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Stem cell-based approaches for islet replacement in diabetes | ||
| Regenerative Biomedicine | ||
| Volume 1, Issue 1, September 2024, Pages 36-43 PDF (1.03 M) | ||
| Document Type: Mini-Review | ||
| DOI: 10.22034/jrb.2024.116 | ||
| Authors | ||
| Zahra Ghezel-Ayagh1, 2; Yaser Tahamtani1, 2; Babak Arjmand3; Hamid Reza Aghayan* 4 | ||
| 1Department of Basic and Population Based Studies in NCD, Reproductive Epidemiology Research Center, Rayan Institute, ACECR, Tehran, Iran | ||
| 2Department of Stem Cells and Developmental Biology, Cell Science Research Center, Royan Institute | ||
| 3Cell Therapy and Regenerative Medicine Research Center, Endocrinology and Metabolism Molecular-Cellular Sciences Institute, Tehran University of Medical Sciences, Tehran, Iran | ||
| 4Cell Therapy and Regenerative Medicine Research Center, Endocrinology and Metabolism Molecular-Cellular Sciences Institute, Tehran University of Medical Sciences, Tehran, Iran | ||
| Abstract | ||
| Diabetes is a complex and multifactorial metabolic disease characterized by the autoimmune destruction of pancreatic beta cells or a combination of peripheral insulin resistance and impaired insulin secretion. Current therapeutic approaches are not curative and have their complications. Recently, stem cell-based therapies have emerged as a promising approach with the potential to restore normoglycemia and beta cell function, reverse diabetes, achieve long-term glycemic control, and prevent complications. Various stem cell sources are being investigated to find a potential solution for manufacturing unlimited transplantable insulin-secreting cells. Significant progress has been made in preclinical studies and the generation of islet-like endocrine clusters or organoids. However, the clinical translation of these cell therapies is still in the early stages. New strategies such as gene editing and tissue engineering may improve the safety and efficacy of stem cell-derived beta or progenitor cell transplantation. This review discusses the current state of islet transplantation, different cell-based therapies, and their potential for clinical translation, with a major focus on pancreatic organoids and associated technologies. | ||
| Keywords | ||
| Cell transplantation; Diabetes mellitus; Insulin-secreting cells; Pancreatic islets; Regenerative medicine | ||
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