertility, Yazd Reproductive Sciences Institute, Shahid Sadoughi University of Medical Sciences, Yazd, Iran | ||
| 4Department of Reproductive Biology, School of Medicine, Shahid Sadoughi University of Medical Sciences, Yazd, Iran | ||
| Abstract | ||
| Impaired wound healing poses a significant challenge worldwide, impacting patients' quality of life and potentially leading to disability or even mortality. Despite the great progress that has been achieved, it remains a worldwide challenge to develop effective therapeutic treatments for diabetic wounds. Exosomes, have emerged as promising therapeutic tools in wound healing due to their ability to transfer bioactive molecules, including growth factors and cytokines, to target cells. Growth factors, such as platelet-derived growth factor (PDGF), transforming growth factor-beta (TGF-β), epidermal growth factor (EGF), and vascular endothelial growth factor (VEGF), play pivotal roles in regulating cellular responses, promoting tissue regeneration, and modulating key signaling pathways. The interplay between growth factors and signaling pathways, including MAPK, PI3K/Akt, and NF-κB, is an important step in wound healing process. In this mini-review we aim to summarize the progress of research on the use of various exosomes derived from different cell types, with a focus on fibroblast-derived exosomes in promoting wound healing. | ||
| Keywords | ||
| Wound healing; Exosomes; Fibroblasts; Growth factors; Signaling pathways | ||
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