Hoseini, Seyed Mehdi, Azad, Faezeh Sadat, Zare, Elham, Montazeri, Fateme (2025). Therapeutic Potential of Amniotic Fluid and Amniotic Fluid-Derived Stem Cells in Regenerative Medicine. Shahid Sadoughi University of Medical Sciences- Journal Management System, 1(2), 85-105. doi: 10.22034/jrb.2025.410
Seyed Mehdi Hoseini; Faezeh Sadat Azad; Elham Zare; Fateme Montazeri. "Therapeutic Potential of Amniotic Fluid and Amniotic Fluid-Derived Stem Cells in Regenerative Medicine". Shahid Sadoughi University of Medical Sciences- Journal Management System, 1, 2, 2025, 85-105. doi: 10.22034/jrb.2025.410
Hoseini, Seyed Mehdi, Azad, Faezeh Sadat, Zare, Elham, Montazeri, Fateme (2025). 'Therapeutic Potential of Amniotic Fluid and Amniotic Fluid-Derived Stem Cells in Regenerative Medicine', Shahid Sadoughi University of Medical Sciences- Journal Management System, 1(2), pp. 85-105. doi: 10.22034/jrb.2025.410
Hoseini, Seyed Mehdi, Azad, Faezeh Sadat, Zare, Elham, Montazeri, Fateme Therapeutic Potential of Amniotic Fluid and Amniotic Fluid-Derived Stem Cells in Regenerative Medicine. Shahid Sadoughi University of Medical Sciences- Journal Management System, 2025; 1(2): 85-105. doi: 10.22034/jrb.2025.410

Therapeutic Potential of Amniotic Fluid and Amniotic Fluid-Derived Stem Cells in Regenerative Medicine

Regenerative Biomedicine
Volume 1, Issue 2, Winter 2025, Pages 85-105    PDF (1008.26 K)
Document Type: Review Article
DOI: 10.22034/jrb.2025.410
Authors
Seyed Mehdi Hoseini1, 2; Faezeh Sadat Azad3; Elham Zare4, 5; Fateme Montazeri* 4
1Biotechnology Research Center, Yazd Reproductive Sciences Institute, Shahid Sadoughi University of Medical Sciences and Health Services, Yazd, Iran
2Hematology and Oncology Research Center, Non-communicable Diseases Research Institute, Shahid Sadoughi University of Medical Sciences, Yazd, Iran
33) Abortion Research Center, Yazd Reproductive Sciences Institute, Shahid Sadoughi University of Medical Sciences and Health Services, Yazd, Iran
4Abortion Research Center, Yazd Reproductive Sciences Institute, Shahid Sadoughi University of Medical Sciences and Health Services, Yazd, Iran
5Medical Genetics and Molecular Medicine Department, School of Medicine, Mashhad University of Medical Sciences, Mashhad, Iran
Abstract
Amniotic fluid (AF) serves as a protective medium for the developing fetus and is a rich source of biologically active components, including fetal stem cells and extracellular vesicles (EVs). Notably, mesenchymal stem cells (MSCs) and human amniotic epithelial cells (hAECs) in AF possess pluripotent-like characteristics, contributing to the development of therapeutic strategies.
This review aims to explore the therapeutic potential of AF-derived stem cells (AFSCs) in regenerative medicine and immunotherapy.
The review consolidates findings on the Mesenchymal Stem Cells (MSCs) and human amniotic epithelial cells (hAECs) stand out for their pluripotent-like characteristics, with hAECs originating from epiblast-derived stem cells. AF-MSCs offer several advantages over adult MSCs, addressing ethical concerns and showcasing therapeutic potential.
The distinctive biological attributes of AF, including its components and derived cells, make it a promising candidate for therapeutic applications in regenerative medicine and immunotherapy strategies. Further research is warranted to elucidate specific clinical applications and mechanisms underlying its beneficial properties.
Keywords
Amniotic Fluid Mesenchymal Stem Cells; Cardiovascular diseases; Infertility; Neurodegenerative disease; Regenerative Medicine; Wound healing
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