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Therapeutic Potential of Amniotic Fluid and Amniotic Fluid-Derived Stem Cells in Regenerative Medicine | ||
Regenerative Biomedicine | ||
Volume 1, Issue 2, March 2025, Pages 85-105 PDF (1008.26 K) | ||
Document Type: Review Article | ||
DOI: 10.22034/jrb.2025.410 | ||
Authors | ||
Seyed Mehdi Hoseini1, 2; Faezeh Sadat Azad3; Elham Zare4, 5; Fateme Montazeri* 4 | ||
1Biotechnology Research Center, Yazd Reproductive Sciences Institute, Shahid Sadoughi University of Medical Sciences and Health Services, Yazd, Iran | ||
2Hematology and Oncology Research Center, Non-communicable Diseases Research Institute, Shahid Sadoughi University of Medical Sciences, Yazd, Iran | ||
33) Abortion Research Center, Yazd Reproductive Sciences Institute, Shahid Sadoughi University of Medical Sciences and Health Services, Yazd, Iran | ||
4Abortion Research Center, Yazd Reproductive Sciences Institute, Shahid Sadoughi University of Medical Sciences and Health Services, Yazd, Iran | ||
5Medical Genetics and Molecular Medicine Department, School of Medicine, Mashhad University of Medical Sciences, Mashhad, Iran | ||
Abstract | ||
Amniotic fluid (AF) serves as a protective medium for the developing fetus and is a rich source of biologically active components, including fetal stem cells and extracellular vesicles (EVs). Notably, mesenchymal stem cells (MSCs) and human amniotic epithelial cells (hAECs) in AF possess pluripotent-like characteristics, contributing to the development of therapeutic strategies. This review aims to explore the therapeutic potential of AF-derived stem cells (AFSCs) in regenerative medicine and immunotherapy. The review consolidates findings on the Mesenchymal Stem Cells (MSCs) and human amniotic epithelial cells (hAECs) stand out for their pluripotent-like characteristics, with hAECs originating from epiblast-derived stem cells. AF-MSCs offer several advantages over adult MSCs, addressing ethical concerns and showcasing therapeutic potential. The distinctive biological attributes of AF, including its components and derived cells, make it a promising candidate for therapeutic applications in regenerative medicine and immunotherapy strategies. Further research is warranted to elucidate specific clinical applications and mechanisms underlying its beneficial properties. | ||
Keywords | ||
Amniotic Fluid Mesenchymal Stem Cells; Cardiovascular diseases; Infertility; Neurodegenerative disease; Regenerative Medicine; Wound healing | ||
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