Fardid, Zoheir, Mirjalili, Seyed Reza, Noorishadkam, Mahmood, Vakili, Mahmood, Saeida-Ardekani, Maryam, Lookzadeh, Mohamad Hosein (2026). A Comparison between the Two Surfactants, Beracsurf and Curosurf, in the Treatment of Respiratory Distress Syndrome (RDS) in Premature Infants. Shahid Sadoughi University of Medical Sciences- Journal Management System, 8(1), 59-66. doi: 10.18502/wjpn.v8i1.21585
Zoheir Fardid; Seyed Reza Mirjalili; Mahmood Noorishadkam; Mahmood Vakili; Maryam Saeida-Ardekani; Mohamad Hosein Lookzadeh. "A Comparison between the Two Surfactants, Beracsurf and Curosurf, in the Treatment of Respiratory Distress Syndrome (RDS) in Premature Infants". Shahid Sadoughi University of Medical Sciences- Journal Management System, 8, 1, 2026, 59-66. doi: 10.18502/wjpn.v8i1.21585
Fardid, Zoheir, Mirjalili, Seyed Reza, Noorishadkam, Mahmood, Vakili, Mahmood, Saeida-Ardekani, Maryam, Lookzadeh, Mohamad Hosein (2026). 'A Comparison between the Two Surfactants, Beracsurf and Curosurf, in the Treatment of Respiratory Distress Syndrome (RDS) in Premature Infants', Shahid Sadoughi University of Medical Sciences- Journal Management System, 8(1), pp. 59-66. doi: 10.18502/wjpn.v8i1.21585
Fardid, Zoheir, Mirjalili, Seyed Reza, Noorishadkam, Mahmood, Vakili, Mahmood, Saeida-Ardekani, Maryam, Lookzadeh, Mohamad Hosein A Comparison between the Two Surfactants, Beracsurf and Curosurf, in the Treatment of Respiratory Distress Syndrome (RDS) in Premature Infants. Shahid Sadoughi University of Medical Sciences- Journal Management System, 2026; 8(1): 59-66. doi: 10.18502/wjpn.v8i1.21585

A Comparison between the Two Surfactants, Beracsurf and Curosurf, in the Treatment of Respiratory Distress Syndrome (RDS) in Premature Infants

Journal of Integrated Maternal and Pediatric Care
Volume 8, Issue 1, May 2026, Pages 59-66    PDF (604.92 K)
Document Type: Original Article
DOI: 10.18502/wjpn.v8i1.21585
Authors
Zoheir Fardid1; Seyed Reza Mirjalili1; Mahmood Noorishadkam1; Mahmood Vakili2; Maryam Saeida-Ardekani1; Mohamad Hosein Lookzadeh* 1
1Mother and Newborn Health Research Center, Comprehensive Research Institute for Maternal and Child Health, Shahid Sadoughi University of Medical Sciences, Yazd, Iran
2Department of Community and Preventive Medicine, Health Monitoring Research Center, School of Medicine, Shahid Sadoughi University of Medical Sciences, Yazd, Iran
Abstract
Background: Respiratory distress syndrome (RDS) in premature infants results from surfactant deficiency. Given the high cost and limited availability of Curosurf, we compared its outcomes with the Iranian surfactant Beracsurf. Methods: This descriptive cross-sectional study included premature infants (≤34 weeks) with RDS who met surfactant criteria. We assessed hospitalization duration, mechanical ventilation time, delivery mode, CPAP duration, Apgar score, gestational age, and clinical outcomes (discharge/mortality). Complications (pneumothorax, pulmonary/intraventricular hemorrhage, BPD, ROP, NEC), surfactant redosing frequency, and time to FiO₂<40% were compared between groups. Results: A total of 80 infants were divided into two equal groups (40 each). Baseline demographics were similar (P>0.05). Beracsurf recipients required significantly longer mechanical ventilation (3.25 vs. 2.22 days, P=0.01) and CPAP (3.05 vs. 2.41 days, P=0.04) than Curosurf recipients. No significant differences were observed in other complications, hospitalization duration, or mortality.                                                                                                                    Conclusion: Curosurf provided significantly shorter durations of respiratory support compared to Beracsurf. Other outcomes and complication rates were comparable. Further large-scale studies are warranted to guide clinical and economic decisions.
Keywords
Respiratory Distress Syndrome, Newborn; Infant, Premature; Pulmonary Surfactants; Beractant; Poractant Alfa; Treatment Outcome
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