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| Number of Articles | 355 |
| Article View | 89,101 |
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Releasing Scaffold Can Improve Spermatogenesis | ||
| Regenerative Biomedicine | ||
| Volume 1, Issue 2, March 2025, Pages 73-77 PDF (894.82 K) | ||
| Document Type: Mini-Review | ||
| DOI: 10.22034/jrb.2025.408 | ||
| Authors | ||
| Alireza Anvari; Mansoureh Movahedin* | ||
| Department of Anatomical Sciences, Faculty of Medical Sciences, Tarbiat Modares University, Tehran, Iran | ||
| Abstract | ||
| Testicular tissue and cell transplantation have been suggested as a feasible therapeutic alternative for patients whose testicular tissue was cryopreserved before beginning gonadotoxic treatments. There have been no studies that show sperm production following the transplantation of human immature testicular tissue or spermatogonial stem cells. The main obstacles to human immature testicular tissue transplantation include the maintenance of early spermatogonial populations, hypoxia and reperfusion damage, and insufficient or delayed testicular graft neovascularization. The design and development of bioengineered scaffolding that can enhance ITT grafting in several animals and support testicular cells appears to be a potential strategy for maintaining human fertility. Original and review papers were gathered by searching the PubMed and Google Scholar databases. The search terms used were 'drug delivery', 'immature testicular tissue', 'in vivo spermatogenesis', 'scaffold', 'transplantation', and a combination of words using the AND and OR functions, as well as their corresponding equivalents in Mesh. This paper summarizes the advancements achieved in animal models of fertility restoration through the release of scaffolds. | ||
| Keywords | ||
| Drug delivery; Scaffold; Spermatogonial Stem Cells; Tissue engineering; Transplantation | ||
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Statistics Article View: 63 PDF Download: 45 |
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