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Jouei, Z., Akyash, F., Aflatoonian, B. (2026). Integrative Perspectives on In Vitro Neurogenesis; From Fundamental Mechanisms to Clinical Potential. Shahid Sadoughi University of Medical Sciences- Journal Management System, 2(1), 72-81. doi: 10.22034/jrb.2026.07.V2I1A5
Zahra Jouei; Fatemeh Akyash; Behrouz Aflatoonian. "Integrative Perspectives on In Vitro Neurogenesis; From Fundamental Mechanisms to Clinical Potential". Shahid Sadoughi University of Medical Sciences- Journal Management System, 2, 1, 2026, 72-81. doi: 10.22034/jrb.2026.07.V2I1A5
Jouei, Z., Akyash, F., Aflatoonian, B. (2026). 'Integrative Perspectives on In Vitro Neurogenesis; From Fundamental Mechanisms to Clinical Potential', Shahid Sadoughi University of Medical Sciences- Journal Management System, 2(1), pp. 72-81. doi: 10.22034/jrb.2026.07.V2I1A5
Jouei, Z., Akyash, F., Aflatoonian, B. Integrative Perspectives on In Vitro Neurogenesis; From Fundamental Mechanisms to Clinical Potential. Shahid Sadoughi University of Medical Sciences- Journal Management System, 2026; 2(1): 72-81. doi: 10.22034/jrb.2026.07.V2I1A5

Integrative Perspectives on In Vitro Neurogenesis; From Fundamental Mechanisms to Clinical Potential

Regenerative Biomedicine
Volume 2, Issue 1, July 2026, Pages 72-81    PDF (775.13 K)
Document Type: Mini-Review
DOI: 10.22034/jrb.2026.07.V2I1A5
Authors
Zahra Jouei1; Fatemeh Akyash1; Behrouz Aflatoonian* 1, 2, 3
1Stem Cell Biology Research Center, Yazd Reproductive Sciences Institute, Shahid Sadoughi University of Medical Sciences, Yazd, Iran.
2Research and Clinical Center for Infertility, Yazd Reproductive Sciences Institute, Shahid Sadoughi University of Medical Sciences, Yazd, Iran.
3Department of Reproductive Biology, School of Medicine, Shahid Sadoughi University of Medical Sciences, Yazd, Iran.
Abstract
In vitro neurogenesis, defined as the differentiation of stem cells into functional neurons under controlled laboratory conditions, represents a pivotal tool in contemporary neuroscience research and regenerative medicine. This approach enables precise modeling of neurodevelopmental processes and neurodegenerative disorders, while also supporting the exploration of novel therapeutic strategies. Stem cell–based platforms, including embryonic stem cells (ESCs), induced pluripotent stem cells (iPSCs), and neural stem cells (NSCs), provide versatile and well-characterized sources for generating diverse neuronal lineages. Experimental in vitro models such as neuronal rosettes and neurospheres offer valuable insights into early neural commitment, spatial organization, and lineage specification during neural differentiation. Furthermore, recent advances have highlighted stem cell–derived exosome therapy as a promising cell-free approach for central nervous system (CNS) regeneration. Collectively, this review summarizes major cellular sources, key molecular markers, differentiation mechanisms, and translational applications of in vitro neurogenesis, while also addressing current limitations and outlining future directions in this rapidly evolving field.
Keywords
Embryonic stem cells (ESCs); Exosome therapy; In vitro neurogenesis; Induced pluripotent stem cells (iPSCs); Neural stem cells (NSCs); Progenitors
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