Exosomes, a promising future for endometriosis | ||
| Regenerative Biomedicine | ||
| Volume 1, Issue 1, Summer 2024, Pages 32-35 PDF (909.23 K) | ||
| Document Type: Mini-Review | ||
| DOI: 10.22034/jrb.2024.115 | ||
| Authors | ||
| Elham Afkhami1; Mansoureh Movahedin* 2; Morteza Anvari3; Ehsan Farashahi Yazd4; Behrouz Aflatoonian5, 6, 7 | ||
| 1Department of anatomical sciences, faculty of medical sciences, Tarbiat modares university, Tehran, Iran | ||
| 2Anatomical Sciences Department., Medical Sciences Faculty, Tarbiat Modares University | ||
| 3Biology and Anatomical Sciences Department, Faculty of Medicine, Shahid Sadoughi of Medical Sciences, Yazd, Iran. | ||
| 4Stem Cell Biology Research Center, Yazd Reproductive Sciences Institude, Shahid Sadoughi of Medical Sciences, Yazd, Iran. | ||
| 5Stem Cell Biology Research Center, Yazd Reproductive Sciences Institute, Shahid Sadoughi University of Medical Sciences, Yazd, Iran. | ||
| 6Research and Clinical Center for Infertility, Yazd Reproductive Sciences Institute, Shahid Sadoughi University of Medical Sciences, Yazd, Iran. | ||
| 7Department of Reproductive Biology, School of Medicine, Shahid Sadoughi University of Medical Sciences, Yazd, Iran | ||
| Abstract | ||
| Endometriosis is characterized as the development of endometrial organs and stromal cells in a heterotopic area with immune dysregulation. Considering endometriosis is a chronic progressive disease primarily affecting young reproductive ages, early interventions to prevent disease progression is mandatory. Medical treatment may be effective to alleviate the symptoms, but recurrence after the cessation of medicine is frequent. In addition, there is a potential for decrease endometrial receptivity, an increase in free radicals, excessive production of prostaglandins, estrogen, as well as an imbalance in the level of cytokines, interleukins and various growth factors in this disease. Exosomes (Exos) are extracellular nanovesicles that are released from almost all cell, so Exos are one of the strategies for cellular cross‐talk. Recent studies have shown that during implantation, Exos can participate in the complex dialogue between the embryo and maternal tissues. Here, we review how endometriosis develops as a heterogeneous disease, and introduce the Exos and its potential as a new strategy in improving symptoms and fertility in these patients. | ||
| Keywords | ||
| Endometriosis; Exosomes; stem cell; Herbal products; Endometriosis animal model | ||
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